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Drug sustained-release implant agent and implanting device thereof

A drug and sustained-release technology, applied in the field of biomedicine, can solve the problems of uncontrollable release concentration, short effective action time, poor stability, etc., achieve significant technical advantages and scientific research value, simple and easy production and use methods, production process uncomplicated effects

Pending Publication Date: 2018-03-06
INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
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Problems solved by technology

However, due to the poor stability of oral or injected hormones in animals, the short effective time of action, and the uncontrollable release concentration, it is difficult to fully explore its role in the life process in research
In addition, in the past, due to the limitations of the implantation method, the wounds of the animals were too large during the implantation, which caused infection in mild cases and death in severe cases, resulting in huge economic losses.
[0004] In order to solve the above problems, improve the stability and long-term release of estrogen after implantation in animals, and the scientific nature of the implantation method, it is urgent to develop a slow-release agent and implantation agent that can be used for subcutaneous estrogen implantation. Implantation device, the greatest possible reduction in instability and economic losses in the process of estrogen implantation

Method used

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  • Drug sustained-release implant agent and implanting device thereof
  • Drug sustained-release implant agent and implanting device thereof
  • Drug sustained-release implant agent and implanting device thereof

Examples

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Embodiment 1

[0032] Embodiment 1 Sheep subcutaneous estrogen sustained-release implant and implant device

[0033] Taking sheep estrogen slow-release implantation as an example, refer to figure 1 and figure 2 , are described as follows in conjunction with the examples:

[0034] 1. The subcutaneous estrogen slow-release implant is composed of 17-β estradiol, laboratory grade silicone tube and medical room temperature curing adhesive. Hormone slow release rate.

[0035] 2. If figure 1 As shown in A, the silicone tube used in this example has an inner diameter of 3.5 mm and an outer diameter of 5.5 mm. First, the silicone tube is cut to 2 cm, and one port is sealed with a medical adhesive (type A transparent medical silicone), and the adhesive is solidified. Then put estrogen into the tube, the amount of estrogen in the silicone tube is 2.09±0.18mg / cm 3 , and then close another port to complete the production of estrogen implant ( figure 2 , A-C).

[0036] 3. figure 1 B is a schemat...

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Abstract

The invention discloses a drug sustained-release implant agent and an implanting device thereof. The drug sustained-release implant agent is in the form of a capsule and comprises a drug, a laboratory-grade silicone tube and a medical curing adhesive. The drug is put in the silicone tube, openings of the two ends of the silicone tube are sealed with the curing adhesive, and the drug is controlledto release by the surface micro-aperture of the silicone tube. The implanting device includes a hollow sleeve tube and a drug pushing needle core, and is used for implanting the drug sustained-releaseimplant in an animal body or subcutaneously. The drug sustained-release implant agent has the advantages of long sustained release period, stable release, and the like. The implanting device has theadvantages of simple and practical manufacturing and using methods, and has significant technical advantages and scientific value.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a drug sustained-release implant and an implant device. Background technique [0002] Estrogen is a steroid hormone that is mainly secreted by the ovaries. In mammals, estrogen mainly promotes and maintains the development of secondary sexual characteristics before puberty; after sexual maturity, estrogen mainly regulates the physiological activities of female animal hypothalamus, pituitary, ovary, placenta and reproductive tract, etc. It has a huge impact on the reproductive activities of animals. [0003] At present, in the field of life science research, methods such as estrogen implantation are widely used to study its effect on animal reproductive physiological activities. However, due to the poor stability of oral or injected hormones in animals, the short effective time of action, and the uncontrollable release concentration, it is difficult to fully explore its role...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/34A61K31/565A61D7/00
CPCA61K47/34A61D7/00A61K9/0024A61K31/565
Inventor 刘秋月储明星贺小云张效生张金龙狄冉王翔宇胡文萍
Owner INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
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