Uniform-sized konjak gulcomannan microspheres and preparation method thereof

A technology of konjac glucomannan and average particle size, which is applied in the field of small particle size konjac glucomannan microspheres and its preparation, and can solve problems such as difficulty in droplet shedding, wide particle size distribution, and increased viscosity

Active Publication Date: 2013-07-10
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the case of ensuring the same cross-linking effect, another way to improve the gel strength is to increase the content of konjac glucomannan in the gel microspheres, but as the concentration of glucomannan increases, the viscosity will also increase accordingly increase
At this time, it is difficult to prepare konjac glucomannan microspheres with small particle size by the traditional mechanical dispersion method and the existing direct membrane emulsification method.
Although the mechanical dispersion method can reduce the particle size by increasing the stirring speed, the particle size distribution obtained by the dispersion method is very wide, and there are

Method used

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  • Uniform-sized konjak gulcomannan microspheres and preparation method thereof
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  • Uniform-sized konjak gulcomannan microspheres and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0069] Embodiment 1: the preparation of konjac glucomannan aqueous solution (such as figure 2 )

[0070] In a 500ml reactor, mix 20ml of 0.5M HCl and 120g of deionized water evenly, pour 20.0g of konjac glucomannan into the mixture, stir evenly, and swell for 5 minutes to form jelly. Cover the reactor with parafilm or a watch glass, put it in an autoclave, and degrade it at 115°C for 30 minutes. After the degradation is complete, take out the reactor and place it at room temperature. Add 40g of 40% NaOH solution, stir to dissolve the slurry, and filter impurities to obtain a clear aqueous solution of 10% konjac glucomannan. The same method can prepare konjac glucomannan aqueous solution with solid content of 0.1%, 4%, 15%, 20%, 40% and so on for future use.

Embodiment 2

[0072] Put a membrane with a pore size of 9.2 μm in a lipophilic substance for infiltration, add 37.5g of oil-soluble emulsifier Span 80 to 750g of a mixture of liquid paraffin and petroleum ether (mass ratio 11:1), and stir until completely dissolved And heated to 60°C as an oil phase. Quickly mix 100g of the water phase (the concentration of konjac glucomannan is 5%) with the oil phase and emulsify at 5000rpm for 30 seconds with homogeneous emulsification. kgf / cm 2 Quickly pass through a microporous membrane with uniform pore size under pressure to obtain a W / O emulsion with relatively uniform particle size, and use the obtained emulsion as a primary emulsion at 0.5kgf / cm 2 The pressure passes through the microporous membrane again and repeats the emulsification three times; after the emulsification is completed, slowly add 50 g of the cross-linking agent epichlorohydrin into the emulsion for about 0.5 hours. After the dropwise addition, the cross-linking reaction was carr...

Embodiment 3

[0074] Place a membrane with a pore size of 10.2 μm in a lipophilic substance for infiltration, add 8015 g of oil-soluble emulsifier Span to 500 g of a mixture of liquid paraffin and petroleum ether (mass ratio 7:5), stir until completely dissolved and heat to 50°C as the oil phase. Quickly mix 100g of the water phase (the concentration of konjac glucomannan is 12%) with the oil phase and emulsify at 5000rpm for 30 seconds with homogeneous emulsification. kgf / cm 2 Rapidly pass through a microporous membrane with uniform pore size under pressure to obtain a W / O emulsion with relatively uniform particle size, and use the obtained emulsion as a primary emulsion at 0.7kgf / cm 2 The pressure passes through the microporous membrane again and repeats the emulsification three times; after the emulsification is completed, slowly add 50 g of the cross-linking agent epichlorohydrin into the emulsion for about 0.5 hours. After the dropwise addition was completed, the crosslinking reactio...

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Abstract

The invention relates to uniform-sized konjak gulcomannan microspheres. The average particle size of the microspheres is less than 10 mu m; the content of the konjak gulcomannan in the microspheres is greater than 20% (w/w); the particle size is uniform; and the particle size distribution coefficient Span value is less than 0.9. The invention further provides a preparation method of the microspheres. According to the invention, the problems that the konjak gulcomannan microspheres of which the particle size is less than 10 mu m are hard to prepare by using the conventional method and the prepared microspheres are not uniform in particle size are solved.

Description

technical field [0001] The invention relates to the field of biochemical separation and drug carrier of bioengineering, in particular, the invention relates to konjac glucomannan microspheres with uniform size and small particle size and a preparation method thereof. Background technique [0002] Konjac glucomannan (KGM) is a neutral heteropolysaccharide composed of glucose and mannose connected by β-1,4-glycosidic bonds. Its molecular structure is similar to that of dextran, and it has the ideal Many characteristics of biological materials: high hydrophilicity, good biocompatibility with biological macromolecules, rich in active hydroxyl groups in the molecules, and easy chemical modification, etc., so the prepared konjac glucomannan microspheres can be used as chromatographic media , drug controlled release carrier, fragrance adsorption carrier and other products. [0003] Because the development of konjac glucomannan microspheres has important economic and practical valu...

Claims

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Application Information

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IPC IPC(8): C08L5/02C08J3/24C08J3/16A61K47/36B01J13/02B01J13/14C11B9/00
Inventor 马光辉周炜清熊志冬苏志国李娟孙李靖巩方玲
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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