Dynamic measurement device and method for microcirculation metabolism of living tissue

Abstract

The invention discloses a dynamic measurement device and method for microcirculation metabolism of living tissue. The device comprises a multi-wavelength low-coherence light source, a beam expanding and Bessel transformation lens assembly, a microscopic imaging lens assembly, a high-speed CCD (charge coupled device) camera, a control circuit and a computer. With the adoption of the device and themethod, red cell velocity and metabolic state in human microcirculation can be monitored, the advantages of accuracy and rapidness are achieved, a blood-oxygen metabolism dynamic result with high spatial resolution and time resolution can be obtained, and powerful technical support is provided for diagnosis, long-term monitoring and therapeutic effect evaluation of acute and chronic diseases clinically.

Description

technical field [0001] The invention belongs to the technical field of optical imaging and component detection in the field of optical detection, and in particular relates to a dynamic measurement device and method for microcirculation metabolism of living tissue. Background technique [0002] Medical research shows that capillaries, venules, arterioles and lymphatic capillaries are places where blood, lymph and cell tissues exchange materials. Capillaries are the smallest part of microvessels, located between arterioles and venules, and are the most important part of material exchange between blood and tissue cells, so they are usually called microcirculation clinically. Microcirculation directly participates in the material, energy, and information transmission of tissues and cells, and plays a very important physiological role. Microcirculation function not only directly affects tissue metabolism, but also can reflect the progress of various chronic diseases. [0003] T...

AI Technical Summary

Problems solved by technology

This method can quantitatively analyze the local microcirculation blood flow velocity and flow change, but the time and space resolution is poor, and it also needs to scan point by point in the imaging area, the flow velocity resolution of a single red blood cell is poor, and the oxygen metabolism state cannot be measured

[0008] Confocal microscopy has high spatial resolution and can image a single red blood cell, but its range is small, and generally it can only image a single microvessel, and it needs to inject a contrast agent during the imaging process, which affects its clinical application. prospect

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