Dynamic measurement device and method for microcirculation metabolism of living tissue

A dynamic measurement, living tissue technology, used in diagnostic recording/measurement, medical science, sensors, etc., can solve the problems of poor temporal and spatial resolution, small range, inability to measure oxygen metabolism status, etc., to improve imaging resolution and Signal-to-noise ratio, the effect of reducing the effect of scattering

Inactive Publication Date: 2018-03-09
TIANJIN UNIV
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Problems solved by technology

This method can quantitatively analyze the local microcirculation blood flow velocity and flow change, but the time and space resolution is poor, and it also needs to scan point by point in the imaging area, the flow velocity resolution of a single red blood cell is poor, and the oxygen metabolism state ca

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  • Dynamic measurement device and method for microcirculation metabolism of living tissue
  • Dynamic measurement device and method for microcirculation metabolism of living tissue
  • Dynamic measurement device and method for microcirculation metabolism of living tissue

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Embodiment Construction

[0033] In order to make the technical problems, technical solutions and beneficial effects solved by the present invention clearer, the present invention will be further described in detail below in conjunction with the specific embodiments and with reference to the accompanying drawings.

[0034] see figure 1 , which shows a dynamic measurement device for microcirculation metabolism of living tissue in a specific embodiment of the present invention, which includes a computer 1, a control circuit 2, a 650nm low-coherence light source 3, a 407nm low-coherence light source 4, a 532nm low-coherence light source 5, and a beam and Bessel transformation lens group 7, mirror 8, sample holder 9, microscopic imaging lens group 10 and high-speed CCD camera 11.

[0035]During the imaging process, the sample is placed on the sample holder 9, the control circuit 2 controls the low-coherence light source 3, 4, 5 to switch through the TTL signal, and at the same time sends a trigger signal t...

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Abstract

The invention discloses a dynamic measurement device and method for microcirculation metabolism of living tissue. The device comprises a multi-wavelength low-coherence light source, a beam expanding and Bessel transformation lens assembly, a microscopic imaging lens assembly, a high-speed CCD (charge coupled device) camera, a control circuit and a computer. With the adoption of the device and themethod, red cell velocity and metabolic state in human microcirculation can be monitored, the advantages of accuracy and rapidness are achieved, a blood-oxygen metabolism dynamic result with high spatial resolution and time resolution can be obtained, and powerful technical support is provided for diagnosis, long-term monitoring and therapeutic effect evaluation of acute and chronic diseases clinically.

Description

technical field [0001] The invention belongs to the technical field of optical imaging and component detection in the field of optical detection, and in particular relates to a dynamic measurement device and method for microcirculation metabolism of living tissue. Background technique [0002] Medical research shows that capillaries, venules, arterioles and lymphatic capillaries are places where blood, lymph and cell tissues exchange materials. Capillaries are the smallest part of microvessels, located between arterioles and venules, and are the most important part of material exchange between blood and tissue cells, so they are usually called microcirculation clinically. Microcirculation directly participates in the material, energy, and information transmission of tissues and cells, and plays a very important physiological role. Microcirculation function not only directly affects tissue metabolism, but also can reflect the progress of various chronic diseases. [0003] T...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61B5/1455
CPCA61B5/0082A61B5/14551A61B5/4866A61B5/7235
Inventor 李晨曦陈文亮徐可欣
Owner TIANJIN UNIV
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