Garlicin flavoring agent and preparation method thereof

A technology of allicin and preparations, applied in pill delivery, pharmaceutical formulations, antiviral agents, etc., which can solve the problems of increasing the cost of garlic essential oil raw materials and complicated processes

Active Publication Date: 2018-03-16
BY HEALTH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method changes the extraction process, and the process is more complicated, which increases the cost of garlic essential oil raw materials, and the reaction is reversible, and there is still a small amount of odorous substances produced

Method used

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  • Garlicin flavoring agent and preparation method thereof
  • Garlicin flavoring agent and preparation method thereof
  • Garlicin flavoring agent and preparation method thereof

Examples

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Effect test

preparation example Construction

[0140] Preparation of Formulations and Methods of Administration

[0141] The allicin flavoring preparation of the invention contains a safe and effective amount of allicin-cyclodextrin complex and a pharmaceutically acceptable carrier or excipient. Such carriers include, but are not limited to: saline, buffer, dextrose, water, glycerol, ethanol, powders, and combinations thereof. The pharmaceutical formulation should match the mode of administration.

[0142] The pharmaceutical composition of the present invention can be made into tablets and capsules, which can be prepared by conventional methods, and the tablets and capsules should be manufactured under aseptic conditions. The dosage of the active ingredient is a therapeutically effective amount, such as about 1 microgram / kg body weight to about 50 mg / kg body weight, about 5 micrograms / kg body weight to about 10 mg / kg body weight, about 10 micrograms / kg body weight to about 5 mg / kg body weight per day. mg / kg body weight. ...

Embodiment 1

[0150] Allicin anion and cation flavoring tablets

[0151] Weigh the dried and sieved allicin-α-cyclodextrin crystals, respectively add chitosan as a cation, sodium carboxymethylcellulose as an anion, add magnesium stearate and micro silica gel, mix and press into tablets (Table 1 ).

[0152] Experimental results show that the flavored allicin sustained-release tablet with smoothness, no burrs and good formability can be formed; the tablet weight is 600-605mg, the hardness is 6.08kg, and the allicin is 10mg / tablet.

[0153] Table 1 Allicin Sustained Release Tablets Prescription Composition

[0154]

Embodiment 2

[0156] Allicin Sustained Release Tablets

[0157] Weigh the dried and sieved allicin-α-cyclodextrin crystals, respectively add chitosan as a cation, sodium cellulose as an anion, add magnesium stearate and micro silica gel, mix and press into tablets (Table 2).

[0158] The experimental results show that the flavored allicin sustained-release tablet with smoothness, no burrs and good formability can be formed; the tablet weight is 600-605mg, the hardness is 6.55kg, and the allicin is 10mg / tablet.

[0159] Table 2 Allicin Sustained Release Tablets Prescription Composition

[0160]

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Abstract

The invention relates to a garlicin flavoring agent and a preparation method thereof. Concretely, a garlicin-cyclodextrin compound is taken as a main component, and auxiliary materials with certain proportion are added to prepare the garlicin flavoring agent. The garlicin flavoring agent is not released in gastric juice and is completely released in intestinal juice, so that stimulation on gastricmucosa by garlicin or garlic essential oil and regurgitation phenomenon after eating a garlic product can be avoided. The method has the advantages of rapidity, simpleness, high efficiency, good security, and recyclable production, the used raw materials are cheap and easily available, and the method is benefit for industrial production.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to an allicin flavoring preparation and a preparation method thereof. Background technique [0002] Allicin is an active organic sulfur compound extracted from garlic head. Garlic essential oil contains allicin and other multi-component substances. The oil obtained by extracting and purifying garlic is garlic essential oil. Garlic essential oil and allicin have antibacterial, bactericidal, and virus-killing effects, and can lower blood fat, anticoagulant, prevent arteriosclerosis, prevent and treat cardiovascular and cerebrovascular diseases, and have extremely high health care value. [0003] Garlic essential oil and allicin are volatile, unstable, and highly irritating to human mucous membranes. Taste is also an important factor affecting drug compliance, which greatly limits the wide application of garlic in medicinal and edible products. Therefore, it has certain practical significa...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K9/20A61K9/22A61K9/28A61K9/48A61K47/38A61K47/36A61K47/32A61K31/255A61P31/04A61P31/12A61P3/06A61P7/02A61P9/10
CPCA61K9/0002A61K9/2027A61K9/205A61K9/2054A61K9/284A61K9/4866A61K31/255
Inventor 钱蔚冯静张继稳肖健郭桢彭辉方龙伟张旭光
Owner BY HEALTH CO LTD
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