Choline eutecticevaporate solvent, preparation method and application in extracting cytisine in trollius chinensis bunge

Abstract

The invention discloses a choline eutecticevaporate solvent, a preparation method and an application in extracting cytisine in trollius chinensis bunge. The invention provides the choline eutecticevaporate solvent of which the expression formula is [N(CH3)3CH2CH2OH]+[X.zY]-, and is prepared from choline chloride and oxalic acid or succinic acid according to a certain mole ratio through mixing. Byadopting the choline eutecticevaporate solvent disclosed by the invention, cytisine in trollius chinensis bunge can be efficiently extracted, compared with a conventional methanol solvent, the cholineeutecticevaporate solvent has an extraction rate increased by three times or greater, the raw material utilization rate is greatly increased, and the preparation cost of a pure cytisine product is reduced.

Description

technical field [0001] The invention belongs to the field of chemistry and medicine, and relates to the preparation and application of a deep eutectic solvent, in particular to a choline-type deep eutectic solvent, a preparation method and an application in extracting nasturtium nasturtium from nasturtium. Background technique [0002] In 2003, Abbott et al first discovered a kind of solvent—deep eutectic solvent (reference: Novel solvent properties of choline chloride / urea mixtures, Chem.Commun., 2003: 70 -71). This solvent is non-toxic, biodegradable, and the utilization rate of atoms in the synthesis process reaches 100%, which is a new type of green solvent. A deep eutectic solvent is usually a eutectic mixture composed of a certain stoichiometric ratio of quaternary ammonium salts and hydrogen bond donors (such as compounds such as amides, carboxylic acids, and polyols). [0003] Trollii Flos is the dried flower of Trollius chinensis Bunge, a plant of the family Ranun...

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Problems solved by technology

[0004] The monomeric pure product of nasturtium is usually obtained by extracting, separating and purifying nasturtium as raw material, but the extraction rate of nasturtium by existing extraction methods is low, taking methanol extraction as an example, about 0.5-1.1mg / g, the raw material utilization The rate is low (reference: HPLC determines the content of nasturtine in Trollius chinensis, Chinese Journal of New Drugs, 2012, Volume 37, No. 2)

Although Sun Qi etc. have provided a kind of method of chemically synthesizing tronosine, the final product of this method is the mixture of tronosine and its chiral isomer, and chiral resolution is difficult (references: Chemistry of tronosine Synthesis, Chinese Journal of New Drugs, Volume 25, Issue 11, 2016)

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