Preparation method of rouge radish extract and its application in the preparation of drugs for preventing and treating Alzheimer's disease
A technology of rouge radish and extract, applied in the field of Alzheimer's disease treatment, can solve the problems of few types of drugs, inability to block the pathogenesis of AD, poor drug efficacy, etc., and achieve the effect of improving cognition and memory ability
Active Publication Date: 2021-06-01
GUANGZHOU LIUSHUN BIO TEC CO LTD +1
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Problems solved by technology
There are two main problems in the current anti-AD drug research: one is that there are too few types of drugs to choose from, and there are only 5 marketed drugs so far, which are acetylcholinesterase inhibitors: tacrine (tacrine), donepezil (donepezil) ), rivastigmine, and galanthamine, as well as the N-methyl-D-aspartate receptor blocker memantine; the second is poor drug efficacy
The marketed drugs are only suitable for the symptomatic treatment of mild and moderate AD, and can only relieve the symptoms of AD, but cannot block the pathogenesis of AD
Method used
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Embodiment
[0018] The preparation of rouge radish extract comprises the steps:
[0019] S1: Wash the rouge radish and crush it with a grinder;
[0020] S2: Add the rouge radish fragments obtained in step 1 into the extraction tank, and add pure water into the extraction tank, wherein the mass of the rouge radish fragments (kg): volume of pure water (L) = 1:4; stir the rouge radish fragments , adjust the pH to 2-3 with dilute hydrochloric acid, and keep stirring for 30 minutes (better to extract the active ingredients);
[0021] S3: Filter the rouge radish pieces suspension in the extraction tank with a flat centrifuge at a speed of 1500r / min for 10 minutes to obtain the first filtrate; pour the filter residue back into the extraction tank, add pure water, and filter the residue Weight (kg): pure water volume (L) = 1:1. After the filter residue was stirred evenly, it was transferred to a plate centrifuge for filtration at a rotating speed of 1500r / min, and was filtered for 10 minutes to...
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The application relates to the technical field of Alzheimer's disease treatment, and discloses the application of rouge radish extract in the preparation of drugs for preventing and treating Alzheimer's disease. Through animal experiments, it was found that rouge radish extract can improve the cognitive and memory abilities of Alzheimer's disease model SAMP8 mice and D‑galactose model mice, and can be used in Alzheimer's disease drugs and other fields.
Description
technical field [0001] The application relates to the technical field of Alzheimer's disease treatment, in particular to a preparation method of rouge radish extract and its application in the preparation of drugs for preventing and treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive cognitive dysfunction and behavioral impairment that often occurs in old age, and is the most common type of senile dementia. Its main clinical features include progressive memory loss, cognitive dysfunction, behavioral disturbance, and decline in daily life ability. , sp); hyperphosphorylation of tau protein in brain nerve cells to form neurofibrillary tangles (neurofibrillary tangles, NFTs) in nerve cells; reduction of cerebral cortex nerve cells, and changes in neocortex and cerebral blood vessels. [0003] The Global Alzheimer's Disease 2011 Report released by the Internatio...
Claims
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IPC IPC(8): A61K36/31A61P25/28A23L33/105A61K125/00
CPCA23V2002/00A61K36/31A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A23L33/105A23V2200/322A23V2250/21A23V2300/14A23V2300/50A23V2300/10A23V2300/38
Inventor 刘兵戴静思邓联武钱学启杨利
Owner GUANGZHOU LIUSHUN BIO TEC CO LTD