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Application of orientin in preparation of drugs capable of resisting Mycobacterium tuberculosis

An anti-tuberculosis and tuberculosis technology, which is applied in the direction of antibacterial drugs, pharmaceutical formulas, and medical preparations containing active ingredients, can solve problems such as difficulties in tuberculosis prevention and treatment, and non-standardized treatment and management of tuberculosis patients. Strong inhibitory activity, outstanding substantive features, and broad application prospects

Inactive Publication Date: 2018-03-27
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of orientin in preparation of drugs capable of resisting Mycobacterium tuberculosis
  • Application of orientin in preparation of drugs capable of resisting Mycobacterium tuberculosis
  • Application of orientin in preparation of drugs capable of resisting Mycobacterium tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the preparation of compound Orientin tablet involved in the present invention:

[0019] Take 5 grams of compound Orientin, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0020] Embodiment 2: the preparation of the compound Orientin capsule involved in the present invention:

[0021] Take 5 grams of compound Orientin, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

experiment example 1

[0022] Experimental Example 1 Solid Medium Dilution Method Determination of Orientin Anti-Bacillus Calmette-Guerin (BCG) Absolute Concentration

[0023] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1) Turbidity, that is, to prepare 1 mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0024] Orientin is made into a high-concentration stock solution with DMSO, and the stock solution is diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted Orientin is added to 4ml Middlebrook7H11 agar medium (the The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly, and made to contain Orientin, the concentrations are 6.0ug / ml, 4.0ug / ml, 3.0ug / ml, 2....

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Abstract

The invention discloses application of orientin in preparation of drugs capable of resisting Mycobacterium tuberculosis. Currently, the incidence rate of tuberculosis is high, multi-drug resistant strains of Mycobacterium tuberculosis occur, and the morbidity and mortality of tuberculosis are on the rise; and orientin provided by the invention is found to have substantial activity in inhibition ofMycobacterium tuberculosis and has good application prospects. The application of orientin in preparation of drugs capable of resisting Mycobacterium tuberculosis is disclosed for the first time; since the skeleton type of orientin is a brand new skeleton type and the good activity of orientin in inhibition of Mycobacterium tuberculosis is unexpected, the application of orientin is developed without inspiration by any other compound, so the application of orientin has outstanding substantive distinguishing features; meanwhile, substantial progress is made as orientin is applied to preventionand treatment of infections caused by Mycobacterium tuberculosis.

Description

technical field [0001] The present invention relates to a new application of compound Orientin, in particular to the application of Orientin in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatment and mana...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/48A61K9/20A61P31/06
CPCA61K31/352A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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