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Efficient terminalization preparation method for hydroxyl terminal nano diamond for biological application

A nano-diamond, terminal technology, applied in diamond and other directions, can solve the problems of slow process, low yield of diamond nano-powder, inefficiency, etc., to achieve the effect of fast speed, shorten the free path of molecular motion, and avoid aggregation

Active Publication Date: 2018-03-27
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process of processing diamond nanopowder has low yield, slow process and low efficiency, and the aeration process is easy to take out toxic substances

Method used

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  • Efficient terminalization preparation method for hydroxyl terminal nano diamond for biological application
  • Efficient terminalization preparation method for hydroxyl terminal nano diamond for biological application
  • Efficient terminalization preparation method for hydroxyl terminal nano diamond for biological application

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0033] (1) Take a 100nm diamond powder sample and place it in HCl: H 2 SO 4 = Boil in a mixture of 1:5 for 2 hours, acid boil for 3 times, and then rinse with deionized water; then place in acetone solution and absolute ethanol for 15 minutes for ultrasonic cleaning, and place in a ventilated drying box to dry Ventilated drying at 60°C for 2 hours to obtain dry and pure nano-diamond powder. (2) 5g of nano-diamond powder, and 0.5mol / L Lithium Aluminum Hydride dissolved in THF solution are stirred into a suspension and placed in the reactor together to ensure that the volume of the mixed suspension is 80% of the volume of the reactor . (3) Assemble the reactor and close the outer steel jacket of the reactor. Then it was placed in a constant temperature heating box, and the temperature was set at 100°C. Start timing from reaching the set temperature, and set the constant temperature time to 1 hour. After the constant temperature time is terminated, when the temperature of th...

specific Embodiment approach 2

[0034] (1) Take a 100nm diamond powder sample and place it in HCl: H 2 SO 4 = Boil in a mixture of 1:5 for 2 hours, acid boil for 3 times, then rinse with deionized water; then place in acetone solution and absolute ethanol for ultrasonic cleaning for 10-15 minutes each, and place in a ventilated drying oven Air-dried at 100°C for 1 hour to obtain dry and pure nano-diamond powder. (2) 10g of nano-diamond powder is stirred with a solution of 1mol / L Lithium Aluminum Hydride dissolved in THF to form a suspension and placed in the reactor together to ensure that the volume of the mixed suspension is 80% of the volume of the reactor. (3) Assemble the reactor and close the outer steel jacket of the reactor. Then it was placed in a constant temperature heating box, and the temperature was set at 100°C. Start timing from reaching the set temperature, and set the constant temperature time to 2 hours. After the constant temperature time is terminated, when the temperature of the ste...

specific Embodiment approach 3

[0035] (1) Take a 100nm diamond powder sample and place it in HCl: H 2 SO 4 = Boil in a mixture of 1:5 for 2 hours, acid boil for 3 times, then rinse with deionized water; then place in acetone solution and absolute ethanol for ultrasonic cleaning for 10-15 minutes each, and place in a ventilated drying oven Air-dried at 200°C for 15 minutes to obtain dry and pure nano-diamond powder. (2) 15g of nano-diamond powder is stirred with a solution of 2mol / L Lithium Aluminum Hydride dissolved in THF to form a suspension and placed in the reactor together to ensure that the volume of the mixed suspension is 80% of the volume of the reactor. (3) Assemble the reactor and close the outer steel jacket of the reactor. Then it was placed in a constant temperature heating box, and the temperature was set at 100°C. Start timing from reaching the set temperature, and set the constant temperature time at 4 hours. After the constant temperature time is terminated, when the temperature of the...

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Abstract

The invention discloses an efficient terminalization preparation method for hydroxyl terminal nano diamond for biological application and belongs to the field of biological and medicinal functionalized basic material preparation. The method comprises the following process steps: a, performing mixed acid pickling, and washing a nano diamond powder turbid liquid to be neutral with deionized water; b, dissolving nano diamond powder and lithium aluminum hydride into a tetrahydrofuran solution, and putting into a high-temperature reaction kettle container till the volume of 60-90%; c, sealing an outer high-temperature reaction kettle steel sleeve, putting into a constant-temperature heating tank, and keeping a constant temperature; d, after a heat preservation time is met, cooling, taking out areaction after solution, and adding hydrochloric acid which does not react with diamond or tetrahydrofuran, but is used for dissolving metal ions instead; e, performing centrifugal separation, and washing the nano diamond powder with deionized water for multiple times till neutral without acid residue; and f, washing with acetone, and performing ethanol ultrasonic washing so as to obtain a hydroxyl terminal nano diamond turbid liquid, and performing dispersion purification, thereby obtaining high-quality hydroxyl terminal nano diamond. The method disclosed by the invention is convenient and simple and rapid in reaction velocity, and terminalization of a relatively large amount of nano diamond powder is achieved with solutions of same ratios and volumes.

Description

technical field [0001] The invention relates to the field of preparation of functional materials for biology and medicine. In particular, hydroxyl-terminated diamond is an excellent starting point for the further realization of diamond biofunctionalization. Through the high-temperature, high-pressure, sealed vapor-liquid self-stirring environment provided by the high-temperature reactor, the rapid, efficient and safe formation of hydroxyl-terminated diamonds on the diamond surface can be achieved, and discrete high-quality hydroxyl groups can be obtained. terminal nanodiamonds. technical background [0002] Nanoscale diamond particles have excellent mechanical and optical properties, high surface area and surface structure tunability, and the non-toxicity and biocompatibility of diamond make nanodiamonds have broad application prospects in biological applications. Colloidal suspensions prepared from discrete nanodiamond particles (single nanodiamonds) have been obtained and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/28
Inventor 李成明郑宇亭刘金龙魏俊俊黑立富陈良贤
Owner UNIV OF SCI & TECH BEIJING
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