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Paricalcitol liquid hard capsule and preparation method of same

A technology of paricalcitol and liquid hard capsules, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as poor patient compliance and inconvenient use of injections, and achieve convenience in taking and production. The process is green and environmentally friendly, and the effect is easy to carry

Inactive Publication Date: 2018-04-06
SINOPHARM CHUANKANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the injection is inconvenient to use, and the patient's compliance is poor

Method used

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  • Paricalcitol liquid hard capsule and preparation method of same
  • Paricalcitol liquid hard capsule and preparation method of same
  • Paricalcitol liquid hard capsule and preparation method of same

Examples

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Embodiment 1

[0039] This embodiment provides a paricalcitol liquid hard capsule, which mainly uses a hard capsule shell to fill the paricalcitol pharmaceutical composition. Wherein, the paricalcitol pharmaceutical composition is mainly made of 1 part of paricalcitol, 800 parts of absolute ethanol, 10 parts of dibutyl hydroxytoluene, and 100000 parts of medium-chain fatty acid triglyceride.

[0040] The present invention also provides a method for preparing paricalcitol liquid hard capsules, comprising adding dibutyl hydroxytoluene into absolute ethanol, stirring to dissolve, adding paricalcitol, and stirring to dissolve. Add the solution containing paricalcitol into the medium-chain fatty acid triglyceride, stir and mix evenly. Vacuumize and degas, pour into the hard capsule shell, and encapsulate the medicinal coating material at the capsule joint.

Embodiment 2

[0042] This embodiment provides a paricalcitol liquid hard capsule, which mainly uses a hard capsule shell to fill the paricalcitol pharmaceutical composition. Wherein, the paricalcitol pharmaceutical composition is mainly made of 4 parts of paricalcitol, 1500 parts of propanol, 20 parts of butylated hydroxyanisole and 290000 parts of coconut oil.

[0043] The present invention also provides a method for preparing paricalcitol liquid hard capsules, comprising adding butyl hydroxyanisole into propanol, stirring to dissolve, adding paricalcitol, and stirring to dissolve. Add the solution containing Paricalcitol to the coconut oil and stir to mix well. Vacuumize and degas, pour into the hard capsule shell, and encapsulate the medicinal coating material at the capsule joint.

Embodiment 3

[0045] This embodiment provides a paricalcitol liquid hard capsule, which mainly uses a hard capsule shell to fill the paricalcitol pharmaceutical composition. Wherein, the paricalcitol pharmaceutical composition is mainly made of 0.25 parts of paricalcitol, 750 parts of butanol, 8 parts of butylated hydroxyanisole and 50000 parts of isopropyl myristate.

[0046] The present invention also provides a method for preparing paricalcitol liquid hard capsules. Butylated hydroxyanisole is added to butanol, stirred to dissolve, then paricalcitol is added, and stirred to dissolve. Add the solution containing Paricalcitol into the isopropyl myristate, stir and mix well. Vacuumize and degas, pour into the hard capsule shell, and encapsulate the medicinal coating material at the capsule joint.

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Abstract

The invention relates to the field of pharmacy and particularly relates to a paricalcitol liquid hard capsule and a preparation method of same, wherein the paricalcitol liquid hard capsule is preparedmainly by using a hard capsule shell to coat a paricalcitol medicine composition, which comprises, by weight, 0.25-4 parts of paricalcitol, 720-1500 parts of lower alcohol solvent, 50000-290000 partsof an oil substrate, and 8-20 parts of an antioxidant. The liquid hard capsule is high in content uniformity and quality stability, has long shelf life and is high in bioavailability.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a paricalcitol liquid hard capsule and a preparation method thereof. Background technique [0002] Vitamin D is a fat-soluble vitamin. Two forms that are important in humans are: Ergocalciferol (vitamin D 2 ) and cholecalciferol (vitamin D 3 ). Vitamin D 3 Converted to 25(OH)D in the liver 3 . 25(OH)D 3 Transported from the liver to the kidney, and via 25-hydroxyvitamin D 31 - Hydroxylation by hydroxylase to form the active hormone paricalcitol. The active form maintains parathyroid function and calcium and phosphorus homeostasis by binding to the vitamin D receptor (VDR) found in the parathyroid glands, intestines, kidneys, and bone, as well as in many other tissues, including the prostate , endothelial and immune cells. Activation of the VDR is essential for proper formation and maintenance of normal bone. In the diseased kidney, vitamin D activation is reduced, leading to a ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/592A61K47/10A61K47/44A61K47/14A61P13/12A61P5/20
CPCA61K9/4825A61K9/4816A61K9/4858A61K31/592
Inventor 史焱彭熙琳樊永庆邓丽毛华谢天
Owner SINOPHARM CHUANKANG PHARMACEUTICAL CO LTD