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Method for preparing hydrogel dressing

A hydrogel and aqueous solution technology, applied in bandages, medical science, etc., can solve problems such as unsuitable for large-scale use in an environment that cannot guarantee wound moisture, complicated processes, etc., and achieve the effect of reducing the risk of wound exposure

Inactive Publication Date: 2018-04-17
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Among them, the temperature of the first method of melt spinning is high, which is easy to destroy the microcapsules, resulting in poor effect of energy storage and temperature regulation.
The second method has serious environmental pollution, there is a risk of wound exposure, and the wound cannot be guaranteed to be in a moist environment
In addition, the two methods are complicated and are not suitable for large-scale use

Method used

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preparation example Construction

[0014] The invention provides a kind of preparation method of hydrogel dressing, mainly comprises the following steps:

[0015] Step 1. Mix 1-8 parts by mass of silk fibroin aqueous solution and 3-6 parts by mass of aqueous polyurethane solution, add 1-5 parts by mass of polyvinyl alcohol aqueous solution, and react at a stirring rate of 500-700 for 20-30 minutes , to obtain a complex aqueous solution;

[0016] Wherein, the mass fractions of silk fibroin aqueous solution, aqueous polyurethane solution and polyvinyl alcohol aqueous solution are: 1-10%, 20-40% and 8-12.5% ​​respectively;

[0017] Step 2: Mix the phase-change energy storage microcapsules with the composite aqueous solution according to the mass ratio of 1:10-50, pour into a mold to solidify, and obtain a hydrogel dressing.

[0018] The preparation method of a hydrogel dressing provided by the present invention avoids the use of reagents that are not polluting and will not pollute the environment, and the method ...

Embodiment 1

[0026] 1. Weigh 15g of silk fibroin aqueous solution with a mass fraction of 10%, quickly pour it into 35g of a 40% aqueous polyurethane solution, stir magnetically for 20min, and slowly add 50g of a mass fraction of 12.5% ​​at room temperature The polyvinyl alcohol aqueous solution was reacted for 30 minutes at a stirring speed of 700 rpm to obtain a transparent silk fibroin / polyvinyl alcohol / polyurethane composite aqueous solution.

[0027] 2. Mix the phase-change energy storage capsules with a diameter of 30um and the composite aqueous solution prepared in step 1 according to the mass ratio of 1:50, stir, and ultrasonically disperse for 15 minutes to obtain a mixed solution.

[0028] 3. Pour the mixed solution obtained in step 2 into a 10mm×10mm×2mm square mold, freeze in a -25°C refrigerator for 8 hours, then thaw at room temperature for 4 hours, and freeze-thaw 5 times under this condition.

[0029] 4. Rinse the impurities on the surface of the thawed material with deioni...

Embodiment 2

[0032] 1. Weigh 20g of silk fibroin aqueous solution with a mass fraction of 5%, quickly pour it into 30g of a 40% aqueous polyurethane solution, stir magnetically for 15min, and slowly add 40g of a mass fraction of 10% at room temperature The polyvinyl alcohol aqueous solution was reacted for 25min at a stirring speed of 700rpm to obtain a transparent silk fibroin / polyvinyl alcohol / polyurethane composite aqueous solution.

[0033] 2. Mix the phase-change energy storage capsule with a diameter of 25um and the composite aqueous solution prepared in step 1 according to the mass ratio of 1:40, stir, and ultrasonically disperse for 15 minutes to obtain a mixed solution.

[0034] 3. Pour the mixed solution obtained in step 2 into a 10mm×5mm×1mm square mold, freeze in a -25°C refrigerator for 6 hours, then thaw at room temperature for 3 hours, and freeze-thaw 5 times under this condition.

[0035] 4. Rinse the impurities on the surface of the thawed material with deionized water, an...

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Abstract

The embodiment of the invention provides a method for preparing a hydrogel dressing and relates to the technical field of high polymer materials. The method comprises the following steps: mixing 1-8 parts by mass of a silk fibroin solution with 3-6 parts by mass of a waterborne polyurethane solution, adding 1-5 parts by mass of a polyvinyl alcohol solution, enabling the components to react for 20-30 minutes at a stirring velocity of 500-700rpm so as to obtain a composite solution, wherein the mass percentages of the silk fibroin solution, the waterborne polyurethane solution and the polyvinylalcohol solution are respectively 1-10%, 20-40% and 8-12.5%; and mixing phase-change energy storage microcapsules with the composite solution in a mass ratio of 1:(10-50), and curing in a mold, thereby obtaining the hydrogel dressing. The method is simple and applicable large-scale application.

Description

technical field [0001] The invention belongs to a method for preparing a hydrogel dressing, and relates to the technical field of polymer materials. Background technique [0002] As a wound cover, medical dressings can replace damaged skin as a temporary barrier during wound healing, play a role in controlling wound exudate, avoiding or controlling wound infection, and are conducive to wound healing. In recent years, the rapid development of science and technology has changed people's knowledge and understanding of the principles of wound healing and the process of wound care, and many new materials have been used in medical dressings on a large scale. For example, films, foams, hydrogels, alginates and hydrocolloids, and pharmaceuticals. Hydrogel dressings have excellent biocompatibility and strong water absorption, and will not cause adhesion to the wound when changing drugs. Therefore, applying hydrogel dressings to uneven wounds has good adhesion It can ensure the clea...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0052A61L26/0061A61L26/008C08L89/00C08L75/04C08L29/04
Inventor 陈少军王彩
Owner SHENZHEN UNIV