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A method for improving the water solubility of acetylisovaleryl tylosin tartrate

A technology of acetylisovaleryl tylosin tartrate and acetylisovaleryl tylosin, applied in chemical instruments and methods, organic chemistry, sugar derivatives, etc., can solve the inconvenience, acetylisovaleryl tylosin tartrate Can not be completely dissolved, affect the quality of the final product, etc., to achieve the effect of high yield, good water solubility and low cost

Active Publication Date: 2021-08-10
湖北回盛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of separation and purification directly affects the quality of the final product. Under the existing process conditions, acetylisovaleryl tylosin tartrate cannot be completely dissolved in tap water, which brings great inconvenience to pharmaceutical preparations and applications.

Method used

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  • A method for improving the water solubility of acetylisovaleryl tylosin tartrate
  • A method for improving the water solubility of acetylisovaleryl tylosin tartrate
  • A method for improving the water solubility of acetylisovaleryl tylosin tartrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A method for improving the water solubility of acetylisovaleryl tylosin tartrate, the steps are as follows:

[0037] (1) Take 100g of the crude extract of acetylisovaleryl tylosin, add 200ml of purified water, fully stir and disperse with a magnetic stirrer, and control the temperature at 30°C. After washing, use suction filtration to separate the solid from the liquid and collect the solid ;

[0038] (2) Disperse the collected solids again with 200ml of purified water by magnetic stirring, while controlling the temperature at 30°C. After washing, separate the solids and liquids by suction filtration, and collect the washed acetylisovaleryl tylosin;

[0039] (3) Add a little purified water to the washed acetylisovaleryl tylosin, cool down to 10°C, gradually add food grade L-tartaric acid to adjust the pH to 3.0, liquid phase detection and control of acetylisovaleryl tylosin The concentration of mycocin is 200000ppm;

[0040] (4) Add polyaluminum chloride with a soluti...

Embodiment 2

[0048] A method for improving the water solubility of acetylisovaleryl tylosin tartrate, the steps are as follows:

[0049] (1) Take 100g of the crude extract of acetylisovaleryl tylosin, add 350ml of purified water, fully stir and disperse with a magnetic stirrer, and control the temperature at 40°C. After washing, use suction filtration to separate the solid from the liquid, and collect the solid ;

[0050] (2) Magnetically stir and disperse the collected solids with 350ml of purified water again, while controlling the temperature at 40°C. After washing, separate the solids and liquids by suction filtration, and collect the washed acetylisovaleryl tylosin;

[0051] (3) Add a little purified water to the washed acetylisovaleryl tylosin, and cool down to 15°C, gradually add food grade L-tartaric acid to adjust the pH to 4.0, liquid phase detection and control of acetylisovaleryl tylosin The concentration of mycocin is 200000ppm;

[0052](4) Add polyaluminum chloride with a s...

Embodiment 3

[0060] A method for improving the water solubility of acetylisovaleryl tylosin tartrate, the steps are as follows:

[0061] (1) Take 100g of the crude extract of acetylisovaleryl tylosin, add 500ml of purified water, fully stir and disperse with a magnetic stirrer, and control the temperature at 50°C. After washing, use suction filtration to separate the solid from the liquid, and collect the solid ;

[0062] (2) Magnetically stir and disperse the collected solids with 500ml of purified water again, while controlling the temperature at 50°C. After washing, separate the solids and liquids by suction filtration, and collect the washed acetylisovaleryl tylosin;

[0063] (3) Add a little purified water to the washed acetylisovaleryl tylosin, cool down to 20°C, gradually add food grade L-tartaric acid to adjust the pH to 5.0, liquid phase detection and control of acetylisovaleryl tylosin The concentration of mycocin is 200000ppm;

[0064] (4) Add polyaluminium chloride with a sol...

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Abstract

The invention provides a process for extracting, purifying, and removing impurities from acetylisovaleryl tylosin tartrate to improve its water solubility. The steps include: first stirring and washing the crude acetylisovaleryl tylosin extract with purified water, Heat up to 30‑50°C while stirring, filter to obtain acetylisovaleryl tylosin water wash, repeat the above steps again, and the yield of the crude extract of 2 times of purified water wash is greater than 99%; then dissolve acetylisovaleryl with purified water Tylosin was washed with water, and while dissolving, tartaric acid was added to adjust the pH to 3-5, and the temperature was lowered to 10-20°C. After it was completely dissolved, polyaluminum chloride was added and a small amount of precipitation appeared. After standing still, it was obtained by solid-liquid separation with a decolorizing agent Clear, transparent and bright yellow solution; finally, dry and remove water to obtain the finished product of acetylisovaleryl tylosin tartrate, which is clear, transparent and light yellow after dissolving in tap water.

Description

technical field [0001] The invention belongs to the technical field of extraction and purification after antibiotics are produced by fermentation, and in particular relates to a process method for extracting, purifying, and removing impurities of acetylisovaleryl tylosin tartrate to improve its water solubility. Background technique [0002] Acetylisovaleryl Tylosin is an upgraded substitute product of Tylosin drugs widely used at home and abroad. As a new type of antibacterial drug, acetylisovaleryl tylosin is characterized by a wider antibacterial spectrum (special effect on tylosin-resistant bacteria) and higher antibacterial activity (activity is 3 times that of tylosin). -10 times), the dosage is small and the residue is low. It has a new molecular structure, bacteria are not easy to develop resistance to it, and it does not produce cross-resistance to antibiotics with similar chemical structures. Acetylisovaleryl Tylosin can be used to treat livestock and poultry dis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08C07H1/06
CPCC07H1/06C07H17/08
Inventor 戴军康远军高经纬郝康刘勇斌周泉刘洁
Owner 湖北回盛生物科技有限公司
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