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Application of acetamide in anti-psoriasis drugs

A technology of acetamide and psoriasis, applied in the application field of acetamide in anti-psoriasis drugs, can solve the problems that the application of acetamide in psoriasis has not been reported, and achieve the effect of improving cells and increasing thymus coefficient

Active Publication Date: 2020-07-10
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the application of acetamide to immune regulation and psoriasis has not been reported yet.

Method used

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  • Application of acetamide in anti-psoriasis drugs
  • Application of acetamide in anti-psoriasis drugs
  • Application of acetamide in anti-psoriasis drugs

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Embodiment Construction

[0032] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0033] Clinically, there are many medicines and health care products for enhancing immunity, including levamisole, astragalus polysaccharide, new bovine liver active peptide, etc. There are also many acetamide derivatives or compounds containing acetamide group, but there are few small molecular substances. And less.

[0034] For this reason, the present invention provides the application of acetamide in preparing immunomodulator, and the structural formula of described acetamide is:

[0035]

[0036] Acetamide alias acetate amide, molecular formula is CH 3 CONH 2 , the molecular weight is only 59.07. A compound produced by replacing the hydroxyl group in acetic acid with an amino group.

[0037] The dosage of the acetamide is 0.7-6g / kg, and the concentrati...

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PUM

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Abstract

The invention discloses application of acetamide in anti-inflammatory drugs, immunomodulators and anti-psoriasis drugs. Acetamide can strongly resist inflammation, IL-17F and TNF-alpha levels in serumare lowered remarkably, the expression of IL-22 is improved, showing that the acetamide has functions of anti-inflammation and immune suppression. The acetamide can adjust both nonspecific immunity and specific immunity, can increase a serum antibody generation level, increase levels of IL-1beta and IL-6 in serum and decrease the level of TNF-alpha in serum, and can increase the thymus coefficient remarkably. The acetamide can resist psoriasis strongly, and can decrease IL-17F and IL-23 in serum, wherein IL-17F and IL-23 are typical cell factors of psoriasis, and the acetamide can improve cells of the epidermis, spinous layer and dermis.

Description

technical field [0001] The invention relates to the technical field of immunomodulatory drugs, in particular to the application of acetamide in anti-psoriasis drugs. Background technique [0002] Immunity is usually divided into two types: innate immunity and adaptive immunity. Innate immunity has broad specificity and recognizes the conserved PAMP (pathogen-associated molecular pattern) in the recognition mechanism, and the receptor is PRR; adaptive immunity has very precise specificity and reflects the personality of pathogens. Features, the antigen recognition receptors are TCR and BCR. The innate immune response is the host's first line of defense against pathogenic microorganisms, and it initiates and participates in the adaptive immune response; adaptive immunity is the body's acquired, antigen-specific, and efficient defense mechanism against pathogenic microorganism infection. In recent years, the domestic immunology research team has closely connected basic immunol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/16A61P29/00A61P37/02A61P17/06
CPCA61K31/16
Inventor 臧林泉余伟
Owner GUANGDONG PHARMA UNIV
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