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Sharp slide ionization device based on electric tip spray and application of sharp slide ionization device

The technology of sharp glass ionization and sharp glass slide is applied in the field of sharp glass ionization device, which can solve the problems of analyte contamination and complex composition, and achieve the effects of anti-cross-contamination, easy construction and easy cleaning.

Inactive Publication Date: 2018-05-15
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] The object of the present invention is to solve the above-mentioned deficiencies and provide a tip slide ionization device based on tip electrospray, which has a simple structure, easy construction, convenient and fast operation, anti-cross-contamination, and can be conveniently used for direct ionization of sample solutions. Sample injection analysis solves the problem that the existing cutting-edge electrospray substrate materials such as filter paper, leaves, toothpicks, and tissue fibers have complex components and may cause certain pollution to analytes

Method used

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  • Sharp slide ionization device based on electric tip spray and application of sharp slide ionization device
  • Sharp slide ionization device based on electric tip spray and application of sharp slide ionization device
  • Sharp slide ionization device based on electric tip spray and application of sharp slide ionization device

Examples

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Embodiment 1

[0048] A tip slide ionization device capable of direct analysis of tip spray, comprising tip slide 1 and electrode 2; The injection port of 4 is aligned left and right, the tip is aligned with the injection port at an angle of 7.5° downward, and the tip slide 1 is 10 mm away from the injection port of mass spectrometer 3 . Then ground the electrode 2, and then drop the solution to be tested on the surface of the tip glass slide 1; the tip of the glass dropper is carefully polished with sandpaper until the tip thickness is ≤0.3mm and the width is ≤0.2mm; the electrode 2 is copper electrode; the mass spectrometer 3 is a Fourier transform mass spectrometer, which is produced by Bruker, Germany.

[0049] solariX 70FT-MS type, the mass spectrometry analysis conditions of the solariX 70FT-MS are as follows: set solariX70FT-MS to positive ion detection mode. Drying gas: flow rate 1.0ml / min, temperature 200°C; voltage 4.5kV, ion accumulation time 0.2sec, flight time 0.8ms. Other par...

Embodiment 2

[0057] A device that can realize direct analysis of tip spray, including a tip slide 1 and an electrode 2; the tip slide is fixed on the stage 3 and the height is adjusted, and the tip of the tip slide 1 is in use with the sample injection of the mass spectrometer 4 Align the mouth left and right, the tip is 7.5° obliquely down to the injection port, the tip slide 1 is 10mm away from the mass spectrometer 4 injection port, and then the electrode 2 is grounded, and then the solution to be tested is dripped on the tip slide 1 surface; The tip glass slide 1 is a glass dropper tip carefully polished to a thickness of 0.2mm and a width of 0.13mm through sandpaper; the electrode 2 is a copper electrode; the mass spectrometer 3 is a Fourier transform mass spectrometer, solariX 70FT from Bruker, Germany -MS type, the mass spectrometry analysis conditions of the solariX 70FT-MS are as follows: set the solariX 70FT-MS to negative ion detection mode: flow rate 1.0ml / min, temperature 200°C...

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PUM

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Abstract

The invention relates to a sharp slide ionization device based on electric tip spray and the application of the sharp slide ionization device. The ionization device comprises a sharp slide, an electrode and an objective table, wherein the sharp slide is made of glass and is cylindrical; a tip is arranged at the front end of the sharp slide; the sharp slide is placed on the objective table and fixed by a copper wire; the middle rear part of the sharp slide is wound with the copper wire as one end of the electrode; the other end of the electrode is grounded; the sharp slide is formed by grindingthe front end of a glass dropper with sand paper; the tip at the front end of the sharp slide is less than or equal to 0.3mm in thickness and less than or equal to 0.2mm in width; the tip of the sharp slide and a sample introduction port of a mass spectrometer are aligned at the right and left to form 1000-5000V voltage; and a distance between the tip of the sharp slide and the sample introduction port is greater than or equal to 10mm. The device is simple in structure, easy to construct, convenient and quick to operate and resistant to cross contamination, can be conveniently used for directsample introduction and analysis of a sample solution and solves the problem of certain contamination on an analyte due to complicated ingredients of filter paper, leaves, toothpicks and tissue fibers of the existing electric tip spray substrate materials.

Description

[technical field] [0001] The invention relates to the technical field of electrospray, in particular to a sharp slide ionization device based on tip electrospray and its application. [Background technique] [0002] Cutting-edge electrospray is a new type of mass spectrometry technology, which performs direct mass spectrometry analysis on samples in an open atmospheric pressure environment. This method uses the high voltage generated between the mass spectrometer and the grounded device to make the ions in the sample generate electrospray at the tip, ionize and enter the mass spectrometer inlet to realize mass spectrometry analysis. The cutting-edge spray technology does not require complicated sample preparation processes, does not require carrier gas to generate electrospray, and has the characteristics of high throughput, simplicity, real-time, rapidity, and low cost. At the same time, the tip spray also maintains the advantages of high sensitivity and high analysis speed...

Claims

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Application Information

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IPC IPC(8): G01N27/68
CPCG01N27/68
Inventor 许旭黄煜宇肖坤裴兴丽韩玉良龚灿
Owner SHANGHAI INST OF TECH
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