Polysulfone or polyether sulfone dialysis membrane and preparation method thereof

Abstract

The invention belongs to the technical field of medicine and discloses a polysulfone or polyether sulfone dialysis membrane and a preparation method thereof. The preparation method comprises: dissolving polyether sulfone in chloroform, filling with nitrogen, heating and stirring until full dissolution to obtain polyether sulfone solution, adding vorapaxar microspheres into the polyether sulfone solution, stirring well to obtain vorapaxar-modified polysulfone solution, washing many times with absolute ethyl alcohol, vacuum-drying to obtain vorapaxar-modified polyether sulfone, dissolving the vorapaxar-modified polyether sulfone in N,N-dimethylacetamide, stirring to obtain vorapaxar-modified polyether sulfone mixed solution, allowing standing, defoaming, performing water bath, and preparingvorapaxar-modified polyether sulfone membrane by means of immersion-precipitation phase transformation. The polysulfone or polyether sulfone dialysis membrane is modified with vorapaxar herein to improve antiplatelet and anti-clot performances of the membrane, so that a novel dialysis membrane material is synthesized.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a polysulfone or polyethersulfone dialysis membrane and a preparation method thereof. Background technique [0002] Blood purification based on hemodialysis and hemofiltration has become an important means of treatment for acute and chronic renal failure, systemic inflammatory response syndrome, severe pancreatitis and other critical diseases. The blood purifier is in direct contact with human blood, which is easy to induce blood coagulation and thrombus. In clinical practice, antithrombotic treatment must be routinely performed during blood purification. [0003] Currently, systemic use of antiplatelet or anticoagulants is a routine method for blood purification; however, most critically ill patients show a significant bleeding tendency, which is a contraindication for systemic antithrombotic therapy. Faced with the dilemma of not only preventing the coagulation of...

AI Technical Summary

Problems solved by technology

[0008] To sum up, the existing problems in the prior art are: the current modification of dialysis membranes is mainly to indirectly inhibit the activation of platelets by increasing their hydrophilic properties or anticoagulant properties, but there is no dialysis membrane that directly inhibits platelet activity;

[0012] At present, the new drugs grafted to dialysis membranes are basically grafted directly to the side branches of polysulfone or polyethersulfone membranes by chemical grafting, and the release of drugs is unstable.

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