Compound biological patch for repairing abdominal wall defects

Abstract

The invention belongs to the technical field of medical biological materials and discloses a compound biological patch for repairing abdominal wall defects. The compound biological patch is prepared from a biological patch layer and a bletilla striata fiber mesh layer which covers the surface of one side of the biological patch layer, wherein the bletilla striata fiber mesh layer is an electrospunnano-grade bletilla striata fiber mesh. According to the compound biological patch disclosed by the invention, the bletilla striata fiber mesh layer is combined with a traditional biological patch coating film, so that the anti-infection capability and the wound repairing capability of the compound biological patch are effectively improved; meanwhile, after the compound biological patch is implanted into an organism, the mechanical strength change is higher than needed mechanical strength all the time and tissue reconstruction can be accelerated; existing technical bottlenecks of the biological patch are conducive to solving and the treatment effect of repairing the abdominal wall defects is effectively improved.

Description

technical field [0001] The invention relates to a medical biological material, in particular to a medical biological patch. Background technique [0002] The development and application of bio-mesh is an important direction in the current research on hernia and abdominal wall surgery. Biological patch refers to a material that is taken from the same or heterogeneous tissue, removes various cells contained in the tissue after decellularization, and retains the three-dimensional framework structure of the extracellular matrix intact, and can be used to repair human soft tissue. According to the tissue source, it can be divided into allogeneic materials such as dermal acellular matrix, amniotic membrane, dura mater, etc., and heterogeneous materials such as pig small intestinal submucosa, cattle and horse pericardium, and bovine peritoneum. [0003] After the biological patch is implanted, with the growth of the host tissue, the biological patch is gradually degraded, and fina...

AI Technical Summary

Problems solved by technology

The reasons are nothing more than the following two reasons: 1. The biological patch degrades too quickly, while the tissue reconstruction is relatively slow, resulting in the composite mechanical curve of the two being lower than the mechanical strength of the abdominal wall at a certain stage

2. Although the biological patch degrades slowly, the tissue reconstruction is relatively insufficient, which eventually leads to repair failure

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