Application of a bisindole compound in the preparation of anti-inflammatory drugs

A compound, the technology of bisindole, applied in the field of pharmacy, can solve the problems of limited therapeutic effect and many toxic and side effects, and achieve the effects of improving cognitive impairment, inhibiting migration, and improving learning and memory ability.

Active Publication Date: 2019-11-15
HENAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Inflammation is the classic mechanism of dementia, but the existing anti-inflammatory drugs have limited therapeutic effect on dementia, especially vascular dementia, with many side effects

Method used

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  • Application of a bisindole compound in the preparation of anti-inflammatory drugs
  • Application of a bisindole compound in the preparation of anti-inflammatory drugs
  • Application of a bisindole compound in the preparation of anti-inflammatory drugs

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Embodiment Construction

[0023] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0024] Bis-indole compound 4ae described in the application can refer to literature (You-Qing Wang, Zhong-Shu Wei, Chao-Qun Zhu, Yuan-Yuan Ren, Chunrui Wu. Solvent-controlled and selectivesynthesis of mono- and bis-indolyl Products in Brønsted acid catalyzed aza-Friedel–Crafts reactions of indoles with cyclic imines. Tetrahedron. 2016; 72(31):4643-4654.) prepared.

[0025] Application test 1. Anti-inflammatory activity test of bisindole compound 4ae on zebrafish.

[0026] 1.1 Experimental instruments, materials and animals.

[0027] SZX16 stereo fluorescence microscope (Japan Olympus Optical Co., Ltd.); DP2-BSW image acquisition system (Japan Olympus Optical Co., Ltd.); X-51 inverted phase contrast microscope (Japan Olympus Optical Co., Ltd.) ; Zebrafish breeding system ...

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Abstract

The invention relates to application of di-indole compound (4ae) in preparing an anti-inflammation drug. A structural formula of the di-indole compound is shown as follows: (shown in the description).An inflammatory cell fluorescence labeled transgenic zebra fish is used for performing in-vivo pharmacodynamics experiment, and the compound is first discovered to have the activity for high efficiently inhibiting the migration of the inflammatory cell. A vascular dementia mice model is further utilized to discover that the compound can significantly improve the learning memory of the dementia mice, improve the pathologic change of the mice brain tissues and reflect higher anti-inflammation and antioxidant activity. In addition, the compound also has the activity for inhibiting acetylcholin esterase. The compound can be used for inflammatory related diseases and particularly has potential treatment advantage for the vascular dementia.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to the application of a bisindole compound in the preparation of anti-inflammatory drugs. Background technique [0002] With the aging of the population and changes in diet structure in China, the incidence of cerebrovascular diseases has been increasing year by year, among which the number of patients with vascular dementia has increased significantly. The quality of life of dementia patients is significantly reduced, and the family burden is relatively large. The social security system cannot fully cover this elderly group. In contrast, there are still no effective intervention methods and therapeutic drugs for this disease at home and abroad. [0003] Dementia is mainly manifested as cognitive impairment, mainly including: senile dementia (Alzheimer's Disease, AD) and vascular dementia (Vascular Dementia, VD). In recent years, studies have shown that: vascular risk...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/404A61P29/00A61P39/06A61P25/28
CPCA61K31/404
Inventor 岑娟张峰郑贝贝方昊陈梦莹贾智莉李晓娅邹玉汪游清姬汴生
Owner HENAN UNIVERSITY
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