Application of a bisindole compound in the preparation of anti-inflammatory drugs
A compound, the technology of bisindole, applied in the field of pharmacy, can solve the problems of limited therapeutic effect and many toxic and side effects, and achieve the effects of improving cognitive impairment, inhibiting migration, and improving learning and memory ability.
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[0023] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.
[0024] Bis-indole compound 4ae described in the application can refer to literature (You-Qing Wang, Zhong-Shu Wei, Chao-Qun Zhu, Yuan-Yuan Ren, Chunrui Wu. Solvent-controlled and selectivesynthesis of mono- and bis-indolyl Products in Brønsted acid catalyzed aza-Friedel–Crafts reactions of indoles with cyclic imines. Tetrahedron. 2016; 72(31):4643-4654.) prepared.
[0025] Application test 1. Anti-inflammatory activity test of bisindole compound 4ae on zebrafish.
[0026] 1.1 Experimental instruments, materials and animals.
[0027] SZX16 stereo fluorescence microscope (Japan Olympus Optical Co., Ltd.); DP2-BSW image acquisition system (Japan Olympus Optical Co., Ltd.); X-51 inverted phase contrast microscope (Japan Olympus Optical Co., Ltd.) ; Zebrafish breeding system ...
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