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Single-voxel localized 1-D high-resolution homonuclear decoupling spectrum method

A high-resolution, high-resolution technology, applied in the field of nuclear magnetic resonance spectroscopy detection, can solve problems such as spectral peak crowding, spectral peak signal attribution, and signal quantification troubles, and achieve phase distortion elimination, wide applicability, and hyperspectral The effect of resolution

Inactive Publication Date: 2018-06-01
XIAMEN UNIV
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Problems solved by technology

These two methods can obtain localized spectral information well, but the signals collected by them all have the problem of spectral peak splitting caused by J-coupling and spectral peak crowding, which has a relatively large impact on the assignment of spectral peak signals and signal quantification. big trouble

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Embodiment Construction

[0020] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0021] A single voxel localized one-dimensional high-resolution homonuclear decoupling spectroscopy method, comprising the following steps:

[0022] 1) Construct the z-filter module and write the sampling sequence code, add a 180-degree adiabatic linear sweep chirp pulse and a gradient G applied at the same time after the conventional two-dimensional localized coherent spectrum, the duration of the chirp pulse and gradient G are equal, and the gradient The amplitude of G remains constant, and a 90-degree selective pulse applied at the end flips the magnetization vector in the z direction to the xy plane for detection;

[0023] 2) Set the sweep range, duration and corresponding gradient G of the chirp pulse according to the selected voxel size of the measured sample and the spectral bandwidth used;

[0024] 3) Put the measured sample into the d...

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Abstract

The invention provides a single-voxel localized 1-D high-resolution homonuclear decoupling spectrum method, and relates to a magnetic resonance apparatus. On the basis of a traditional 2D localized correlated spectroscopy, the method adds linear adiabatic sweep (chirp) pulses and gradients applied at the same time to form a z-filter module that can effectively suppress a zero-quantum coherent pathand other paths so as to obtain a pure Lorentz absorption linetype nuclear magnetic resonance spectrum. The selection of voxels is accomplished together by selective pulses combined with selection layers and destruction gradients. The post-processing of the experimentally acquired data can yield a 1-D spectrum with only chemical shift information. The 1-D localized spectrum obtained by the invention can eliminate the phase distortion caused by the zero quantum coherence, thereby having the advantages of high spectral resolution and the like. This method can be used for the study of the biological tissue and living body localized spectrum to obtain more concise and perfect spectral information, so that the localized spectrum has a wider range of applications.

Description

technical field [0001] The invention relates to a detection method in nuclear magnetic resonance spectroscopy, in particular to a single-pixel one-dimensional localized spectrum method. Background technique [0002] Magnetic Resonance Spectroscopy (MRS) is a non-destructive detection technique for obtaining biochemical quantitative information and diagnostic information in vivo. It is a powerful complementary technique to Magnetic Resonance Imaging (MRI), which is helpful for clinical diagnosis and disease prediction, as well as animal research. MRS can selectively and non-invasively measure the chemical composition and structure in the tissue, the change of the chemical environment and the existing form of molecules in the living body. This information is a bridge between biochemical changes and disease pathology, which is beyond the reach of any previous imaging technology. acquired. Localized MRS refers to the use of gradient fields and pulses to selectively excite a sma...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/46G01R33/28
CPCG01R33/28G01R33/4625
Inventor 林雁勤段博田丹陈忠
Owner XIAMEN UNIV
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