Stent of medicine coating

A drug coating and drug technology, applied in the field of medical devices, can solve the problem that endothelial cells cannot be completely covered, and achieve the effect of inhibiting restenosis and inhibiting proliferation

Inactive Publication Date: 2018-06-22
NANJING DRUM TOWER HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the follow-up of patients implanted with these drug-eluting stents found that the incomplete coverage of advanced endothelial cells became the biggest disadvantage of this drug-eluting stent

Method used

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  • Stent of medicine coating

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Effect test

Embodiment Construction

[0017] 1.1 Experimental materials

[0018] 1.1.1 Cell lines and main reagents: porcine bone marrow stem cells, fetal bovine serum, DMEM medium, EBM-2 medium, PDGF-BB growth factor, PBS, trypsin, FITC, DAPI nuclear fuel, MTT, DMSO.

[0019] 1.1.2 Drugs, carriers and stents: gefitinib, polylactic acid, 100% ethanol, 3cm*2.5mm coronary balloon expansion stent (Buma)

[0020] 1.1.3 Experimental animals: This experiment uses Bama miniature pigs, male or female, weighing 20-25kg, purchased from the Animal Experiment Center of Nanjing Drum Tower Hospital

[0021] 1.2 Experimental method

[0022] 1.2.1 Induction of vascular smooth muscle cells and vascular endothelial cells and identification by immunofluorescence: Normal-growing porcine bone marrow stem cells were cultured in DMEM medium and EBM-2 medium containing PDGF-BB growth factor respectively, and the parameters of the cell culture box were Adjusted to 5% CO 2 , and the ambient temperature was adjusted to 37°C. Induced to ...

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Abstract

The invention relates to an intravascular stent containing a medicine coating. An intravascular stent base body is made of bare metal or alloy; a gefitinib medicine coating is covered on the intravascular stent. Gefitinib medicine and a polylactic acid carrier form the coating; the mass ratio of the gefitinib medicine to the polylactic acid carrier is 5mg/g. The gefitinib and the carrier of the polylactic acid are dissolved in a 100-weight-percent ethanol solution; heating is performed to 40 to 80 DEG C; the temperature is maintained for one hour or more; a metal stent base body is fixed and is maintained at 60+/-10 DEG C; medicine coating liquid is dropped on the stent base body to be dried; the operations are repeated for 3 to 10 times until the coating thickness reaches 10 to 100 micrometers through dropping; or the metal stent is soaked in the medicine coating liquid; then, drying is performed to form the coating; the operations are repeated for 3 to 10 times until the required coating thickness is reached.

Description

technical field [0001] The invention relates to a medical device, which is a drug-loaded stent formed by loading a functional drug coating on a common stent base material composed of common CoPt, stainless steel and other alloy grids. Background technique [0002] US Patent No. 5697967 discloses such a drug-loaded stent. US Patent No. 9204982 discloses a method for injecting drugs into this type of stent. The application of rapamycin on bare stents in blood vessels can effectively inhibit the occurrence of restenosis. Most of the peripheral stents currently used clinically are bare metal stents, but stent implantation has long been limited by in-stent restenosis (ISR). In-stent restenosis (ISR) occurs in ~30% of patients, which has become an important problem in interventional therapy[1]. Studies have shown that drug-eluting stents (DES) can further reduce the incidence of ISR[2], but DES still faces late stent thrombosis (LST), very late stent thrombosis (very late sten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/16A61K31/5377A61P9/10
CPCA61K31/5377A61L31/022A61L31/08A61L31/10A61L31/16A61L2300/204A61L2300/416A61L2300/602A61L2420/02A61L2420/06C08L67/04
Inventor 冉峰赵琪卓华威
Owner NANJING DRUM TOWER HOSPITAL
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