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Andrographolide and extraction method thereof

A technology of andrographolide and extraction method, applied in the direction of organic chemistry, etc., can solve the problems of drug stability, human hazards, health and safety impacts, toxic reagents are difficult to remove, etc., to reduce adverse effects, reduce the content of related impurities, Improved security and stability effects

Inactive Publication Date: 2018-07-03
四川文龙药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing technology not only affects the health of the production workers and the safety of the production process in the production process, but also the toxic reagents are not easy to remove completely, which greatly harms the stability of the drug and the human body. At the same time, the total yield is too low, and the product higher cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The extraction method of andrographolide, comprises the following steps,

[0036] S1-extraction, the original leaves of Andrographis paniculata were ultrafinely pulverized to 200 meshes, added with 95% medicinal ethanol for countercurrent extraction, and filtered (in this example, a stainless steel plate was used for pressure filtration) to obtain an extract.

[0037] S2-coarse crystal, add medicinal activated carbon to the extract, heat to boiling and stir for 2 hours to decolorize, and the whole decolorization process is in a nitrogen environment. Filtration (in this example, a stainless steel plate was used for pressure filtration), the filtrate was concentrated under reduced pressure, and the concentrated solution was crystallized at minus 10°C to obtain coarse crystals.

[0038] S3-Recrystallization, add 95% medicinal ethanol and medicinal activated carbon to the coarse crystal, heat to boiling and stir for 2 hours to decolorize, and the whole decolorization proces...

Embodiment 2

[0043] The extraction method of andrographolide, comprises the following steps,

[0044] S1-extraction, the original leaves of Andrographis paniculata were ultrafinely pulverized to 120 mesh, added with 95% medicinal ethanol for countercurrent extraction, and filtered (in this embodiment, a stainless steel plate was used for pressure filtration) to obtain the extract.

[0045] S2-coarse crystal, add medicinal activated carbon to the extract, heat to boiling and stir for 2 hours to decolorize, and the whole decolorization process is in a nitrogen environment. Filtration (in this example, a stainless steel plate was used for pressure filtration), the filtrate was concentrated under reduced pressure, and the concentrated solution was crystallized at minus 15°C to obtain coarse crystals.

[0046]S3-Recrystallization, add 95% medicinal ethanol and medicinal activated carbon to the coarse crystal, heat to boiling and stir for 2 hours to decolorize, and the whole decolorization proce...

Embodiment 3

[0050] The extraction method of andrographolide, comprises the following steps,

[0051] S1-extraction, the original leaves of Andrographis paniculata were ultrafinely crushed to 80 meshes, added with 95% medicinal ethanol for countercurrent extraction, and filtered (in this embodiment, a stainless steel plate was used for pressure filtration) to obtain an extract.

[0052] S2-coarse crystal, add medicinal activated carbon to the extract, heat to boiling and stir for 2 hours to decolorize, and the whole decolorization process is in a nitrogen environment. Filtration (in this example, a stainless steel plate was used for pressure filtration), the filtrate was concentrated under reduced pressure, and the concentrated solution was crystallized at minus 8°C to separate and obtain coarse crystals.

[0053] S3-Recrystallization, add 95% medicinal ethanol and medicinal activated carbon to the coarse crystal, heat to boiling and stir for 2 hours to decolorize, and the whole decoloriza...

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PUM

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Abstract

The invention provides an extraction method of andrographolide. The extraction method is characterized by smashing andrographis paniculate raw leaves, extracting with ethanol, and filtering to obtainan extracting solution; charging nitrogen into the extracting solution, heating, stirring, decoloring, and performing low temperature crystallization to obtain coarse grains; charging nitrogen into the coarse grains, heating, stirring, decoloring, crystallizing, and separating to obtain recrystals; repeating the step for multiple times to obtain andrographolide; and washing, drying, smashing and packaging into finished products. The andrographolide prepared by adopting the method does not contain toxic reagent, and is high in safety, high in purity and high in yield.

Description

technical field [0001] The present invention relates to andrographolide and its extraction method. Background technique [0002] Andrographis paniculata (Andrographis paniculata (Burm.F.) Nees) is the dry aerial part of the Acanthaceae plant. It is harvested when the stems and leaves are luxuriant in early autumn and dried in the sun. Andrographis paniculata, also known as spring lotus and autumn willow, is a joy at first sight, Lamicarpa, bitter gall grass, golden vanilla, golden ear hook, Indian grass, bitter grass and so on. It has the effects of clearing away heat and detoxification, reducing inflammation, reducing swelling and relieving pain. It is mainly used to treat bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngitis, pneumonia and influenza, etc. It can be used externally to treat sores, furuncles, swollen toxins, and traumatic infections. Mainly produced in Guangdong, Fujian and other provinces, there are also introductions in ...

Claims

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Application Information

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IPC IPC(8): C07D307/60
CPCC07D307/60
Inventor 张迎春
Owner 四川文龙药业有限公司
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