Total flavonoids from waxberry, preparation method and application of total flavonoids from waxberry, and eNOS agonist

A technology for extracting total flavonoids and solvents, applied in the field of its preparation, total flavonoids of myrica rubra, eNOS agonists, can solve the problems of reducing the protection of the vascular system, weakening of biological activity, etc., and achieve high purity, increased expression, and better effects

Pending Publication Date: 2018-07-13
WUHAN WORLDNER UNITED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These several mechanisms leading to endothelial dysfunction are not mutually exclusive and may occur concurrently, with a common feature of reduced biological activity of NO and thus reduced protection of the vasculature

Method used

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  • Total flavonoids from waxberry, preparation method and application of total flavonoids from waxberry, and eNOS agonist
  • Total flavonoids from waxberry, preparation method and application of total flavonoids from waxberry, and eNOS agonist
  • Total flavonoids from waxberry, preparation method and application of total flavonoids from waxberry, and eNOS agonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Weigh 100g of red bayberry dry powder, add 800ml of 95% ethanol to extract twice, the extraction time is 2h, filter the extract, combine the filtrates, concentrate under reduced pressure to obtain extract, namely total flavonoids of red bayberry.

Embodiment 2

[0060]Weigh 100g of red bayberry dry powder, add 1000ml of 80% ethanol to extract twice, the extraction time is 2h, filter the extract, combine the filtrates, concentrate under reduced pressure to obtain extract, namely total flavonoids of red bayberry.

Embodiment 3

[0062] Weigh 100g of red bayberry dry powder, add 800ml of 95% ethyl acetate to extract twice, the extraction time is 3h, filter the extract, combine the filtrates, concentrate under reduced pressure to obtain extract, namely total flavonoids of red bayberry.

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Abstract

The invention relates to the field of medicines and healthcare products, and provides total flavonoids from waxberry, a preparation method and application of the total flavonoids from waxberry, and aneNOS agonist. The total flavonoids from waxberry have effects of up-regulating expression of eNOS and improving activity of eNOS; the total flavonoids from waxberry are used as the eNOS agonist, areapplied to preparation of medicines for treating eNOS-mediated diseases, and can effectively treat diseases caused by endothelial dysfunction; the preparation method of the total flavonoids from waxberry comprises the following steps: taking 100-150 parts by weight of waxberry, crushing, adding 500-1200 parts by weight of an extraction solvent for extracting 1-3 times for 60-120 min each time, andfiltering, combining and concentrating extracts obtained in several times, wherein the extraction solvent comprises ethanol and/or ethyl acetate. The preparation method is simple; the obtained totalflavonoids from waxberry are high in yield and purity; a final product is safe and liable; and the eNOS agonist containing the total flavonoids from waxberry can effectively treat the diseases causedby endothelial dysfunction.

Description

technical field [0001] The invention relates to the field of medicines and health care products, in particular to a total flavonoids of myrica rubra, its preparation method and application, and an eNOS agonist. Background technique [0002] Nitric oxide (NO) is a second messenger molecule with high free radical activity, which plays an important role in the maintenance of vascular tone and the stable regulation of blood pressure. Studies have shown that NO is mainly produced in two ways: non-enzymatic and enzymatic. The former is mainly produced by donors such as nitroglycerin and sodium nitroprusside, while the latter must have the participation of enzymes and mainly depends on nitric oxide synthase (nitric oxide synthase, NOS) produced. Because NO is extremely unstable in the body, the research on NOS will greatly promote the research on NO-related functions. NOS is an isoenzyme, which is mainly divided into three subtypes, namely endothelial NOS (endothelial nitric oxid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P9/12A61P9/10A61P13/12A61P3/10
CPCA61K36/185A61K2236/19A61K2236/33A61K2236/39
Inventor 丁虹李建李晓斐杜思达
Owner WUHAN WORLDNER UNITED PHARMA
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