Preparation method of micromolecular selenylation carrageenan with high selenium content

A technology of selenized carrageenan and small molecules, which is applied in the functions of food ingredients, food ingredients, food science, etc., can solve the problems of low biological activity, unfavorable absorption, low selenium content, etc., and achieve high biological activity, easier absorption, The effect of low molecular weight

Active Publication Date: 2018-07-13
青岛鑫康达生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Selenized carrageenan is a kind of organic selenium, its toxicity is far lower than that of inorganic selenium, it has good solubility and is easy to absorb. It has been used in the food industry as a food additive, but currently the food-grade selenized carrageenan synthesized in China is a macromolecular selenium polysaccharide , the molecular weight is around 20,000, which is not conducive to human body absorption, the selenium content is low, and the biological activity is low

Method used

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  • Preparation method of micromolecular selenylation carrageenan with high selenium content
  • Preparation method of micromolecular selenylation carrageenan with high selenium content
  • Preparation method of micromolecular selenylation carrageenan with high selenium content

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Embodiment 1

[0038] Degradation of carrageenan: 50g of carrageenan is made into a 5% sol at 70°C, and a mixed acid solution of nitric acid and hydrochloric acid is added under stirring, the H+ concentration is 0.8mol / L, and the temperature is maintained, and 1000w microwave is continued for 10 minutes to make the solution molecules resonate Reach the active state, use the ultrasonic breaker for resonance, degrade for 30 minutes, adjust the pH to neutral,

[0039] Refining of small molecule carrageenan fragments: use nanofiltration membrane with a molecular weight cut-off of 3000 Daltons to remove molecular fragments with a molecular weight greater than 3000, retain the filtrate, and filter the filtrate through a nanofiltration membrane with a molecular weight of 500 Daltons to filter out molecular fragments with a molecular weight lower than 500 small molecule fragments and inorganic salts to obtain a small molecule carrageenan solution with a molecular weight of 500-3000 Daltons, and dry t...

Embodiment 2

[0054] Degradation of carrageenan: 6g carrageenan is made into a 5% sol at 80°C, and a mixed acid solution of nitric acid and sulfuric acid is added under stirring. In the active state, use a sonicator for resonance, degrade for 60 minutes, adjust the pH to neutral,

[0055] Refining small molecule carrageenan fragments: use nanofiltration membrane with a molecular weight cut-off of 3000 Daltons to remove molecular fragments with a molecular weight greater than 3000, retain the filtrate, and pass the filtrate through a nanofiltration membrane with a molecular weight of 500 Daltons to filter out molecular fragments with a molecular weight lower than 500 small molecule fragments and inorganic salts to obtain a small molecule carrageenan solution with a molecular weight of 500-3000 Daltons, and freeze-dry to obtain 6.7 g of small molecule carrageenan fragments;

[0056] Sulfation reaction: Prepare the esterification agent according to the chlorosulfonic acid-pyridine method, add ...

Embodiment 3

[0063] Degradation of carrageenan: 80g of carrageenan is made into a 5% sol at 90°C, and a mixed acid solution of nitric acid and sulfuric acid is added under stirring, the H+ concentration is 1.5mol / L, and the temperature is kept, and the 1200w microwave is continued for 30 minutes to make the solution molecules resonate Reach the active state, use the ultrasonic breaker for resonance, degrade for 120 minutes, adjust the pH to neutral,

[0064] Refining small molecule carrageenan fragments: use nanofiltration membrane with a molecular weight cut-off of 3000 Daltons to remove molecular fragments with a molecular weight greater than 3000, retain the filtrate, and pass the filtrate through a nanofiltration membrane with a molecular weight of 500 Daltons to filter out molecular fragments with a molecular weight lower than 500 small molecule fragments and inorganic salts to obtain a small molecule carrageenan solution with a molecular weight of 500-3000 Daltons, and freeze-dry to o...

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Abstract

The invention discloses a preparation method of micromolecular selenylation carrageenan with a high selenium content. The preparation method particularly comprises the following steps: performing specific-power ultrasonic treatment and ultrasonic assistance on carrageenan macromolecules to rapidly realize quantitative degradation of carrageenan molecule segments, wherein the molecular weight of most of the carrageenan is 500 to 3000 Daltons, and the carrageenan degradation time is greatly shortened when being compared with the traditional carrageenan degradation time; performing sulphating reaction to esterify carrageenan polysaccharide, and adding barium chloride and seleninic acid and performing microwave and ultrasonic assistance to promote selenylation reaction, so that the time is greatly shortened when being compared with the time of the traditional process, rapid and efficient selenylation effect can be achieved, the selenylation carrageenan with high selenium content and low molecular weight is finally prepared, the bioavailability of the selenylation carrageenan is improved, and the efficiency of absorbing the selenium by the organism is improved.

Description

technical field [0001] The invention relates to a method for preparing selenized carrageenan with low molecular weight and high selenium content, in particular to a method for obtaining small molecule selenized carrageenan with high selenium content through a series of treatments using carrageenan as a raw material. Background technique [0002] Selenium is an essential trace element for humans and animals. It is known as "the fire of life", "the king of anti-cancer", and "the patron saint of the heart". It is an important component of some antioxidant enzymes and selenium-P protein in the human body Part of it plays an important role in human life activities. People can improve the body's immunity, disease resistance and delay aging through selenium supplementation. Since there is no long-term selenium storage organ in the human body, the selenium needed by the body should be continuously obtained from the diet in sufficient amounts. The balance of selenium concentration ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J11/10C08B37/00A23L33/125C08L5/00
CPCA23L33/125A23V2002/00C08B37/0042C08J11/10C08J2305/00A23V2200/30A23V2250/5036Y02W30/62
Inventor 张正兴任媛媛潘惟谦杜吉勇刘国强
Owner 青岛鑫康达生物科技有限公司
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