Quick and precise high-throughput drug screening system based on deep learning

Abstract

The invention discloses a quick and precise high-throughput drug screening system based on deep learning. The drug screening system comprises a picture preprocessing module and a neural network module, wherein the picture preprocessing module comprises a channel merging module and a picture standardization module; the channel merging module merges different cell single-color channel pictures intothe multi-channel picture representation, wherein the merged picture tensors are represented as [H,W,C]; the picture standardization module standardizes the input multi-channel picture data into the tensor representation of [70,70,C]; the neural network module is connected with the picture standardization module, the input data of the neural network module is standardized picture tensors, and finally the trained neural network is subjected to final prediction classification prediction. The drug screening system DeepScreen based on deep learning has the advantages of being high in throughput, precise, efficient, fast, convenient, low in cost and resistant to interference, and has a worth-concerning practical and application prospect.

Description

technical field

[0001] The invention relates to the technical field of biomedicine, specifically, a fast, accurate and high-throughput drug screening system based on deep learning. Background technique

[0002] According to statistics, it takes 10-14 years and more than 200 million U.S. dollars for each new drug to go on the market, from testing to marketing. How to speed up the discovery and testing of new drugs has always been the key and difficulty in accelerating the drug R&D stage. In recent years, the development of biochemistry, physiopathology and other disciplines has provided new means of drug screening, and some drug screening models at the molecular and cellular level have emerged, and with the development of more advanced detection technology, automation technology and computer technology, In the late 1990s, a high throughput screening technology (High throughput screening, HTS) was developed. HTS mainly relies on automated operating systems, namely laboratory ...

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