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Traditional Chinese medicinal combined extract and application thereof

A technology of extracts and traditional Chinese medicines, applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as unreported prevention or treatment of vascular diseases, and achieve the effects of low cost and small side effects

Inactive Publication Date: 2018-07-24
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern studies have shown that rhubarb, berberine and scutellaria baicalensis have antibacterial, anti-inflammatory, insecticidal, anti-cancer, and purgative effects, but their effects on the prevention or treatment of vascular diseases induced by hypertension have not been reported at home and abroad

Method used

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  • Traditional Chinese medicinal combined extract and application thereof
  • Traditional Chinese medicinal combined extract and application thereof
  • Traditional Chinese medicinal combined extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Identification method of rhubarb, Coptidis rhizome and Scutellaria baicalensis combined extract:

[0031] Preparation of the test solution: take 2 parts of rhubarb, 1 part of berberine, and 1 part of skullcap, add 240ml of ultrapure water, and decoct to about 80ml. Filter through two layers of gauze, and the filtrate is adjusted to 100ml. Precisely pipette 500μl into a 10ml volumetric flask, add methanol to the volume, place it at room temperature after ultrasonication for 10min, add methanol to make up to the volume, and filter through a 0.22μm microporous membrane. Take the continued filtrate to obtain the test solution.

[0032] Preparation of standard solution: Preparation of reference solution Take 10 mg each of baicalin, berberine, wogonin and aloe-emodin reference substances, weigh them accurately, put them in a 100ml measuring bottle, dissolve them with methanol and dilute to the mark, shake well , Accurately measure 10ml, put it in a 25ml measuring bottle,...

Embodiment 2

[0053] The combined extracts of rhubarb, coptis and scutellaria baicalensis are taken as raw materials, and medically acceptable auxiliary materials are added to prepare tablets. For oral administration, rhubarb contains 3g in the daily preparation, Coptis chinensis contains 2g in the daily preparation, and Scutellaria baicalensis contains 2g in the daily preparation. Take orally, 1-3 times a day, 1-3 tablets each time.

Embodiment 3

[0055] The combined extracts of rhubarb, coptis and scutellaria baicalensis are taken as raw materials, and medically acceptable auxiliary materials are added to prepare tablets. Oral administration, wherein rhubarb contains 12g in the daily preparation, Coptis chinensis contains 6g in the daily preparation, and Scutellaria baicalensis contains 6g in the daily preparation. Take orally, 3 times a day, 1 tablet each time.

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PUM

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Abstract

The invention discloses a traditional Chinese medicinal combined extract and application thereof. Preparation raw materials of the traditional Chinese medicinal combined extract comprise the followingcomponents in parts by weight: 3 to 4 parts of radix et rhizoma rhei, 2 parts of rhizoma coptidis and 2 parts of radix scutellariae, and is prepared through the steps of drying at a low temperature,smashing, adding water for decocting, filtering, carrying out vacuum concentration, spray-drying, then smashing and sieving, and the like. Meanwhile, the invention discloses the application of the traditional Chinese medicinal combined extract to the preparation of a medicine for preventing or treating a vascular disease induced by hypertension; moreover, through establishing a vascular endothelial cell injury model caused by angiotensin II (AngII) and establishing a vascular injury model caused by the AngII and establishing a vascular injury model caused by the AngII in association with deoxycorticosterone acetate, the traditional Chinese medicinal combined extract is proven to have the effects of recovering the function of an endothelial cell, suppressing the expression of NLRP3 (Nod-Like Receptor Protein 3) inflammasome and suppressing the activation of the NLRP3 inflammasome and the effect of restoring intravascular connexin, and further, the drug effect of protecting a blood vessel is shown.

Description

technical field [0001] The present invention relates to the new application of rhubarb, coptis and scutellaria baicalensis combined extracts in the field of medical technology, more specifically, the use of rhubarb, huanglian and scutellaria baicalensis combined extracts for preventing or treating vascular diseases induced by hypertension. Background technique [0002] According to the annual report of "China Cardiovascular Disease Report 2015", there are about 290 million patients with cardiovascular diseases (including coronary heart disease, stroke, heart failure, and hypertension) in China, and they are showing a rapid growth trend. Cardiovascular disease accounted for 44.6% of residents' death in rural areas and 42.52% in urban areas. Cardiovascular disease accounts for more than 40% of the residents' disease deaths, and is the first cause of death among Chinese residents. The development of related therapeutic drugs has made great progress in the past few decades, but...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P9/12A61P9/00
CPCA61K36/539A61K36/708A61K36/718A61K2300/00
Inventor 陈扬连大卫周星张宜吴艳娇蔡东鹏
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE