Gastrin-releasing peptide precursor diluent, and application and kit thereof

A gastrin-releasing peptide and diluent technology, which is applied in biological testing, preparation of test samples, material inspection products, etc., can solve inaccurate detection, thermal stability, unsatisfactory stability of freeze-dried products, and poor thermal stability and other problems, to achieve the effect of good reproducibility, accurate detection results of gastrin releasing peptide precursor, and guaranteed stability

Inactive Publication Date: 2018-07-27
SHENZHEN NEW INDS BIOMEDICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Another object of the present invention is to provide a gastrin-releasing peptide precursor calibrator or quality control product to solve the problem of thermal stability of gastrin-releasing peptide precursor calibrator or quality control product or its lyophilized product after rethawing Technical issues with unsatisfactory stability
[...

Method used

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  • Gastrin-releasing peptide precursor diluent, and application and kit thereof
  • Gastrin-releasing peptide precursor diluent, and application and kit thereof
  • Gastrin-releasing peptide precursor diluent, and application and kit thereof

Examples

Experimental program
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Effect test

Embodiment 11

[0129] This embodiment provides a ProGRP dilution. The ProGRP dilution contains the components at the concentrations in Table 11 below, and the measured pH value is 5.5. It can be formulated as follows:

[0130] Taking 1000mL antigen diluent as an example, the dosage of the components is as follows:

[0131] Solution A: 0.1M citric acid diluent (21.01g)

[0132] Solution B: 0.1M sodium citrate dilution (29.41g)

[0133] Table 11

[0134] Preparation concentration

Embodiment 12

[0136] This embodiment provides a ProGRP dilution. The ProGRP dilution contains the components in the middle concentrations in Table 12 below, and the measured pH value is 4.5. It can be formulated as follows:

[0137] Taking 1000mL antigen diluent as an example, the dosage of the components is as follows:

[0138] Solution A: 0.1M citric acid diluent (21.01g)

[0139] Solution B: 0.1M sodium citrate dilution (29.41g)

[0140] Table 12

[0141] Preparation concentration

Embodiment 13

[0143] This embodiment provides a ProGRP dilution. The ProGRP dilution contains the components in the concentrations shown in Table 13 below, and the measured pH value is 5.5. It can be formulated as follows:

[0144] Taking 1000mL antigen diluent as an example, the dosage of the components is as follows:

[0145] Solution A: 0.1M citric acid diluent (21.01g)

[0146] Solution B: 0.1M sodium citrate dilution (29.41g)

[0147] Table 13

[0148] Preparation concentration

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Abstract

The invention discloses a gastrin-releasing peptide precursor diluent, and an application and a kit thereof. The gastrin-releasing peptide precursor diluents includes: 0.01-0.5 mol/L of one or two buffer solutions including citric acid-sodium citrate and citric acid-disodium hydrophosphate, 50-500 mmol/L of inorganic salt, and 0.01-0.5% w/w of a preservative. The gastrin-releasing peptide precursor diluent is used for preparing a calibrator and a quality control substance of gastrin-releasing peptide precursor. The gastrin-releasing peptide precursor detection kit contains the gastrin-releasing peptide precursor calibrator and quality control substance, which are prepared from the gastrin-releasing peptide precursor diluent; the gastrin-releasing peptide precursor diluent not only ensuresthat a gastrin-releasing peptide precursor antigen can be preserved at 2-8 DEG C for a long time under liquid status, but also significantly increase the thermostability of the gastrin-releasing peptide precursor antigen under liquid-state preservation at 37 DEG C.

Description

technical field [0001] The invention belongs to the technical field of medical reagents, and in particular relates to a gastrin releasing peptide precursor dilution solution, a gastrin releasing peptide precursor calibrator or quality control product and a gastrin releasing peptide precursor detection kit. Background technique [0002] The morbidity and mortality of lung cancer are increasing year by year in the world, seriously endangering human health. Lung cancer is divided into two categories according to histopathological classification: small cell lung cancer (SCLC) and non-small cell lung cancer (non-small cell lung cancer). -small celllung cancer, NSCLC), in which SCLC accounts for about 15%-20% of the total lung cancer population, and has the characteristics of high malignancy, rapid proliferation, and easy distant metastasis. Compared with NSCLC, SCLC is more sensitive to chemotherapy and radiotherapy, and has a higher early survival rate. However, most SCLC patien...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/574G01N1/38
CPCG01N1/38G01N33/57423G01N33/57496G01N33/6893
Inventor 饶微殷俊袁锦云陈庆李婷华李武
Owner SHENZHEN NEW INDS BIOMEDICAL ENG
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