Preparation method of emulsion having whitening and moisturizing effects

A whitening and efficacy technology, applied in the direction of medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve the problems of single whitening mechanism, grainy feeling, and incomplete dissolution of active ingredients, so as to increase the whitening effect , stable emulsion, good emulsification and moisturizing effect

Active Publication Date: 2018-08-03
ZHEJIANG UNIV OF TECH
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AI Technical Summary

Problems solved by technology

[0003] At present, most of the whitening skin care products on the market generally have the problem of a single whitening mechanism: the products only target the formation and transfer mechanism of melanin, from the inhibition of tyrosinase activity, the reduction of already formed melanin and the inhibition of melanin transfer. Step by step to carry out whitening formula design, can not achieve full-effect whitening
The emulsion prepared by this method has a solid core, so it will have a grainy feeling when used, giving people a feeling that the active ingredient has not been completely dissolved

Method used

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  • Preparation method of emulsion having whitening and moisturizing effects

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of seaweed polysaccharide enzymatic hydrolysis product

[0029] 1. Seaweed polysaccharide extraction method: wash the seaweed, control the water, dry it in an oven at 60°C, and crush it. Take 1kg of algae powder, add 2L of 95% ethanol solution to soak and degrease, and let stand overnight. Take the degreased algae powder, add distilled water according to 1kg:10L solid-liquid ratio, and bathe in 95℃ water for 2h. After hot water extraction, cool and stand for 1 hour, then refrigerate and centrifuge for 10 minutes (10000 rpm, 4°C). The supernatant, that is, the crude polysaccharide extract was concentrated to 2 L by rotary evaporation, and 95% ethanol solution was added until the final volume fraction of ethanol was 30%, and stood overnight. The sample solution was refrigerated and centrifuged for 10 minutes (10,000 rpm, temperature 4°C), and the precipitate was taken, and a small amount of distilled water was added to dissolve the precipitate ...

Embodiment 2

[0032] (1) Weigh 20 g of hydrogenated soybean oil (purchased from Wuhan Hezhong Biochemical Manufacturing Co., Ltd.), and heat to 85° C. to obtain liquid oil phase I;

[0033](2) 4g of arbutin (purchased from Xi'an Lutian Biotechnology Co., Ltd.), 6g of ascorbyl glucoside (purchased from Xi'an Wanfang Biotechnology Co., Ltd.), nicotinamide were weighed in a ratio of 4:6:1 by mass (purchased from Henan Datang Chemical Co., Ltd.) 1g, the above-mentioned three kinds of substances are mixed to obtain a composite whitening active substance;

[0034] (3) composite whitening active substance by mass ratio: liquid oil phase I=0.30: 1, take by weighing composite whitening active substance 6g and add in the liquid oil phase I of step (1) gained, mix homogeneously, obtain liquid oil phase II;

[0035] (4) weigh 30g of seaweed polysaccharide enzymolysis product, 15g of phospholipids and 150g of distilled water in a ratio of 0.2:0.1:1 by mass, heat to 75-85°C, and mix to obtain a liquid wa...

Embodiment 3

[0038] (1) 15 g of hydrogenated soybean oil (purchased from Wuhan Hezhong Biochemical Manufacturing Co., Ltd.) was weighed, heated to 85° C. to obtain liquid oil phase I;

[0039] (2) 1 g of arbutin (purchased from Xi'an Lvtian Biotechnology Co., Ltd.), 1.5 g of ascorbyl glucoside (purchased from Xi'an Wanfang Biotechnology Co., Ltd.), Amide (purchased from Henan Datang Chemical Co., Ltd.) 0.5g, the above three substances were mixed to obtain a composite whitening active substance;

[0040] (3) by mass ratio composite whitening active substance: liquid oil phase I=0.15: 1 take by weighing composite whitening active substance 2.25g and add in the liquid oil phase I of step (1) gained, mix homogeneously, obtain liquid oil phase II;

[0041] (4) weigh 12g of seaweed polysaccharide enzymolysis product, 7.5g of phospholipid and 150g of distilled water in a ratio of 0.08:0.05:1 by mass, heat to 75~85°C, and mix to obtain a liquid water phase;

[0042] (5) weigh 15 g of liquid oil p...

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Abstract

The invention provides a preparation method of emulsion having whitening and moisturizing effects. The preparation method comprises the following steps: (1) weighing hydrogenated soybean oil, and heating to 75 to 85 DEG C, thus obtaining a liquid-state oil phase I; (2) weighing arbutin, ascorbyl glucoside and nicotinamide in proportion, and mixing the three substances, thus obtaining a composite whitening active substance; (3) adding the composite whitening active substance into the liquid-state oil phase I in proportion, and uniformly mixing, thus obtaining a liquid-state oil phase II; (4) weighing algal polysaccharide enzymatic hydrolysate, phospholipid and distilled water in proportion, heating to 75 to 85 DEG C, and uniformly mixing, thus obtaining a liquid-state water phase; (5) weighing the liquid-state oil phase II, the liquid-state water phase and tea polyphenol in proportion, and uniformly mixing and stirring, thus obtaining a mixed solution; carrying out high-pressure homogenization on the mixed solution, thus obtaining nano-emulsion; cooling the obtained nano-emulsion to room temperature, and adding an appropriate amount of a preservative, thus obtaining the emulsion having the whitening and moisturizing effects. The emulsion prepared by the invention has the whitening and moisturizing effects and has good stability.

Description

(1) Technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a preparation method of an emulsion with whitening and moisturizing effects. (2) Technical background [0002] Whitening has always been paid close attention to by people, and whitening skin care products have also been highly praised and pursued by women. The skin color difference of the human body usually depends on factors such as the content and distribution of melanin in the epidermis, the collagen fiber structure of the dermis, and the thickness and water content of the stratum corneum. [0003] At present, most of the whitening skin care products on the market generally have the problem of a single whitening mechanism: the products only target the formation and transfer mechanism of melanin, from the inhibition of tyrosinase activity, the reduction of already formed melanin and the inhibition of melanin transfer. The whitening formula design is carried o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/92A61K8/73A61K8/67A61K8/60A61K8/55A61K8/49A61K8/06A61Q19/00A61Q19/02
CPCA61K8/06A61K8/498A61K8/553A61K8/602A61K8/675A61K8/676A61K8/73A61K8/922A61K8/9789A61K2800/782A61Q19/00A61Q19/02
Inventor 邵平牛犇蒋丽刚
Owner ZHEJIANG UNIV OF TECH
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