Method for preparing dexamethasone magnetic microsphere

A technology of dexamethasone and magnetic microspheres, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as ineffective treatment

Active Publication Date: 2018-08-10
GENERAL HOSPITAL OF PLA
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Problems solved by technology

[0009] In order to overcome the existing technology in the process of treating chronic soft tissue pain that brings more adverse reactions to patients and cannot effectively treat the deficiency, the present invention provides a preparation method of dexamethasone magneti

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  • Method for preparing dexamethasone magnetic microsphere
  • Method for preparing dexamethasone magnetic microsphere
  • Method for preparing dexamethasone magnetic microsphere

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Embodiment Construction

[0030] The present invention will be further described below in conjunction with accompanying drawing:

[0031] 1. Preparation of dexamethasone magnetic microspheres:

[0032] The microspheres are made by S / O / W method. According to PLGA / Fe 3 o 4 It is the ratio of 4:1, according to the feeding ratio of 1:3,1:4,1:5 [feeding ratio=(dexamethasone quality):(dexamethasone quality+PLGA quality+Fe 3 o 4 Nano-powder)], after calculating the specific mass, weigh respectively, put the weighed PLGA into 3ml dichloromethane (O), and oscillate for 10min at 3000r / min with an intermittent vortex oscillator until completely dissolved; The weighed Fe 3 o 4 Dissolve the nano-powder in the above solution, and after ultrasonic vibration for 1 min to mix, then dissolve 100 mg of dexamethasone powder (S) in dichloromethane, ultrasonic vibration until completely dissolved, and use a homogeneous stirrer at 10000r / min, then, The above dichloromethane mixed solution was slowly dropped into 30ml ...

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Abstract

The invention provides a method for preparing a dexamethasone magnetic microsphere, and belongs to the technical field of dexamethasone application. The method comprises the steps that PLGA serves ascarrier shell, dexamethasone serves as a drug core, ferroferric oxide nanopowder serves as a magnetic core, dichloromethane serves as an organic phase, polyvinyl alcohol (polyvinyl alcohol, PVA) serves as an aqueous phase, and the dexamethasone magnetic microsphere is prepared by an emulsification-solvent evaporation method (S/O/W). In clinical application, the dexamethasone magnetic microsphere is injected into an affected part, a dynamic magnetic field is applied in vitro, the dexamethasone is gradually released to play an antiphlogistic role, the magnetic microsphere vibrates under the action of the external dynamic magnetic field to improve local circulation, thereby promoting inflammatory product absorption, in addition, the local dexamethasone magnetic microsphere can play a role ofphysical therapy, and through the above principle, the treatment of chronic soft tissue pain can be achieved.

Description

technical field [0001] The invention belongs to the technical field of dexamethasone application, and in particular relates to a preparation method of dexamethasone magnetic microspheres. Background technique [0002] Dexamethasone, also known as dexamethasone, flumethasone, dexamethasone, is a glucocorticoid. Its derivatives include hydrocortisone, prednisone, etc., and its pharmacological effects are mainly anti-inflammatory, anti-toxic, anti-allergic, and anti-rheumatic, and are widely used clinically. It is easily absorbed from the digestive tract, its plasma T1 / 2 is 190 minutes, and its tissue T1 / 2 is 3 days. After intramuscular injection of dexamethasone sodium phosphate or dexamethasone acetate, the peak plasma concentration is reached in 1 hour and 8 hours respectively . The plasma protein binding rate of this product is lower than that of other corticosteroids, and the anti-inflammatory activity of 0.75 mg of this product is equivalent to 5 mg of prednisolone. Ad...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/34A61K9/16A61K31/573A61P29/00
CPCA61K9/1641A61K31/573A61K41/0052A61K47/34A61P29/00
Inventor 孙永海孙畅金鑫
Owner GENERAL HOSPITAL OF PLA
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