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Benzopyrone dipolymer and extracting method and application thereof

A technology of benzopyrone dimer and extraction method, which is applied in the field of benzopyrone dimer preparation and achieves the effects of good cytotoxic activity and good antitumor activity

Active Publication Date: 2018-08-10
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on benzopyrone dimer and its activity in endophytic fungi from cat feces

Method used

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  • Benzopyrone dipolymer and extracting method and application thereof
  • Benzopyrone dipolymer and extracting method and application thereof
  • Benzopyrone dipolymer and extracting method and application thereof

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Embodiment Construction

[0035] Embodiments of the present invention are described in further detail below:

[0036] A benzopyrone dimer compound, the chemical structural formula of the compound:

[0037]

[0038] The extraction method of this compound is as follows:

[0039] (1) Carry out strain culture to cat feces endophyte Aspergillus tubingensis (Aspergillus tubingensis) DS37 in strain culture medium;

[0040] (2) In the fermentation medium, the bacterial classification obtained in step (1) is fermented and cultivated, and the fermentation product (9.2kg) is used as raw material to extract 8 times with petroleum ether / ethyl acetate / methanol, and the combined extracts are filtered , reclaim mixed solvent, concentrate under reduced pressure, obtain crude product extract 1500g;

[0041] (3) Put the crude product extract obtained in step (2) on a silica gel chromatographic column, and use petroleum ether with a volume gradient of 1:0:0, 0:1:0, 0:1:1, and 0:0:1 respectively / Ethyl acetate / methan...

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Abstract

The invention discloses a benzopyrone dipolymer and an extracting method and an application of the benzopyrone dipolymer. The extracting method comprises the following steps: (1) culturing a strain ofmedium endophytic fungi aspergillus tubingensis DS37 of decaisnea insignis in a strain culture; (2) fermenting and culturing the strain obtained in the step (1) in a fermenting and culturing medium,extracting with petroleum ether, ethyl acetate and methyl alcohol for a plurality of times, mixing extracting solutions, filtering, recovering a mixed solvent, implementing vacuum concentration on a filtrate to obtain a coarse product of an extractum, and finally conducting column chromatography on silica gel to obtain the benzopyrone dipolymer. The prepared benzopyrone dipolymer has an excellenteffect on inhibiting staphylococcus aureus, and can be used in the technique of chemical control; the benzopyrone dipolymer is relatively strong in anti-A549 cell strain activity and provides a possibility for the development of the antitumor drug; and meanwhile, the benzopyrone dipolymer has a certain antioxidant activity.

Description

technical field [0001] The invention relates to the field of preparation of benzopyrone dimers, in particular to a benzopyrone dimer and its extraction method and application. Background technique [0002] Decaisnea insignis (Griff.) Hook.f. & Thomson) is a plant of the genus Decaisnea insignis (Lardiyabalaeeae). Clumping deciduous erect shrubs, widely distributed in southwestern and central China. Akebia plant cat's feces is a traditional folk Chinese herbal medicine in my country. It tastes pungent, sweet, and flat in nature. The root and fruit are sweet and cool. So far, research on cat feces has mainly focused on its phytochemical components, while relatively little research has been done on its endophytic fungi. According to reports, the main types of secondary metabolites of endophytic fungi include: alkaloids, terpenes, steroids, organic acids and other compounds, all of which have certain biological activities. However, there is no report about benzopyrone dimer a...

Claims

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Application Information

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IPC IPC(8): C07D311/92A61P31/04A61P31/10A61P35/00A61P39/06C12P17/16C12R1/66
CPCA61P31/04A61P31/10A61P35/00A61P39/06C07D311/92C12P17/162
Inventor 杨秀芳王宁宁马养民陈镝雒佳欣胡岩杨恒汪小钢
Owner SHAANXI UNIV OF SCI & TECH
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