Novel candida-killing polypeptide CFP1 and preparation method thereof

A new type of technology for Candida, which is applied in the field of new Candida-killing polypeptides and its preparation, and can solve the problems of unstable expression products, low product yields, and difficult purification
CN108409833AActive Publication Date: 2018-08-17HENAN UNIVERSITY OF TECHNOLOGY
1 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HENAN UNIVERSITY OF TECHNOLOGY
Publication Date
2018-08-17

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a candida-killing polypeptide sequence and a preparation method. An amino acid sequence of the candida-killing polypeptide is NH2-RILSILRHQ-COOH. A solid-phase polypeptide synthesis method is adopted for preparation. Defects of proneness to hemolysis and poor biological safety of common antibacterial peptides are overcome. The polypeptide is a novel antifungal polypeptide with a specific candida killing effect and without hemolysis and provides a novel primer for clinical antifungal drug research.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to biological preparations, and in particular relates to a novel candida-killing polypeptide and a preparation method thereof. Background technique

[0002] Worldwide, as the number of immunocompromised patients increases, the incidence of fungal infections increases, and many clinical diseases caused by Candida spp are associated with significant mortality and morbidity in medical institutions. Studies have shown that among the invasive fungal infections, Candida infection is the main one. Due to the abuse of antibiotics, drug-resistant pathogenic Candida is increasing. Therefore, it is of great significance to research and develop new antifungal drugs with high efficiency, low toxicity and resistance to pathogenic fungi as soon as possible.

[0003] Existing studies have shown that antimicrobial peptides (AMP) are considered as lead compounds in the development of new antibacterial drugs (LvY, et al.PLoS ONE, 2014, 9:e86364). ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More