Nano supermolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA as well as preparation method and application

A technology of cyclodextrin and calixarene, applied in the field of nano-supramolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA and its preparation

Inactive Publication Date: 2018-08-24
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, no one has used different types of amphiphilic macrocyclic molecules to co-assemble to construct a supramolecular system for selective recognition of proteins

Method used

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  • Nano supermolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA as well as preparation method and application
  • Nano supermolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA as well as preparation method and application
  • Nano supermolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA as well as preparation method and application

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Embodiment 1

[0025] A nanosupramolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA, the chemical formula of CD of the building unit is C 182 h 350 o 56 S 7 , the chemical formula of CA is C 100 h 150 o 15 , the supramolecular assembly is constructed through weak π–π interactions and hydrophobic interactions, and its morphology scale is nanoscale, spherical vesicles. Its structural formula is as follows:

[0026]

[0027] A method for preparing the amphiphilic cyclodextrin CD and the amphiphilic calixarene CA nano-supramolecular co-assembly, the steps are as follows:

[0028] Dissolve CD and CA in chloroform, respectively, and prepare a mother solution of 1 mmol / ml. During preparation, take 300 microliters of CD and 300 microliters of CA chloroform solution from 1 millimolar per milliliter of mother liquor, mix thoroughly, place on a rotary evaporator, set the temperature at 40°C, and slowly rotate until the chloroform is completely volatilized So fa...

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Abstract

The invention discloses a nano supermolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA as well as a preparation method and an application and belongs to the technical field of nano supermolecular materials. Amphiphilic beta cyclodextrin CD and amphiphilic carboxyl calyx[5]arene CA are used as construction units and can form co-assembly vesicles in a certain manner under the condition of coexistence in a water liquor, by means of the method, cavities of cyclodextrin and calyxarene are enriched in surfaces of the vesicles, multi-valence bonding with polypeptide can be formed on vesicle interfaces by use of the selective recognition capacity of the cavities and amino acid, and selective recognition of polypeptide can be realized, so that protein is recognized.

Description

technical field [0001] The invention belongs to the technical field of nano-supramolecular materials, in particular to a nano-supramolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA and its preparation method and application. Background technique [0002] Proteins play a very important role in the life activities of cells and organisms. Many proteins are disease markers and therapeutic targets. How to effectively identify proteins has always been a major problem. Solving the problem of protein interface recognition will not only provide impetus for the development of proteomics, but also bring new dawn for the treatment of diseases. See: 1) S. Dutt, C. Wilch, T. Schrader, Chem. Commun. 2011, 47, 5376-5383; 2) T. Schrader, S. Koch, Mol. BioSyst. 2007, 3, 241-248; 3) R. Ludwig, Microchim. Acta 2005, 152, 1-19. [0003] In the past, the more commonly used means of identifying and separating proteins was physical adsorption, but the method of ph...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61K47/69A61K47/40A61K47/32A61K9/127C07K1/14
CPCA61K9/1273A61K47/32A61K47/40A61K47/6951C07K1/14C08G83/008
Inventor 郭东升徐喆彭姝
Owner NANKAI UNIV
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