Nanosupramolecular co-assembly of amphiphilic cyclodextrin cd and amphiphilic calixarene ca and its preparation method and application

A technology of co-assembly and cyclodextrin, which is applied to the preparation method of peptides, chemical instruments and methods, non-active ingredients of polymer compounds, etc.

Inactive Publication Date: 2021-02-05
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, no one has used different types of amphiphilic macrocyclic molecules to co-assemble to construct a supramolecular system for selective recognition of proteins

Method used

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  • Nanosupramolecular co-assembly of amphiphilic cyclodextrin cd and amphiphilic calixarene ca and its preparation method and application
  • Nanosupramolecular co-assembly of amphiphilic cyclodextrin cd and amphiphilic calixarene ca and its preparation method and application
  • Nanosupramolecular co-assembly of amphiphilic cyclodextrin cd and amphiphilic calixarene ca and its preparation method and application

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Embodiment 1

[0025] A nanosupramolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA, the chemical formula of CD of the building unit is C 182 h 350 o 56 S 7 , the chemical formula of CA is C 100 h 150 o 15 , the supramolecular assembly is constructed through weak π–π interactions and hydrophobic interactions, and its morphology scale is nanoscale, spherical vesicles. Its structural formula is as follows:

[0026]

[0027] A method for preparing the amphiphilic cyclodextrin CD and the amphiphilic calixarene CA nano-supramolecular co-assembly, the steps are as follows:

[0028] Dissolve CD and CA in chloroform, respectively, and prepare a mother solution of 1 mmol / ml. During preparation, take 300 microliters of CD and 300 microliters of CA chloroform solution from 1 millimolar per milliliter of mother liquor, mix thoroughly, place on a rotary evaporator, set the temperature at 40°C, and slowly rotate until the chloroform is completely volatilized So fa...

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Abstract

The invention discloses a nano-supramolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA, a preparation method and application thereof, and belongs to the technical field of nano-supramolecular materials. In the present invention, amphiphilic β-cyclodextrin CD and amphiphilic carboxycalix [5]arene CA are used as construction units to form co-assembled vesicles in a certain way under the condition of coexistence in aqueous solution. The surface of the surface is enriched with cyclodextrin and calixarene cavities, and the ability of selective recognition of cavities and amino acids can be used to form multivalent bonds with polypeptides on the vesicle interface to achieve selective recognition of polypeptides, and then Identify the protein.

Description

technical field [0001] The invention belongs to the technical field of nano-supramolecular materials, in particular to a nano-supramolecular co-assembly of amphiphilic cyclodextrin CD and amphiphilic calixarene CA and its preparation method and application. Background technique [0002] Proteins play a very important role in the life activities of cells and organisms. Many proteins are disease markers and therapeutic targets. How to effectively identify proteins has always been a major problem. Solving the problem of protein interface recognition will not only provide impetus for the development of proteomics, but also bring new dawn for the treatment of diseases. See: 1) S. Dutt, C. Wilch, T. Schrader, Chem. Commun. 2011, 47, 5376-5383; 2) T. Schrader, S. Koch, Mol. BioSyst. 2007, 3, 241-248; 3) R. Ludwig, Microchim. Acta 2005, 152, 1-19. [0003] In the past, the more commonly used means of identifying and separating proteins was physical adsorption, but the method of ph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00A61K47/69A61K47/40A61K47/32A61K9/127C07K1/14
CPCA61K9/1273A61K47/32A61K47/40A61K47/6951C07K1/14C08G83/008
Inventor 郭东升徐喆彭姝
Owner NANKAI UNIV
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