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Application of 1-MNA (Methylnicotinamide) in preparing drug for preventing or treating alcoholic fatty liver

A technology for alcoholic fatty liver disease and methyl nicotinamide, which is applied in drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as the lack of safe and effective treatment for ALD, and achieve the effect of restoring liver damage and reducing accumulation.

Inactive Publication Date: 2018-09-04
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, ALD has become a public health problem of global concern, but so far there is no safe and effective clinical drug for the treatment of ALD.

Method used

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  • Application of 1-MNA (Methylnicotinamide) in preparing drug for preventing or treating alcoholic fatty liver
  • Application of 1-MNA (Methylnicotinamide) in preparing drug for preventing or treating alcoholic fatty liver
  • Application of 1-MNA (Methylnicotinamide) in preparing drug for preventing or treating alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Materials:

[0023] Experimental animals: 30 C57BL / 6 male mice, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., company license number: SCXX (Beijing) 2007-0001, kept in the Experimental Animal Center of Zhejiang University of Traditional Chinese Medicine, SPF environment middle.

[0024] Reagent: 1-methylnicotinamide chloride (1-MNA), Chinese name: 1-methylnicotinamide chloride; Lieber-DeCarli alcohol liquid model feed (product code TP-4030B, Nantong Trophy Feed Technology Co., Ltd.); Lieber - DeCarli control liquid feed (product code TP-4030BC, Nantong Trofe Feed Technology Co., Ltd.); choline, vitamins (Nantong Trofe Feed Technology Co., Ltd.). Absolute ethanol (CAS-NO: 64-17-5, lichrosolv), triglyceride kit (lot number: F005-2, Nanjing Jiancheng Bioengineering Institute)

[0025] 2. Method:

[0026] After the C57BL / 6 mice were fed for one week in the SPF level animal laboratory, the 8-week-old C57BL / 6 mice were randomly divided i...

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Abstract

The invention discloses application of 1-MNA (Methylnicotinamide) in preparing a drug for preventing or treating alcoholic fatty liver. Accumulation of liver triglyceride caused by alcohol model dietis reduced by the 1-MNA. Liver injury caused by the alcohol model diet is recovered by the 1-MNA.

Description

(1) Technical field [0001] The invention relates to a new application of 1-MNA (1-methylnicotinamide), that is, the application of 1-MNA in the preparation of drugs for preventing or treating alcoholic fatty liver. (2) Background technology [0002] Alcoholic Liver Disease (ALD) is a fatty liver disease caused by long-term heavy drinking, which can further develop into more serious alcoholic hepatitis, liver fibrosis, liver cirrhosis and even primary liver cancer. Alcoholic cirrhosis accounted for 50 percent of all cirrhotic deaths as of 2010, the study noted. The American ALD guidelines pointed out that 44% of the deaths from liver cirrhosis in the American population were related to alcohol abuse. In recent years, the intake of alcohol among Chinese people has been increasing. By 2013, the amount of alcohol consumed in my country was second only to European and American countries, ranking second in the world; the incidence of ALD increased from 2.27% in 2000 to 8.74% in ...

Claims

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Application Information

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IPC IPC(8): A61K31/4425A61P1/16A61P3/06
CPCA61K31/4425A61P1/16A61P3/06
Inventor 窦晓兵李松涛丁秦超马月宋振远
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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