Bi-crosslinking mussel binding protein bionic hydrogel for tissue adhesive and preparation method of bi-crosslinking mussel binding protein bionic hydrogel

Abstract

The invention relates to a bi-crosslinking mussel binding protein bionic hydrogel for a tissue adhesive and a preparation method of the bi-crosslinking mussel binding protein bionic hydrogel. The hydrogel is obtained by taking mercapto group modified chitosan containing dopa residues as a matrix and performing bi-crosslinking under the condition of four-arm polyethyleneglycol succinimidyl carbonate and sodium periodate. The preparation method comprises the following steps of preparation of dopa residue modified chitosan, preparation of dopa residue and mercapto group modified chitosan, preparation of four-arm polyethyleneglycol succinimidyl carbonate and preparation of the bi-crosslinking mussel binding protein bionic hydrogel. In the preparation method provided by the invention, by takingthe sodium periodate as a crosslinking agent which performs rapid crosslinking and the four-arm polyethyleneglycol succinimidyl carbonate as a crosslinking agent which is relatively slow in reaction,the hydrogel is prepared by bi-crosslinking, the crosslinking speed is rapid, and the prepared hydrogel has very good adhesion performance, biocompatibility and mechanical strength and is hydrogel which can be used for the tissue adhesive.

Description

technical field [0001] The invention belongs to the field of hydrogel and its preparation, in particular to a double-crosslinked mussel binding protein biomimetic hydrogel used for tissue adhesives and a preparation method thereof. Background technique [0002] Traditional mechanical wound closure devices, such as paper clips, rivets, and surgical sutures, often cause damage to the tissues around the wound, and are not suitable for organs such as the liver, spleen, and kidney with low cohesive strength, and these wound closure devices The operation in the body is complicated and requires certain skills, and a second operation is required to remove it. However, tissue adhesives can effectively solve or avoid these problems. When tissue adhesives restore the function of damaged parts, they can also restore their appearance before the damage. They have good biodegradability and do not require secondary This operation greatly reduces the pain of patients and the workload of doc...

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Problems solved by technology

However, these hydrogels tend to swell or dissolve quickly, or have low cohesive or mechanical strength, thus reducing their effectiveness as clinical surgical procedures.

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