A kind of preparation method of potassium aspartate crystal

A technology of potassium aspartate and aspartic acid, applied in the field of preparation of potassium aspartate crystals, can solve the problems of large water consumption and the like

Active Publication Date: 2020-09-18
ANHUI HEALSTAR PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a method for preparing potassium aspartate crystals, which solves the problem that the traditional method for preparing potassium aspartate consumes a large amount of water

Method used

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  • A kind of preparation method of potassium aspartate crystal
  • A kind of preparation method of potassium aspartate crystal
  • A kind of preparation method of potassium aspartate crystal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] At 20-25°C, add 40ml of pure water to a 2L three-necked reaction flask, turn on the mechanical stirring, add 133.0g of aspartic acid, turn on the heating to an internal temperature of 50-60°C, add 69.0g of potassium carbonate in batches, and wait for the reaction to be clarified Finally, keep stirring at 50-60°C for 1-2 hours, measure the pH value of 5.8-6.0, adjust the pH value to 6.5-6.8 with 1-2% (potassium carbonate weight percentage) of potassium carbonate; cool down to 40-50°C and add medicinal Activated carbon was stirred for 1-2 hours to filter, the filtrate was cooled to 15-25°C, 1130ml of isopropanol was added to the reaction solution, and the internal temperature was kept at -5-20°C to crystallize for 8-12 hours, suction filtered, and the filter cake was placed at 45 °C in a vacuum oven for 9 hours, collected the material, and obtained an off-white amorphous potassium aspartate hemihydrate product with a yield of 96.2%.

Embodiment 2

[0033] At 20-25°C, add 80ml of pure water to a 5L three-necked reaction flask, turn on the mechanical stirring, add 266.2g of aspartic acid, turn on the heating to an internal temperature of 50-60°C, add 138.2g of potassium carbonate in batches, and wait for the reaction to be clarified Finally, keep stirring at 50-60°C for 1-2 hours, measure the pH value of 5.8-6.0, adjust the pH value to 6.5-6.8 with 1-2% (potassium carbonate weight percentage) of potassium carbonate, cool down to 40-50°C and add medicinal Activated carbon was stirred for 1-2 hours to filter, the filtrate was cooled to 15-25°C, 2260ml of isopropanol was added to the reaction solution, and the internal temperature was kept at -5-20°C to crystallize for 8-12 hours, suction filtered, and the filter cake was placed at 45 °C in a vacuum oven for 9 hours, collected the material, and obtained an off-white amorphous potassium aspartate hemihydrate product with a yield of 96.5%.

[0034] Perform XRD diffraction and T...

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Abstract

The invention discloses a preparation method of potassium aspartate crystals. The method comprises the following steps of (1) adding pure water being 0.25 times the mass of aspartic acid into a reaction container; in the stirring state, adding the aspartic acid and potassium carbonate; preparing a potassium aspartate aqueous solution; (2) after reaction clarification, regulating the pH value to 6.5 to 6.8 by potassium carbonate; (3) adding medical active carbon into the obtained solution for decoloration filtering; (4) adding organic solvents into filter liquid; (5) controlling the crystal separation temperature at 0 to 20 DEG C; performing cooling crystal separation for separating the crystals for 8 to 12 hours; performing vacuum drying on filter cake to obtain a product. The 0.25 times of pure water (relative to the mass of the aspartic acid) is used as the reaction solvents; the discharge of a great amount of waste water is reduced; then, the energy consumption is reduced by controlling the crystallization temperature; the solvents such as isopropanol, n-butyl alcohol and methylisobutylketone are reasonably used for obtaining a potassium aspartate finished product capable of being more stably stored; the operation in the whole crystal preparation process is simple; the cost and the energy consumption are low; the product can be easily stored; the method is very suitable forindustrialized production.

Description

technical field [0001] The invention relates to a method for preparing crystals, in particular to a method for preparing potassium aspartate crystals. Background technique [0002] The molecular formula of potassium aspartate is C 4 h 6 KNO 4 1 / 2H 2 O, the molecular weight is 180.20, and the molecular structure formula is [0003] [0004] Potassium aspartate is an electrolyte replenishing drug. Potassium is the main cation in cells, and its concentration is 150-160mmol / L. The body mainly relies on Na+-K+ATPase on the cell membrane to maintain K inside and outside the cell. + 、Na + Concentration difference. The acid-base balance in the body has an impact on potassium metabolism, such as H in acidosis + Into the cell, in order to maintain the potential difference between the inside and outside of the cell, K + Released out of cells, causing or aggravating hyperkalemia. Metabolic disorders can also cause acid-base balance. Normal intracellular and intracellular po...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/24C07C227/18C07C227/42
CPCC07C227/18C07C227/42C07C229/24
Inventor 焦英陆
Owner ANHUI HEALSTAR PHARM CO LTD
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