A kind of preparation method of potassium aspartate crystal

Abstract

The invention discloses a preparation method of potassium aspartate crystals. The method comprises the following steps of (1) adding pure water being 0.25 times the mass of aspartic acid into a reaction container; in the stirring state, adding the aspartic acid and potassium carbonate; preparing a potassium aspartate aqueous solution; (2) after reaction clarification, regulating the pH value to 6.5 to 6.8 by potassium carbonate; (3) adding medical active carbon into the obtained solution for decoloration filtering; (4) adding organic solvents into filter liquid; (5) controlling the crystal separation temperature at 0 to 20 DEG C; performing cooling crystal separation for separating the crystals for 8 to 12 hours; performing vacuum drying on filter cake to obtain a product. The 0.25 times of pure water (relative to the mass of the aspartic acid) is used as the reaction solvents; the discharge of a great amount of waste water is reduced; then, the energy consumption is reduced by controlling the crystallization temperature; the solvents such as isopropanol, n-butyl alcohol and methylisobutylketone are reasonably used for obtaining a potassium aspartate finished product capable of being more stably stored; the operation in the whole crystal preparation process is simple; the cost and the energy consumption are low; the product can be easily stored; the method is very suitable forindustrialized production.

Description

technical field [0001] The invention relates to a method for preparing crystals, in particular to a method for preparing potassium aspartate crystals. Background technique [0002] The molecular formula of potassium aspartate is C 4 h 6 KNO 4 1 / 2H 2 O, the molecular weight is 180.20, and the molecular structure formula is [0003] [0004] Potassium aspartate is an electrolyte replenishing drug. Potassium is the main cation in cells, and its concentration is 150-160mmol / L. The body mainly relies on Na+-K+ATPase on the cell membrane to maintain K inside and outside the cell. + 、Na + Concentration difference. The acid-base balance in the body has an impact on potassium metabolism, such as H in acidosis + Into the cell, in order to maintain the potential difference between the inside and outside of the cell, K + Released out of cells, causing or aggravating hyperkalemia. Metabolic disorders can also cause acid-base balance. Normal intracellular and intracellular po...

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Problems solved by technology

[0009] The purpose of the present invention is to provide a method for preparing potassium aspartate crystals, which solves the problem that the traditional method for preparing potassium aspartate consumes a large amount of water

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