The invention discloses a production technology of plasterboard modified starch, comprising the following steps of mixing, degeneration reaction, neutralization reaction, physical synergism, screening, weighing and packaging. The invention combines the advantages of various modified starches, has the advantages of strong size film strength, transparency, good water absorption, good dispersion, good gliding property, low gelatinization temperature, strong paste liquid bond force, good adsorbability, easy dissolution, good film forming ability, weak retrogradation, good elasticity, smoothness, flexibility, tough and elastic size film, nontoxicity, tastelessness, safe use, convenient operation, large production scale, little investment, low energy consumption, less pollution, high productionefficiency, stable and reliable product quality and the like and is widely applied to gypsum products.