A kind of preparation method of salinomycin granule

The technology of salinomycin and granules is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve problems such as increased production cost, waste of resources, etc., and achieves low cost and energy consumption, The effect of high production efficiency and high granulation rate

Active Publication Date: 2021-04-02
PUCHENG CHIA TAI BIOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of the above-mentioned salinomycin granules, 30-40% of the salinomycin fine powder will be produced during the wet powder filter cake crushing, feeding, drying, discharging and sieving into finished products, resulting in a waste of resources. Production costs have also increased significantly

Method used

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  • A kind of preparation method of salinomycin granule
  • A kind of preparation method of salinomycin granule

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preparation example Construction

[0022] The invention provides a preparation method of salinomycin granules, comprising the following steps:

[0023] Mixing the fine powder of salinomycin with water and performing the first wetting treatment to obtain wet powder;

[0024] Mixing the wet powder and binder to obtain a wet product;

[0025] Mixing the wet product with water, performing the second wetting treatment, and then granulating to obtain wet granules;

[0026] The wet granules were dried to obtain salinomycin granules.

[0027] In the present invention, the salinomycin fine powder and water are mixed for the first wetting treatment to obtain the wet powder. In the present invention, the source of the salinomycin fine powder is preferably the fine powder sieved during the production process of salinomycin. In the present invention, the first wetting pretreatment is preferably carried out under stirring conditions, and the stirring speed is preferably 20-30 rpm, more preferably 23-28 rpm; the stirring t...

Embodiment 1

[0037] (1) 1000kg of salinomycin powder and water are placed in a coulter mixer, stirred for 15 minutes at 25 rpm, and the first wetting treatment is carried out to obtain a wet powder with a moisture content of 16.7%;

[0038] (2) Dissolve 10kg of dextrin in 100kg of water to obtain an aqueous solution of dextrin, mix the wet powder, 25kg of sodium lignosulfonate and 25kg of calcium lignosulfonate, add the aqueous solution of dextrin, and stir at 25rpm for 50min for mixing , get the wet product;

[0039] (3) The wet product and water are placed in a mixer and mixed with water for the second wet treatment to obtain a granulated material with a moisture content of 45%, and the obtained granulated material is added to a rotary granulator for granulation to obtain wet grain;

[0040] (4) Send the wet granules into a fluidized dryer via a conveyor belt for drying for 45 minutes, wherein the temperature parameters of the fluidized dryer are as follows: the inlet air temperature is...

Embodiment 2

[0042] (1) 1000kg of salinomycin powder and water are placed in a coulter mixer, stirred at 25rpm for 10min, and the first wetting treatment is carried out to obtain a wet powder with a moisture content of 20%;

[0043] (2) Dissolve 10kg of dextrin in 100kg of water to obtain an aqueous solution of dextrin, mix the wet powder, 30kg of sodium lignosulfonate and 25kg of calcium lignosulfonate, add the aqueous solution of dextrin, and stir at 25rpm for 50min for mixing , get the wet product;

[0044] (3) The wet product and water are placed in a mixer and mixed with water for the second wet treatment to obtain a granulated material with a moisture content of 45%, and the obtained granulated material is added to a rotary granulator for granulation to obtain wet grain;

[0045] (4) Send the wet granules into a fluidized dryer via a conveyor belt for drying for 45 minutes, wherein the temperature parameters of the fluidized dryer are as follows: the inlet air temperature is 110-120°C...

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Abstract

The invention provides a preparation method of salinomycin sodium granules, and belongs to the technical field of the production of antibiotics for livestock. The preparation method of salinomycin sodium granules provided by the invention comprises the following steps of mixing salinomycin sodium fine powder with water, and performing first wetting treatment so as to obtain wet powder; mixing thewet powder with an adhesive so as to obtain wet products; mixing the wet products with water, performing second wetting treatment, and performing granulation so as to obtain wet granules; and drying the obtained wet granules so as to obtain the salinomycin sodium granules. According to the preparation method provided by the invention, the granulation rate of the salinomycin sodium fine powder is high, the granules are good in uniformity, the preparation method provided by the invention is low in repeated granulation frequency, high in production efficiency, simple in technology and low in costand energy consumption, and clean production can be realized.

Description

technical field [0001] The invention relates to the technical field of veterinary antibiotic production, in particular to a preparation method of salinomycin granules. Background technique [0002] Salinomycin is a monocarboxylic acid polyether animal-specific antibiotic, which has a strong inhibitory and killing effect on most Gram-positive bacteria and various coccidia. Because it is not easy to produce drug resistance and cross-resistance, it is excreted quickly and the residue is extremely low, so it is favored. [0003] The production of hydrochloric acid granules is to first make the fermentation filtrate into calcium salt, then filter the plate and frame, then crush the wet powder filter cake and then granulate, dry the obtained granules to obtain semi-finished products, and finally sieve to obtain salinomycin Granular finished product. However, in the preparation process of the above-mentioned salinomycin granules, 30-40% of the salinomycin fine powder will be prod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/351A61K47/36A61K47/40A61P31/04
CPCA61K9/1652A61K9/1694A61K31/351A61P31/04
Inventor 徐汉斌吴贵铨
Owner PUCHENG CHIA TAI BIOCHEM
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