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Application of flufenamic acid in treating spinal cord injury

A technology of flufenamic acid and spinal cord injury, applied in the field of flufenamic acid in the treatment of spinal cord injury, traditional analgesic flufenamic acid, can solve the drug use and research of flufenamic acid for spinal cord injury that have not been reported. and other problems to achieve the effect of improving the repair level and reducing the secondary damage

Inactive Publication Date: 2018-09-28
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0006] So far, no report has proposed the use and research of flufenamic acid in the preparation of drugs for the treatment of spinal cord injuries

Method used

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  • Application of flufenamic acid in treating spinal cord injury
  • Application of flufenamic acid in treating spinal cord injury
  • Application of flufenamic acid in treating spinal cord injury

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Embodiment Construction

[0024] The following description serves to disclose the invention to enable those skilled in the art to practice the invention. The preferred embodiments described below are given by way of example only, and other obvious modifications will occur to those skilled in the art. The basic principles of the present invention defined in the following description can be applied to other embodiments, variations, improvements, equivalents and other technical solutions without departing from the spirit and scope of the present invention.

[0025] According to an embodiment of the present invention, firstly, a blow-type rat spinal cord injury model is made and evaluated. Select C57BL / 6 mice (purchased from Beijing Weitong Lihua Company) and divide them into 3 groups, namely sham operation group (Sham), vehicle control group (Veh) and flufenamic acid treatment group (FFA), each group All 12 rats were administered by subcutaneous injection.

[0026] The process of spinal cord injury in m...

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Abstract

The invention relates to the new application of flufenamic acid, a traditional analgesic, in treating spinal cord injury, and belongs to the field of biomedicine. In the application of the flufenamicacid in treating spinal cord injury, the flufenamic acid is used for the first time in the treatment of spinal cord injury, and the good treatment effect of the flufenamic acid on the injured spinal cord is proved. Furthermore, the flufenamic acid featuring fat-solubility and low molecular weight is therefore relatively easy to pass through the blood-brain barrier, and the safety of the flufenamicacid has been clinically verified already, hence, flufenamic acid has great potential and advantage in application to the early stage of spinal cord injury.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new use of a traditional analgesic drug flufenamic acid, in particular to the use of flufenamic acid in treating spinal cord injuries. Background technique [0002] Flufenamic acid (FFA) is 2-(3-trifluoromethylanilino)benzoic acid, which has been clinically used as an antipyretic and analgesic for at least 50 years, and has the following structure: [0003] [0004] Spinal cord injury is a common trauma. At present, there are more than 7 million people in the world every year because of spinal cord injury for various reasons, causing inconvenient movement or even paralysis. A series of secondary reactions will occur after spinal cord injury, and these secondary reactions will cause apoptosis, especially neuronal apoptosis and axonal necrosis, and neuronal necrosis is difficult to regenerate, resulting in irreversible repair of spinal cord injury. Therefore, in the early stage of spi...

Claims

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Application Information

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IPC IPC(8): A61K31/196A61P25/00A61P19/08
CPCA61K9/0019A61K31/196A61P19/08A61P25/00
Inventor 姚应涛朱俞婷婷
Owner HUAZHONG UNIV OF SCI & TECH
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