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Polymorphic self-adaptive bio-based endometrial repair material and preparation method thereof

An endometrial repair and self-adaptive technology, applied in the fields of medical formula, tissue regeneration, drug delivery, etc., can solve the problems of complicated stem cell preparation, biological safety, high storage requirements, etc., achieve excellent repair effect, prevent uterine effusion, High safety effect

Pending Publication Date: 2022-01-21
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Preparation Method and Application of a Compound Repair Factor of Human Endometrium Stem Cells" published by Yang Yongli et al., the preparation of stem cells is complicated and costly
There are also some problems in the use of stem cell repair. First, the operation is inconvenient and storage requirements are high; second, there are biosafety issues

Method used

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  • Polymorphic self-adaptive bio-based endometrial repair material and preparation method thereof
  • Polymorphic self-adaptive bio-based endometrial repair material and preparation method thereof
  • Polymorphic self-adaptive bio-based endometrial repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] The present invention provides a method of preparing a multi-morphistically adaptive biological endometrial repair material, including:

[0043] S1: Select the matrix material and activate the matrix material to load the matrix material to activate the activation factor; the matrix material comprises polysaccharide, cellulose and gelatin.

[0044] S2: Injection to the molded reactions, liquid solid phase transitions, or by cropping and molding, by exciting crosslinking reactions.

[0045] When the matrix material is a polysaccharide, the specific steps of S1 are as follows:

[0046] S11: Put polysaccharide into an oven for 50 ° C to 60 ° C for 0.5-3 h, remove excess water, and remove it to normal temperature after sealing;

[0047] S12: A nucleophilic substitution reaction on the molecular chain of the polysaccharide, which is activated, and imparts a polysaccharide active group, and is configured to 2% -10% polysaccharide solution;

[0048] S13: Add an active factor in a 2...

Embodiment 1

[0094] In a specific embodiment: Purification and modification of chitosan matrix materials

[0095] (1) Put the chitosan into an oven at 60 ° C for 3 h, remove excess water, and remove the seal after removal to normal temperature;

[0096] (2) A nucleophilic substitution reaction is performed on the molecular chain of the chitosan, including hydroxybutyrability modification, carboxymethylation modification, mercaptogenization modification, so that chitosan is given to the active group, on one aspect increases The water solubility and plasticity of chitosan will help the subsequent form, and on the other hand, the activity of the chitosan is increased, and the chitosan itself is increased to damaged cells. Configure an 8% solution.

[0097] In a specific embodiment: purification and modification of alginate matrix materials

[0098] (1) Put the alginate in an oven at 60 ° C for 3 h, and the seal is taken out after removal to normal temperature;

[0099] (2) The reaction is carried...

Embodiment 2

[0104] In a specific embodiment: Purification and modification of chitosan matrix materials

[0105] (1) Put the chitan into an oven of 55 ° C for 0.5 h, remove excess water, and take out the seal to be stored after normal temperature;

[0106] (2) A nucleophilic substitution reaction is performed on the molecular chain of the chitosan, including hydroxybutyrability modification, carboxymethylation modification, mercaptogenization modification, so that chitosan is given to the active group, on one aspect increases The water solubility and plasticity of chitosan will help the subsequent form, and on the other hand, the activity of the chitosan is increased, and the chitosan itself is increased to damaged cells. Configure 5% solution.

[0107] In a specific embodiment: purification and modification of alginate matrix materials

[0108] (1) Put the alginate in an oven at 50 ° C for 0.5 h, and the seal is taken out after removal to normal temperature;

[0109] (2) The reaction is carr...

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Abstract

The invention provides a preparation method of a polymorphic self-adaptive bio-based endometrial repair material. The preparation method comprises the following steps: S1, selecting a matrix material, and carrying out activating and grafting on the matrix material to enable the matrix material to load an activating factor; and S2, injecting the mixture to a to-be-formed position in an injection mode, carrying out liquid-solid phase transformation through excitation of a cross-linking reaction, or carrying out solidification through cutting and a mold. The repair material can be applied to repair of various soft tissues including endometrium repair, vagina repair, abdominal cavity endometrium repair, cartilage repair, skin superficial wound repair, skin scar elimination and the like.

Description

[Technical field] [0001] The present invention relates to the field of biomaterials, and more particularly to a polymorphic adaptive biological endometrial repair material and a preparation method. 【Background technique】 [0002] The endometrium includes a mucosa, a functional layer, an endometrical layer, and a base layer. Endometrial impaired adenproplutes and mitochints have swelling, and interstitial cell structures are loose, and fibroblasts are aggregated, and the number of internal surfaces is increased. When the endometrial substrate is severely injured, neutral granulocytes, monocytes, macrophages, lymphocytes and fibroblasts aggregate in endometrial injuries, causing acute or chronic inflammation, which reduces endometrial bandgenes. . The causes of damage to the endometrial base layer include improper surgery, scraping operations. In addition, the endometrial layer of the endometrium can cause the uterine-inner membrane coverage, accompanied by surrounding fiber tissue...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/60A61L27/54A61L27/20A61L27/22
CPCA61L27/50A61L27/60A61L27/54A61L27/20A61L27/222A61L2430/34A61L2430/06A61L2400/06A61L2300/412C08L5/08C08L5/04C08L1/02
Inventor 郑裕东杨惠仪谢亚杰方资元徐祥波乔堃
Owner UNIV OF SCI & TECH BEIJING
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