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Chitosan derivative colloidal solution

A technology of chitosan derivatives and body fluids, applied in the directions of drug delivery, application, medical science, etc., can solve the problems of ineffective debridement, unreasonable configuration, hemostasis and impermeability, etc., to prevent adhesion and healing, and completely degrade safely. Absorbs and promotes healing

Inactive Publication Date: 2018-09-28
张河
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the configuration of the existing chitosan derivative colloid is unreasonable, and cannot effectively debride wounds, inhibit bacteria and anti-inflammation, stop bleeding and prevent leakage, prevent adhesion and promote healing

Method used

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  • Chitosan derivative colloidal solution

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Experimental program
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Effect test

Embodiment 1

[0023] The chitosan derivative colloid of the present invention comprises 25 parts by weight of carboxyaminodextran sodium, 15 parts of carboxymethylcellulose sodium, 5 parts of nicotinamide, 4 parts of glycerin, 1 part of mannitol, microcrystalline 2 parts of cellulose, 1 part of antioxidant, 5 parts of gelatin, 0.5 part of glutaraldehyde, 0.2 part of emulsifier and 60 parts of water for injection, the preparation method of chitosan derivative colloid comprises the following steps:

[0024] S1. Add nicotinamide and sodium carboxymethylcellulose to water for injection in turn, stir to dissolve, add mannitol, heat and stir for 15-20 minutes to obtain solution A;

[0025] S2. Take carboxyaminodextran sodium and add it to the water for injection, heat and stir to dissolve to obtain solution B;

[0026] S3. Mixing solution A and solution B to obtain mixed solution C;

[0027] S4. Add glycerin, microcrystalline cellulose and antioxidant to the mixed solution C, and stir evenly to ...

Embodiment 2

[0030] The chitosan derivative colloid of the present invention comprises 35 parts of carboxyaminodextran sodium, 20 parts of carboxymethylcellulose sodium, 10 parts of nicotinamide, 8 parts of glycerin, 5 parts of mannitol, and 5 parts of microcrystalline cellulose , 3 parts of antioxidant, 15 parts of gelatin, 1 part of glutaraldehyde, 0.6 part of emulsifier and 80 parts of water for injection, the preparation method of chitosan derivative colloid comprises the following steps:

[0031] S1. Add nicotinamide and sodium carboxymethylcellulose to water for injection in turn, stir to dissolve, add mannitol, heat and stir for 15-20 minutes to obtain solution A;

[0032] S2. Take carboxyaminodextran sodium and add it to the water for injection, heat and stir to dissolve to obtain solution B;

[0033] S3. Mixing solution A and solution B to obtain mixed solution C;

[0034] S4. Add glycerin, microcrystalline cellulose and antioxidant to the mixed solution C, and stir evenly to obt...

Embodiment 3

[0037] A chitosan derivative colloid of the present invention comprises 30 parts of carboxyaminodextran sodium, 17 parts of carboxymethyl cellulose sodium, 8 parts of nicotinamide, 6 parts of glycerin, 3 parts of mannitol, and microcrystalline cellulose 3 parts, 2 parts of antioxidant, 10 parts of gelatin, 0.7 part of glutaraldehyde, 0.4 part of emulsifier and 70 parts of water for injection, the preparation method of chitosan derivative colloid comprises the following steps:

[0038] S1. Add nicotinamide and sodium carboxymethylcellulose to water for injection in turn, stir to dissolve, add mannitol, heat and stir for 15-20 minutes to obtain solution A;

[0039] S2. Take carboxyaminodextran sodium and add it to the water for injection, heat and stir to dissolve to obtain solution B;

[0040] S3. Mixing solution A and solution B to obtain mixed solution C;

[0041] S4. Add glycerin, microcrystalline cellulose and antioxidant to the mixed solution C, and stir evenly to obtain ...

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PUM

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Abstract

The invention discloses a chitosan derivative colloidal solution. The solution is composed of 25-35 parts of sodium carboxyamino glucosamine, 15-20 parts of sodium carboxymethylcellulose, 5-10 parts of nicotinamide, 4-8 parts of glycerol, 1-5 parts of mannitol, 2-5 parts of microcrystalline cellulose, 1-3 parts of antioxidant, 5-15 parts of gelatin, 0.5-1 part of glutaraldehyde, 0.2-0.6 part of emulsifier and 60-80 parts of injection water. A preparation method of the solution includes the following steps of S1, adding nicotinamide and sodium carboxymethylcellulose into the injection water, stirring the mixture until the mixture is completely dissolved, adding mannitol, and then obtaining a dissolved solution A; S2, adding sodium carboxyamino glucosamine into the injection water, and conducting heating and stirring for dissolution to obtain a dissolved solution B; S3, mixing the dissolved solution A with the dissolved solution B to obtain a mixed dissolved solution C; S4, adding glycerol, microcrystalline cellulose and the antioxidant into the mixed dissolved solution C, stirring the solution uniformly, and then obtaining the chitosan derivative colloidal solution. The chitosan derivative colloidal solution has the advantages that wounds are effectively cleaned, resistance to bacteria and inflammation is achieved, bleeding is stopped, permeation is prevented, and healing is facilitated.

Description

technical field [0001] The invention relates to the technical field of medical products, in particular to a chitosan derivative colloid used for repairing human skin and wound epithelial tissue. Background technique [0002] At present, the configuration of the existing chitosan derivative colloid is unreasonable, and cannot effectively debride the wound, inhibit bacteria and anti-inflammation, stop bleeding and prevent leakage, prevent adhesion and promote healing. Therefore, urgently need those skilled in the art to research a kind of new chitosan derivative colloid. Contents of the invention [0003] The purpose of the present invention is to provide a chitosan derivative colloid in order to solve the above-mentioned deficiencies in the prior art. [0004] A chitosan derivative colloid of the present invention comprises 25-35 parts of carboxyaminodextran sodium, 15-20 parts of carboxymethylcellulose sodium, 5-10 parts of nicotinamide, 4-4 parts of glycerin in parts by ...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/08A61L24/00
CPCA61L24/104A61L24/001A61L24/0015A61L24/0042A61L24/08A61L2300/202A61L2300/404A61L2400/04C08L1/286C08L1/04C08L5/08
Inventor 张河
Owner 张河
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