Medical sealing adhesive and preparation method thereof

A plugging and solution technology, applied in the fields of application, adhesives, medical science, etc., can solve the problems of slow oxidation and low efficiency of polysaccharide oxidation, and achieve increased aldehyde content, good biocompatibility and bonding performance, and shortened oxidation time Effect

Active Publication Date: 2018-09-28
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bulk dialysis is a slow process, often requiring many days, and therefore, the

Method used

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  • Medical sealing adhesive and preparation method thereof
  • Medical sealing adhesive and preparation method thereof
  • Medical sealing adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of preparation method of medical sealing glue, described preparation method is as follows:

[0032] (1) Place a reactor in a water bath and add ice to the water bath to keep the temperature of the reactor below 20°C. Weigh 2.5g of xanthan gum in the reactor, add 25g of purified water, and stir to dissolve the xanthan gum. Set the ozone generator to gear 1 (220g / h), and pass ozone into the reactor so that the ozone concentration in the solution is 12mg / mL, and the action time is 10s;

[0033] (2) Stop passing through the ozone, wrap the reactor with multi-layer aluminum foil to prevent light from entering, add 2.5g of 0.05% periodate solution dropwise to the solution while stirring, and then add 2g of ethylene glycol to terminate the reaction;

[0034] (3) Put the solution into a dialysis bag, dialyze for 8 hours, take the dialysate to pre-freeze, and freeze-dry at low temperature and low pressure to obtain aldehylated xanthan gum;

[0035] (4) Dissolve 0.5g of ...

Embodiment 2

[0038] A kind of preparation method of medical sealing glue, described preparation method is as follows:

[0039] (1) Place a reactor in a water bath and add ice to the water bath to keep the temperature of the reactor below 20°C. Weigh 0.5g of CMC into the reactor, add 10g of deionized water, and stir to dissolve the CMC. Set the ozone generator to gear 1 (220g / h), and pass ozone into the reactor so that the ozone concentration in the solution is 6mg / mL, and the action time is 5s;

[0040] (2) Stop passing through the ozone, wrap the reactor with multi-layer aluminum foil to prevent light from entering, add 0.5g of 0.01% periodate solution dropwise to the solution while stirring, and then add 0.5g of ethylene glycol to terminate the reaction;

[0041] (3) Put the solution into a dialysis bag, dialyze for 4 hours, take the dialysate to pre-freeze, and freeze-dry at low temperature and low pressure to obtain aldehylated xanthan gum;

[0042] (4) Dissolve 0.2g of aldehylated x...

Embodiment 3

[0045] A kind of preparation method of medical sealing glue, described preparation method is as follows:

[0046] (1) Place a reactor in a water bath and add ice to the water bath to keep the temperature of the reactor below 20°C. Weigh 5g of dextran into the reactor, add 25g of deionized water, and stir to dissolve the dextran. Set the ozone generator to gear 1 (220g / h), and pass ozone into the reactor so that the ozone concentration in the solution is 36mg / mL, and the action time is 30s;

[0047] (2) Stop passing through the ozone, wrap the reactor with multi-layer aluminum foil to prevent light from entering, add 5g of 0.1% periodate solution dropwise to the solution while stirring, and then add 5g of ethylene glycol to terminate the reaction;

[0048] (3) Put the solution into a dialysis bag, dialyze for 12 hours, take the dialysate to pre-freeze, freeze-dry at low temperature and low pressure, and obtain aldylated xanthan gum;

[0049] (4) Dissolve 0.3g of aldehylated x...

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Abstract

The invention relates to a medical sealing adhesive and a preparation method thereof. The medical sealing adhesive is obtained by mixing of an aldehyde polysaccharide solution A and an amino polymer solution B, and the aldehyde content of the aldehyde polysaccharide is 4-10 mmol/g, and the aldehyde polysaccharide is prepared by firstly performing ozone oxidation on a natural polysaccharide or a derivative of the natural polysaccharide, and performing oxidation by using a low-concentration periodate. The method disclosed by the invention firstly selects ozone to oxidize the natural polysaccharide or the derivative of the natural polysaccharide, and then selects the low-concentration periodate for further oxidization; and the method significantly reduces a using amount of the periodate, shortens the oxidation time, and improves the aldehyde content of the aldehyde polysaccharide, thereby improving the bonding properties of the medical sealing adhesive.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a medical sealing glue and a preparation method thereof. Background technique [0002] There are many types of medical plugging glues currently used clinically. For example, fibrin glue, cyanoacrylic glue, etc. The main components of fibrin glue are fibrin and thrombin, the main source of which is extracted from human blood, and there is a risk of virus infection; cyanoacrylic glue has heat and is not easy to degrade during clinical use, and it is not easy to degrade with surrounding tissues. Compatibility and other issues. Several types of hydrogel tissue adhesives have been developed, which have been improved to have suitable adhesive and cohesive properties, and are safe and non-toxic. [0003] Sugars refer to polyhydric aldehydes, ketones, alcohols and their oxidized or reduced derivatives, as well as compounds linked by their glycosidic bonds. Polysaccharide refers to a ...

Claims

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Application Information

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IPC IPC(8): C09J167/02C09J11/08C08B37/02C08B11/12A61L24/08A61L24/04A61L24/00
CPCA61L24/001A61L24/046A61L24/08C08B11/12C08B37/0006C08B37/0033C08L2205/03C09J11/08C09J167/02C08L79/02C08L5/02C08L67/02
Inventor 林丽敏邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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