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A ginseng-Bulbus Fritillariae Ussuriensis composition and a preparation method and application thereof

A technology of fritillary fritillary and a composition, applied in the fritillaria fritillary and its preparation, in the field of ginseng, can solve problems such as lack of therapeutic drugs, achieve the effects of simple composition of medicinal flavor, overcoming poor therapeutic effect, and good prevention and treatment effect

Active Publication Date: 2018-10-09
YANBIAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment of clinical PF still lacks ideal therapeutic drugs

Method used

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  • A ginseng-Bulbus Fritillariae Ussuriensis composition and a preparation method and application thereof
  • A ginseng-Bulbus Fritillariae Ussuriensis composition and a preparation method and application thereof

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preparation example Construction

[0036] The present invention also provides a preparation method of the composition described in the above technical scheme, comprising the following steps:

[0037] 1) Extracting ginseng and peace fritillary with an ethanol solution with a volume percentage of 65-75% as a solvent, the extraction includes: soaking ginseng and peace fritillary in the solvent for 1-3 hours to obtain raw materials after soaking, soaking Finally, the raw material is mixed with 12 to 16 times the amount of solvent, and the first heating and reflux extraction is carried out for 1 to 3 hours to obtain the first filtrate and the first filter residue; the first filter residue is mixed with 12 to 18 times the amount of solvent, and the second heating and reflux is carried out Extracting for 1 to 3 hours to obtain a second filtrate and a second filter residue; combining the first filtrate and the second filtrate to obtain a heated reflux extract;

[0038] 2) Purify the heated reflux extract obtained in st...

Embodiment 1

[0055] 1. Extraction Take 6000g ginseng decoction pieces and 4000g flat fritillaria decoction pieces, use 70% ethanol as the solvent, soak for 1h, heat and reflux extraction twice, the first time 12 times the amount of solvent, 2h, the second time 12 times the amount of solvent, 2h , combined 2 filtrates to obtain the extract;

[0056] 2. Refining is carried out by adsorption clarification method, the extract is concentrated to a solid-liquid ratio of 1:2, and at 50°C, slowly add ZTC 1+1 natural clarifier component B, the dosage is 8%, and it is stirred once every 30 minutes. After an interval of 3 hours, add component A in an amount of 4%, let it stand for 6 hours, take the supernatant, filter it, and obtain the refined solution;

[0057] 3. Concentrate and combine the refined solution, and concentrate the filtrate to an extract with a relative density of 1.2 at 50°C;

[0058] 4. Drying The extract is prepared into extract powder by a spray drying method, and passed through ...

Embodiment 2

[0063] 1. Extraction Take 6000g ginseng decoction pieces and 6000g flat fritillaria decoction pieces, use 70% ethanol as the solvent, soak for 2 hours, heat and reflux extraction twice, the first time 14 times the amount of solvent, 2h, the second time 12 times the amount of solvent, 2h , combined 2 filtrates to obtain the extract;

[0064] 2. Refining is carried out by adsorption clarification method, the extract is concentrated to a ratio of material to liquid of 1:1, at 60°C, slowly add ZTC 1+1 natural clarifier component B, the dosage is 4.5%, stir once every 30min, After an interval of 2 hours, add component A in an amount of 2.25%, let it stand for 8 hours, take the supernatant, filter it, and obtain the refined solution;

[0065] 3. Concentrate and combine the refined solution, and concentrate the filtrate to an extract with a relative density of 1.3 at 50°C;

[0066] 4. Drying The extract is dried into a dry paste by freeze drying, the dry extract is pulverized, and p...

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Abstract

The invention relates to a ginseng-Bulbus Fritillariae Ussuriensis composition and a preparation method and application thereof, and belongs to the technical field of research on new traditional Chinese medicines treating pulmonary fibrosis disease. The composition is prepared by 1) subjecting ginseng and Bulbus Fritillariae Ussuriensis to extraction with ethanol being adopted as a solvent to obtain a heating reflux extract liquid; 2) purifying the extract liquid obtained in the step 1) through an adsorption clarification process to obtain a purified liquid; and 3) concentrating the purified liquid obtained in the step 2) until the relative density of obtained extract at 50 DEG C is 1.1-1.3, so that the composition is prepared. Medicines prepared from the composition can be used for preventing and treating pulmonary fibrosis.

Description

technical field [0001] The invention relates to the technical field of research on new traditional Chinese medicines for treating pulmonary fibrosis, in particular to a composition of ginseng and flat fritillaria and its preparation method and application. Background technique [0002] Pulmonary fibrosis (PF) belongs to the category of "cough, shortness of breath, dyspnea, pulmonary fistula", "pulmonary obstruction" or "lung atrophy" in traditional Chinese medicine. It is a large group of lung diseases characterized by inflammatory injury and tissue structure destruction, and it is a common disease in recent years. It is a chronic pulmonary inflammatory disease, mainly caused by pulmonary interstitial and alveolar epithelial cells and vascular lesions, continuous alveolar damage, fibroblast proliferation and a large amount of extracellular matrix deposition, which in turn leads to the destruction of lung tissue and the formation of pulmonary fibrosis change. So far, the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/20A61P11/00
CPCA61K9/2031A61K36/258A61K36/8966A61K2236/333A61K2236/53A61P11/00A61K2300/00
Inventor 郭建鹏关琪轩左阿龙
Owner YANBIAN UNIV
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