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Rapid detection type paper chip

A paper chip and fast technology, applied in the field of clinical testing, can solve the problems of strict requirements on the detection time of color change, affecting the results of optical detection, and no way to process blood samples in time, so as to reduce background color interference, reduce transfer loss, and time Reduced effect

Pending Publication Date: 2018-10-12
宁波中微智能科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing vertical dry chemical test paper technology usually includes a multi-layer structure, such as a reaction layer, a sample separation layer, a glass fiber layer and a mesh layer. Due to individual differences, it is difficult to control the amount of samples collected by fingertip blood sampling. The carrier has a certain degree of saturation in the absorption of the liquid, and the detection time corresponding to the color change has strict requirements. There is no way to time the excess blood samples, and these excess blood samples will affect the results of optical detection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Design and manufacture of embodiment 1 base material

[0046] Such as figure 1 As shown, the structure of the chemical and immune index detection paper chip substrate of the present invention is designed by vector drawing software, specifically including the following structural areas: hydrophobic boundary 2 and hydrophobic and oleophobic boundary 3, surrounded by a specific shape in the middle Hydrophilic area, the hydrophilic area includes at least three parts: pretreatment area 4, detection area 6 and water absorption area 8, the corresponding shape is arranged symmetrically around the center or in the form of a regular polygon, such as equilateral triangle, square, regular pentagon , regular hexagon, etc., and the dimensions are respectively 2-5mm in diameter of the pretreatment area, 2-5mm in diameter of the detection area, and 2-7mm in side length of the water-absorbing area. The side length is 7mm, and these three areas are connected by microchannel 5 and microc...

Embodiment 2

[0051] The assembly of embodiment 2 paper chip

[0052] Press the base material 1, the upper cover plate 9, the blood filter membrane 13 and the lower cover plate 14 figure 1 The structure shown is assembled into a paper chip;

[0053] The paper chip comprises a base material 1, an upper cover plate 9, a blood filter membrane 13 and a lower cover plate 14, and the upper cover plate 9, the blood filter membrane 13 and the lower cover plate 14 are arranged vertically from top to bottom, and the base plate The material 1 is adhered in the middle of the upper cover plate 9 and the lower cover plate 14;

[0054] Wherein, the substrate 1 includes three parts: the hydrophobic boundary 2, the hydrophobic and oleophobic boundary 3, and the middle hydrophilic region, and the hydrophobic boundary 2 separates the hydrophobic and oleophobic boundary 3 from the middle hydrophilic region, starting from the middle hydrophilic region, Extend outward in sequence to hydrophobic boundary 2, and...

Embodiment 3

[0057] Embodiment 3 detects the cholesterol of different concentrations

[0058] Prepare whole blood solutions with concentrations of 50 mg / dL, 100 mg / dL, 150 mg / dL, 200 mg / dL, and 250 mg / dL, respectively take 5 μL of the above whole blood solutions, and add them to the chemical and immune index detection described in Example 2 of the present invention Paper chips were tested and analyzed; the test results were as follows: Figure 5 shown;

[0059] Depend on Figure 5 It can be seen that the rapid detection paper chip of the present invention can well realize the detection of cholesterol in blood, and the detection result is stable and accurate.

[0060] This embodiment takes the detection of cholesterol as an example, and it does not mean that only the detection of cholesterol can be completed.

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Abstract

The invention provides a rapid detection type paper chip. The paper chip comprises a base material (1), an upper cover plate (9), a blood filtering membrane (13) and a lower cover plate (14), whereinthe upper cover plate (9), the blood filtering membrane (13) and the lower cover plate (14) are vertically arrayed from top to bottom; the base material (1) is stuck between the upper cover plate (9)and the lower cover plate (14). According to the rapid detection type paper chip provided by the invention, a pre-treatment process and a detection process are subjected to a series of improvement including separation and the like through a manner of selecting a double-hydrophobic region, defects of traditional microfluidic are overcome and the transportation loss of a sample in different regionsis reduced; the stability and accuracy of a detection result are ensured, and the rapid detection type paper chip has a wide application prospect and huge market value.

Description

technical field [0001] The invention relates to the technical field of clinical testing, and relates to a paper chip, in particular to a paper chip for rapid detection. Background technique [0002] Microfluidic paper chip is an emerging microfluidic analysis technology platform, which has the advantages of low cost, easy fabrication, and portability, and has great application prospects in clinical diagnosis, food quality control, and environmental monitoring. Paper chips produced by traditional methods cannot resist organic solvents such as absolute ethanol, acetone and isopropanol, thus limiting the detection application of paper chips. [0003] At present, the content of biochemical indicators in blood samples at home and abroad includes liquid detection method and dry chemical test paper detection method. Dry chemical test paper has the characteristics of simple use, convenient operation and quick results. Dry chemical test paper usually stacks carriers with reaction r...

Claims

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Application Information

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IPC IPC(8): G01N33/50G01N33/92G01N1/34G01N1/36B01L3/00
CPCG01N1/34G01N1/36G01N33/5005G01N33/92B01L3/5027B01L2200/10
Inventor 王腾飞钟小军郭嘉杰游璠
Owner 宁波中微智能科技有限公司
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