Moxifloxacin pharmaceutical preparation
A pharmaceutical preparation, the technology of moxifloxacin, applied in the field of moxifloxacin pharmaceutical preparations, can solve the problems of discoloration of moxifloxacin and inability to overcome the discoloration of moxifloxacin hydrochloride
Active Publication Date: 2018-10-16
BEIJING WINSUNNY PHARMA CO LTD
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- Abstract
- Description
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AI Technical Summary
Problems solved by technology
However, the inventors found that the preparation still cannot overcome the discoloration problem of moxifloxacin hydrochloride
[0008] Therefore, further studies on moxifloxacin formulations are needed to solve the problem of discoloration of moxifloxacin
Method used
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Experimental program
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Effect test
Embodiment 1
[0023]
[0024] Preparation:
[0025] a. Mix moxifloxacin hydrochloride, gallic acid, sodium oleate, microcrystalline cellulose, lactose, and croscarmellose sodium evenly to prepare a mixture;
[0026] b. adding 30% ethanol aqueous solution to step a, granulating to obtain drug granules;
[0027] c. Compressing the drug granules into tablets.
Embodiment 2
[0029]
[0030] The preparation method is the same as in Example 1.
Embodiment 3
[0032]
[0033] The preparation method is the same as in Example 1.
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The invention relates to a moxifloxacin pharmaceutical preparation which specifically comprises moxifloxacin or a salt thereof, a diluent, a disintegrating agent, gallic acid and sodium oleate. According to the moxifloxacin pharmaceutical preparation, by using the gallic acid and the sodium oleate, the color changing problem in the preparation and storage processes of the moxifloxacin preparationcan be solved quite well; and meanwhile, the problem of poor fluidity of the moxifloxacin can further be effectively relieved, preparation smoothness of the moxifloxacin pharmaceutical preparation isensured, and the moxifloxacin pharmaceutical preparation is suitable for industrial mass production.
Description
technical field [0001] The invention relates to a pharmaceutical preparation of an antibacterial drug, in particular to a pharmaceutical preparation of moxifloxacin, and a preparation method of the preparation. Background technique [0002] Moxifloxacin hydrochloride is a broad-spectrum and active 8-methoxyfluoroquinolone antibacterial drug. It has broad-spectrum antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, anaerobic bacteria, acid-fast bacteria, and atypical microorganisms such as Mycoplasma, Chlamydia and Legionella. The antibacterial mechanism is to interfere with II and IV topoisomerases, which are key enzymes in controlling DNA topology, DNA replication, repair and transcription. Moxifloxacin is the fourth generation of fluoroquinolone antibiotics. Because of its broad antibacterial spectrum, low drug resistance, strong antibacterial effect, long half-life, and low phototoxicity, it has become a very effective anti-infective agent. ...
Claims
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IPC IPC(8): A61K31/4709A61K47/12A61K47/38A61K47/32A61P31/04
CPCA61K31/4709A61K47/12
Inventor 黄玉锋王帅杨西邈耿玉先产运霞
Owner BEIJING WINSUNNY PHARMA CO LTD
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