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Linggui Zhugan decoction compound granules and preparation method thereof

A technology of Lingguizhu and granules, applied in the field of traditional Chinese medicine compound granules, can solve the problems of inconvenience to carry, slow effect, poor absorption, etc., and achieve the effects of convenient transportation, good taste and stable quality.

Pending Publication Date: 2018-10-16
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, the object of the present invention is to overcome the problems of poor taste and inconvenient carrying of the existing Linggui Zhugan Decoction, the formulations of Linggui Zhugan Decoction pills and tablets, relatively poor absorption and slow effect, etc., and provide a Linggui Zhugan Decoction Gantang compound granules and preparation method thereof, and a preparation method of Lingguizhugantang freeze-dried powder

Method used

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  • Linggui Zhugan decoction compound granules and preparation method thereof
  • Linggui Zhugan decoction compound granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prepare Linggui Zhugan Decoction Compound Granules as follows:

[0041] Weigh 12g of Poria cocos, 9g of cassia twig, 9g of Atractylodes macrocephala and 6g of roasted licorice;

[0042] Distilling Cinnamon Twig and Atractylodes Rhizoma Atractylodes Rhizome with steam respectively to obtain the volatile oil components of Cinnamon Twig and Atractylodes Rhizome;

[0043] Add Guizhi and Atractylodes macrocephala residues to Poria cocos and Radix Glycyrrhizae, add 8 times the amount of ultrapure water for extraction, the extraction time is 1.5 hours each time, and extract 3 times;

[0044] Freeze-drying the extract to obtain Lingguizhugantang freeze-dried powder;

[0045]Mix the prepared Linggui Zhugan Decoction freeze-dried powder with soluble starch and dextrin according to the ratio of 1:1:1 by weight and sieve, add 50% ethanol to make soft material, sieve to make granules, and Vacuum-dried at 60°C to constant weight, sprayed into the volatile oil of Guizhi and Atractyl...

Embodiment 2

[0048] Prepare Linggui Zhugan Decoction Compound Granules as follows:

[0049] Weigh 12g of Poria cocos, 9g of cassia twig, 9g of Atractylodes macrocephala and 6g of roasted licorice;

[0050] Distilling Cinnamon Twig and Atractylodes Rhizoma Atractylodes Rhizome with steam respectively to obtain the volatile oil components of Cinnamon Twig and Atractylodes Rhizome;

[0051] Add Guizhi and Atractylodes macrocephala residues to Poria cocos and Radix Glycyrrhizae, add 8 times the amount of ultrapure water for extraction, the extraction time is 1.5 hours each time, and extract 3 times;

[0052] Freeze-drying the extract to obtain Lingguizhugantang freeze-dried powder;

[0053] Mix the prepared Lingguizhugantang freeze-dried powder with powdered sugar and dextrin according to the ratio of 1:3:3 by weight and sieve, add 50% ethanol to make soft material, sieve to make granules, and Vacuum-dried at 50°C to constant weight, sprayed into the volatile oil of Guizhi and Atractylodes m...

Embodiment 3

[0055] Prepare Linggui Zhugan Decoction Compound Granules as follows:

[0056] Weigh 12g of Poria cocos, 9g of cassia twig, 9g of Atractylodes macrocephala and 6g of roasted licorice;

[0057] Distilling Cinnamon Twig and Atractylodes Rhizoma Atractylodes Rhizome with steam respectively to obtain the volatile oil components of Cinnamon Twig and Atractylodes Rhizome;

[0058] Add cinnamon sticks and Atractylodes macrocephala residues to Poria cocos and Zhigancao, add 8 times the amount of ultrapure water for extraction, the extraction time is 1 hour each time, and extract 2 times;

[0059] Freeze-drying the extract to obtain Lingguizhugantang freeze-dried powder;

[0060] Mix the prepared Linggui Zhugan Decoction freeze-dried powder with soluble starch and dextrin according to the ratio of 1:1:1 by weight and sieve, add 50% ethanol to make soft material, sieve to make granules, and Vacuum-dried at 50°C to constant weight, sprayed into the volatile oil of Guizhi and Atractylod...

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Abstract

The invention discloses Linggui Zhugan decoction compound granules and a preparation method thereof. The preparation method specifically comprises the steps that, in parts by weight, raw matierals, i.e. 4 parts of poria cocos, 3 parts of ramulus cinnamomi, 3 parts of rhizoma atractylodis macrocephalae and 2 parts of honey-fried licorice root are weighed, ramulus cinnamomi and rhizoma atractylodismacrocephalae are subjected to steam distillation, a volatile oil ingredient is obtained, the residue of ramulus cinnamomi and rhizoma atractylodis macrocephalae, poria cocos and honey-fried licoriceroot are subjected to water extraction after 8-12 times of water are added, water extraction is conducted for 1-2 hours each time, and water extraction is conducted for 1-3 times; the extract is produced to be freeze-drying powder, an assistant is added into the freeze-drying powder, the freeze-drying powder is produced to be granules, the volatile oil is sprayed into the surface of the obtained granules, and the Linggui Zhugan decoction compound granules are obtained. The granule product prepared by adopting the preparation method is stable in quality, good in taste and easy to carry and take, and meanwhile, the drug activity of the Linggui Zhugan decoction compound granules can be well maintained. The invention further provides Linggui Zhugan decoction compound particles and a preparation method thereof.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine compound granules, and in particular relates to a traditional Chinese medicine compound Linggui Zhugan Decoction compound granule and a preparation method thereof. Background technique [0002] The clinical manifestations of chronic heart failure belong to the categories of TCM "palpitations", "edema", "phlegm retention", "breathing syndrome", "cardiorrhea", and "out of syndrome". , yang deficiency, marked by mutual resistance of water, dampness, phlegm, and blood stasis, deficiency and decline of heart yang qi is the key point of its pathology, heart yang qi deficiency is the key to the pathogenesis of this disease, throughout the pathology of chronic heart failure, benefiting qi and yang is its basic rule of law. [0003] Linggui Zhugan Decoction comes from Zhang Zhongjing's "Treatise on Febrile and Miscellaneous Diseases" in the Han Dynasty. It is composed of four traditio...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K9/16A61P9/04
CPCA61K9/1652A61K36/076A61K36/284A61K36/484A61K36/54A61K2236/331A61K2236/51A61P9/04A61K2300/00
Inventor 黄金玲周鹏华芳丁婉雪
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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