Veterinary acidifying amoxicillin soluble powder and preparation method thereof

A technology of amoxicillin and amoxicillin trihydrate, which is applied in the field of veterinary acidified amoxicillin soluble powder and its preparation, can solve the problem of affecting the efficacy and stability of amoxicillin, high requirements for production equipment conditions, and preparation problems. Complicated process and other issues, to achieve the effect of good taste and flavor, not easy to degrade, and good solubility

Inactive Publication Date: 2018-10-19
HENAN SOAR VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that adding basic excipients can increase the solubility of amoxicillin, but the alkaline environment can destroy the β-lactam four-membered ring of amoxicillin molecules, affecting the efficacy and stability of amoxicillin
It is also reported that amoxicillin is made into nano-scale, microcapsules, etc., although the drug effect of amoxicillin is delayed, but its inherent curative effect is reduced, and the preparation process is more complicated, and the requirements for production equipment are higher.

Method used

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  • Veterinary acidifying amoxicillin soluble powder and preparation method thereof
  • Veterinary acidifying amoxicillin soluble powder and preparation method thereof
  • Veterinary acidifying amoxicillin soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A veterinary acidified amoxicillin soluble powder, which comprises the following parts by weight: 30 parts of amoxicillin trihydrate, 45 parts of polyethylene glycol-6000, 15 parts of sodium tripolyphosphate and 10 parts of fumaric acid.

[0023] Preparation method, the steps are as follows:

[0024] (1) Heat and melt polyethylene glycol-6000, add fumaric acid while it is hot, stir and mix well, cool at -10°C for 5 hours, crush and sieve after cooling, the mesh size of the sieve is 100 mesh;

[0025] (2) Amoxicillin trihydrate and sodium tripolyphosphate were pulverized and sieved separately, the mesh number of the sieve was 100 mesh, and mixed evenly after pulverization;

[0026] (3) Mix the materials obtained in step (1) and step (2) with a three-dimensional motion mixer, the spindle speed is 10 r / min, and the mixing time is 40 min;

[0027] (4) Subpackaging and testing the materials obtained in step (3) to obtain amoxicillin soluble powder.

Embodiment 2

[0029] A veterinary acidified amoxicillin soluble powder, which comprises the following parts by weight: 30 parts of amoxicillin trihydrate, 50 parts of polyethylene glycol-6000, 10 parts of sodium tripolyphosphate and 10 parts of fumaric acid.

[0030] The preparation method is the same as in Example 1.

Embodiment 3

[0032] A veterinary acidified amoxicillin soluble powder, which comprises the following parts by weight: 30 parts of amoxicillin trihydrate, 50 parts of polyethylene glycol-6000, 15 parts of sodium tripolyphosphate and 5 parts of fumaric acid.

[0033] The preparation method is the same as in Example 1.

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Abstract

The invention belongs to the technical field of veterinary preparations, and discloses a veterinary acidifying amoxicillin soluble powder and a preparation method thereof. The veterinary acidifying amoxicillin soluble powder is prepared from the following 100 parts of components by weight: 10 to 35 parts of amoxicillin trihydrate, 30 to 70 parts of polyethylene glycol-6000, 10 to 20 parts of sodium tripolyphosphate, and 5 to 10 parts of fumarate. The preparation method comprises the following steps of heating and melting the polyethylene glycol-6000, adding the fumarate, uniformly mixing, cooling and crushing; respectively crushing the amoxicillin trihydrate and the sodium tripolyphosphate; uniformly mixing all obtained materials, so as to obtain the veterinary acidifying amoxicillin soluble powder. The prepared veterinary acidifying amoxicillin soluble powder has the advantages that the dissolving degree is high; after dissolving, the medicine is stable and is difficult to degrade.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, in particular to a veterinary acidified amoxicillin soluble powder and a preparation method thereof. Background technique [0002] Amoxicillin is one of the most widely used oral semi-synthetic penicillins at present, with strong bactericidal effect and strong ability to penetrate cell walls. After oral administration, the β-lactam four-membered ring in the drug molecule is immediately hydrolyzed to form a peptide bond, which quickly binds to the transpeptidase in the bacteria to inactivate it, cutting off the only way for the bacteria to synthesize glycopeptides and cell walls through the transpeptidase. Bacterial cells quickly become spherical and rupture and dissolve, and the bacteria eventually burst and die because the cell wall cannot be synthesized and water penetrates. Amoxicillin has a good antibacterial effect on Staphylococcus suis, Streptococcus, Haemophilus para...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/02A61K47/12A61K47/10A61K31/43A61P31/04
CPCA61K9/143A61K9/145A61K9/146A61K31/43A61P31/04
Inventor 郝小倩李凌峰郭建军胡帅李灵娟
Owner HENAN SOAR VETERINARY PHARMA
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