Isolation system, control method and biochip between microvalve and liquid

Abstract

The invention discloses an isolation system between a microvalve and a liquid, a control method and a biochip. The isolation system between the microvalve and the liquid includes a reagent chamber, a first pipeline, a second pipeline and a reaction chamber; the reagent chamber is used to store liquid, and the liquid outlet of the reagent chamber is connected to the first pipeline One end communicates, the other end of the first pipeline is separated from one end of the second pipeline by a normally closed microvalve, and the other end of the second pipeline communicates with the reaction chamber; there is an air column in the first pipeline, One end of the air column contacts the normally closed microvalve, the other end of the air column contacts the liquid, and the first pipeline communicates with the second pipeline when the normally closed microvalve is opened. The invention ensures that the liquid will not flow into the microvalve during the storage process, and the storage liquid will not be affected during the change of the microvalve.

Description

technical field [0001] The invention relates to an isolation system between a microvalve and a liquid, a control method and a biochip, belonging to the field of biochip detection. Background technique [0002] Microfluidic chip technology integrates the basic operation units such as sample preparation, reaction, separation, and detection in the process of biological, chemical, and medical analysis into a micron-scale chip to automatically complete the entire analysis process. Due to its great potential in the fields of biology, chemistry, and medicine, it has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. [0003] At present, the reagents used in microfluidic chips are mostly injected externally, and driven by external forces, the reagents flow according to the pipeline. Now the microfluidic chip detection reagent is added into the chip reagent chamber in advance, no need to inject the rea...

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Problems solved by technology

However, this patent uses ice as the spool, so it cannot be used for storage of reagents, and there is no spool under normal conditions; further, ice is easy to react with reagents, and ice is too large as a spool (it cannot be used as a valve core). to the micron level), precise control cannot be achieved. In addition, if the patent is used on a microfluidic chip, then the chip needs to be implanted with circuits, which will further increase the difficulty of chip manufacturing and reduce its reliability.

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