Flavoring agent adopting traditional Chinese medicine recipe granules and preparation method and use method thereof

A technology of traditional Chinese medicine formula granules and flavoring agents, which is applied in the direction of medical formulas, medical preparations of non-active ingredients, and capsule delivery, etc. limited and other problems, to achieve good flavoring effect, low price, and pure sweetness

Inactive Publication Date: 2018-10-23
JIANGSU BAIJIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, film coating technology is often used for taste-masking of tablets, but for traditional Chinese medicine formula granules, due to the large specific surface area of ​​the granules, the amount of adjuvant required for coating is large, so it is not suitable for taste-masking of traditional Chinese medicine formula granules; The combination technology is to wrap the drug in the cavity of the main molecule such as cyclodextrin, which can reduce the contact between the drug and the taste buds, and achieve the purpose of flavoring. The ratio is more than 1:1, so it is not suitable for flavor correction of traditional Chinese medicine formula granules; there are few domestic researches on resin adsorption technology, and there are few ion exchange resin materials that can be used for medicine; waxy material encapsulation technology, emulsion encapsulation technology , The effervescent technology is complicated, and the operation requirements are high; the use of sweeteners or food flavors alone has limited taste correction effects, especially in the case of many components and large doses of traditional Chinese medicine compound, the simple use of some sweeteners or food flavors cannot Good taste masking effect

Method used

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  • Flavoring agent adopting traditional Chinese medicine recipe granules and preparation method and use method thereof
  • Flavoring agent adopting traditional Chinese medicine recipe granules and preparation method and use method thereof
  • Flavoring agent adopting traditional Chinese medicine recipe granules and preparation method and use method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Traditional Chinese medicine formula granule flavoring agent and preparation method thereof:

[0029] Dosage (1 bag)

[0030]

[0031] Mix carrageenan, konjac gum, sucralose, ethyl maltol, hydroxylated phospholipids, maltodextrin and lemon flavor evenly, add appropriate amount of water as binder, make wet granules, dry at 50-60°C, Made into traditional Chinese medicine formula granule flavoring agent.

[0032] Take 1 bag (0.5g) of Coptidis traditional Chinese medicine formula granules and 1 bag of corrective agent and pour it into a container, add 100ml of hot water, stir evenly, put it in a 4°C environment to cool, and take it after it is frozen. The results show that Coptidis Chinese medicine can be significantly improved. Bitter taste of formula granules.

Embodiment 2

[0034] Traditional Chinese medicine formula granule flavoring agent and preparation method thereof:

[0035] Dosage (1 bag)

[0036]

[0037] Mix carrageenan, konjac gum, sucralose, ethyl maltol, hydroxylated phospholipids, maltodextrin and peach flavor evenly, add an appropriate amount of water as a binder, make wet granules, and dry at 50-60°C , made into traditional Chinese medicine formula granule flavoring agent.

[0038] Take 1 bag (0.5g) of Coptidis traditional Chinese medicine formula granules and 1 bag of corrective agent and pour it into a container, add 100ml of hot water, stir evenly, put it in a 4°C environment to cool, and take it after it is frozen. The results show that Coptidis Chinese medicine can be significantly improved. Bitter taste of formula granules.

Embodiment 3

[0040] Traditional Chinese medicine formula granule flavoring agent and preparation method thereof:

[0041] Dosage (1 bag)

[0042]

[0043] Mix carrageenan, konjac gum, sucralose, ethyl maltol, hydroxylated phospholipids, maltodextrin and peach flavor evenly, add an appropriate amount of water as a binder, make wet granules, and dry at 50-60°C , made into traditional Chinese medicine formula granule flavoring agent.

[0044] Take 1 bag of tangerine peel, honeysuckle, and forsythia traditional Chinese medicine formula granules (3.5g in total) and 1 bag of flavoring agent, pour it into a container, add 100ml of hot water, stir well, cool it to room temperature, and take it after freezing. The results show that It can significantly improve the bitterness and astringency of tangerine peel, honeysuckle, and forsythia traditional Chinese medicine formula granules.

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PUM

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Abstract

The invention relates to a flavoring agent adopting a traditional Chinese medicine recipe granules and a preparation method and a use method thereof. The flavoring agent is used for improving the mouth feel of single or compound granule using the traditional Chinese medicine recipe. The flavoring agent is prepared from the following raw materials in percentage by weight: 30 to 60% of carrageenan and konjac gum mixture, 0.3 to 1.0% of sucralose, 0.5 to 0.8% of ethyl maltol, 1 to 4% of hydroxylated phospholipid, 35 to 60% of maltodextrin, and 0.001% to 0.004% of fruit-flavor essence. The preparation method adopts the technology process with the following steps of uniformly mixing the carrageenan and konjac gum, sucralose, ethyl maltol, hydroxylated phospholipid, maltodextrin and the fruit-flavor essence, adding a proper amount of water as an adhesive, preparing into wettable granules, and drying at the temperature of 50 to 60 DEG C, so as to prepare the granule flavoring agent adopting the traditional Chinese medicine recipe. The use method comprises the following steps of pouring the to-be-taken granule using the traditional Chinese medicine recipe and the flavoring agent into a container, adding hot water, stirring, freezing, and then taking. The flavoring agent has the advantages that the technology is simple, the convenience in use is realized, and the good flavor masking effect is realized.

Description

(1) Technical field [0001] The invention relates to a traditional Chinese medicine formula granule flavoring agent and a preparation method and application method thereof. It is used to improve the taste of single or compound Chinese medicine formula granules. It belongs to the field of traditional Chinese medicine preparations. (2) Background technology [0002] Traditional Chinese medicine formula granules are single-flavor granules prepared by water extraction, concentration and drying under the guidance of traditional Chinese medicine theory. It is recognized and accepted by clinical patients and doctors for its stable quality, accurate dosage, convenient administration, safety and sanitation. However, due to the high drug concentration and poor taste of traditional Chinese medicine formula granules, they often have unpleasant tastes such as bitterness, astringency, and sourness, which make patients feel uncomfortable and even vomit when they use them, especially child...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/26A61K47/24
CPCA61K9/5015A61K9/5036
Inventor 石国剑
Owner JIANGSU BAIJIAN PHARMA TECH CO LTD
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