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Method for rapidly judging elution start point and terminal point during macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof

A technology of danshensu sodium and macroporous resin, which is applied in the field of quality inspection of traditional Chinese medicine production, can solve the problems of excessive eluent consumption and long elution time, and achieve low detection cost, fast and simple judgment process, and fast measurement speed Effect

Inactive Publication Date: 2018-10-23
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first object of the present invention is to provide a method for quickly judging the elution starting point and end point of the danshensu sodium extract in the macroporous resin adsorption separation process. The method is fast, simple, accurate, reliable, and reproducible, and can be used for The rapid determination of effective components in the adsorption and separation stage of sodium extract with macroporous resin has improved the existing problems of excessive eluent consumption and long elution time in the adsorption and separation process of Salvia miltiorrhiza

Method used

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  • Method for rapidly judging elution start point and terminal point during macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof
  • Method for rapidly judging elution start point and terminal point during macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof
  • Method for rapidly judging elution start point and terminal point during macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof

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Embodiment approach

[0064] As a preferred embodiment of the present invention, the elution process of Danshensu sodium extract comprises the following steps:

[0065] After the danshensu sodium extract is absorbed by the macroporous resin, it is washed with purified water, and at the same time when the danshensu sodium effluent is collected, the danshensu sodium effluent is sampled and separated every 1 to 10 minutes to obtain Different batches of danshensu sodium effluent.

[0066] Since the danshensu sodium extract is easily soluble in water, purified water can be used for elution, and the danshensu sodium effluent obtained at this time can also be called danshensu sodium washing solution. Wherein, typical but non-limiting time intervals for sample collection are 1 min, 2 min, 3 min, 4 min, 5 min, 6 min, 7 min, 8 min, 9 min or 10 min.

[0067] As a preferred embodiment of the present invention, during the elution process of the danshensu sodium extract, the danshensu sodium extract is absorbed...

Embodiment 1

[0085] A method for quickly judging the elution start point and end point of the danshensu sodium extract in the macroporous resin adsorption separation process provided in this embodiment includes the following steps:

[0086] (1) Raw material processing: 300kg of salvia miltiorrhiza medicinal material is physically obtained to obtain its decoction pieces;

[0087] (2) Process treatment: Danshensu decoction pieces were produced and prepared according to actual production requirements, and Danshensu sodium extract was absorbed by macroporous resin, then washed with 6BV purified water at a flow rate of 6BV / h, collect samples of the danshensu sodium effluent every 2 minutes, pass through a 0.45 μm microporous membrane, and seal and store different batches of danshensu sodium effluent;

[0088] (3) Establishment of the calibration model: different batches of danshensu sodium effluent obtained from the elution process of the danshensu sodium extract were selected as samples to fo...

Embodiment 2

[0115] A method for quickly judging the elution start point and end point of the danshensu sodium extract in the macroporous resin adsorption separation process provided in this embodiment includes the following steps:

[0116] (1) Raw material processing: 300kg of salvia miltiorrhiza medicinal material is physically obtained to obtain its decoction pieces;

[0117] (2) Process treatment: Danshensu decoction pieces were produced and prepared according to the actual production requirements, and the Danshensu sodium extract was absorbed by macroporous resin, and then washed with 12BV purified water at a flow rate of 12BV / h, collect samples of the danshensu sodium effluent every 8 minutes, pass through a 0.45 μm microporous membrane, and seal and store different batches of danshensu sodium effluent;

[0118] (3) Establishment of the calibration model: different batches of danshensu sodium effluent obtained from the elution process of the danshensu sodium extract were selected as...

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Abstract

The invention provides a method for rapidly judging the elution start point and terminal point during the macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof, and relates to the technical field of quality detection in traditional Chinese medicine production. The method comprises following steps: at first, taking different batches of salvianic acid A sodium eluent obtained during the macroporous resin elution process as samples to construct a correction sample set; measuring the salvianic acid A sodium contents of each sample of the correctionsample set by a standard method; then collecting and processing the primary near infrared spectral data of each sample to obtain the characteristic spectral data of each sample; based on the characteristic spectral data and salvianic acid A sodium contents of each sample, establishing a correction model by a stoichiometric method; and finally adopting the correction model to predict the salvianicacid A sodium content of salvianic acid A sodium eluent so as to determine the elution start point and terminal point during the elution process. The provided method has the advantages of rapidness,simpleness, accuracy, reliability, and good repeatability.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine production quality detection, in particular to a method and application for quickly judging the elution starting point and end point in the macroporous resin adsorption separation process of Danshensu sodium extract. Background technique [0002] Salvia miltiorrhiza is a traditional and precious traditional Chinese medicine. It is the dry root and rhizome of Salvia miltiorrhiza Bge., a plant in the Labiatae family. It tastes bitter and is slightly cold in nature. The effect of eliminating carbuncle. The water-soluble phenolic acids in Salvia miltiorrhiza mainly include danshensu, salvianolic acid B, etc. Modern pharmacological studies have shown that salvianolic acids have the functions of improving circulation, inhibiting platelet aggregation, anti-oxidation, increasing coronary flow and myocardial oxygen supply, and are the main active ingredients of salvia miltiorrhiza for...

Claims

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Application Information

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IPC IPC(8): G01N21/359
CPCG01N21/359
Inventor 罗江梅毕昌琼郁华军
Owner GUIZHOU JINGFENG INJECTION
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