Method for rapidly judging elution start point and terminal point during macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof

A technology of danshensu sodium and macroporous resin, which is applied in the field of quality inspection of traditional Chinese medicine production, can solve the problems of excessive eluent consumption and long elution time, and achieve low detection cost, fast and simple judgment process, and fast measurement speed Effect

Inactive Publication Date: 2018-10-23
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first object of the present invention is to provide a method for quickly judging the elution starting point and end point of the danshensu sodium extract in the macroporous resin adsorption separation process. The method is fast, simple, accurate, reliable, and reproducible, and can

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  • Method for rapidly judging elution start point and terminal point during macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof
  • Method for rapidly judging elution start point and terminal point during macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof
  • Method for rapidly judging elution start point and terminal point during macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof

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Example Embodiment

[0064] As a preferred embodiment of the present invention, the elution process of Danshensu sodium extract includes the following steps:

[0065] After the danshensu sodium extract was loaded and adsorbed by the macroporous resin, it was rinsed with purified water. From the beginning of the collection of the danshensu sodium effluent, samples were collected and separated from the danshensu sodium effluent every 1 to 10 minutes to obtain Different batches of Danshensu sodium effluent.

[0066] Since the Danshensu sodium extract is easily soluble in water, it can be eluted with purified water. The obtained Danshensu sodium effluent can also be called Danshensu sodium washing liquid. Among them, the typical but non-limiting time interval for sample collection is 1 min, 2 min, 3 min, 4 min, 5 min, 6 min, 7 min, 8 min, 9 min or 10 min.

[0067] As a preferred embodiment of the present invention, during the elution process of the danshensu sodium extract, the danshensu sodium extract is l...

Example Embodiment

[0084] Example 1

[0085] This embodiment provides a method for quickly determining the elution starting point and the end point of the danshensu sodium extract macroporous resin adsorption and separation process, including the following steps:

[0086] (1) Raw material processing: Take 300kg of Danshen medicinal material by physical method to obtain its decoction pieces;

[0087] (2) Process treatment: The Danshen decoction pieces are produced and prepared according to the actual production requirements. After the Danshensu sodium extract is loaded and adsorbed on the macroporous resin, it is washed with 6BV purified water at a flow rate of 6BV / h. Collect samples of the effluent of Danshensu sodium every 2 minutes, pass through a 0.45μm microporous membrane, and obtain different batches of danshensu sodium effluent for sealed storage;

[0088] (3) Establishment of the calibration model: select different batches of Danshensu sodium effluent obtained from the elution process of the Da...

Example Embodiment

[0114] Example 2

[0115] This embodiment provides a method for quickly determining the elution starting point and the end point of the danshensu sodium extract macroporous resin adsorption and separation process, including the following steps:

[0116] (1) Raw material processing: Take 300kg of Danshen medicinal material by physical method to obtain its decoction pieces;

[0117] (2) Process treatment: The Danshen decoction pieces are produced and prepared according to the actual production requirements. After the Danshensu sodium extract is loaded and adsorbed by the macroporous resin, it is washed with 12BV purified water at a flow rate of 12BV / h. Collect samples of the effluent of Danshensu sodium every 8 minutes, pass through a 0.45μm microporous membrane, and obtain different batches of Danshensu sodium effluent for sealed storage;

[0118] (3) Establishment of the calibration model: select different batches of Danshensu sodium effluent obtained from the elution process of the ...

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Abstract

The invention provides a method for rapidly judging the elution start point and terminal point during the macroporous resin absorption and separation process of salvianic acid A sodium and applications thereof, and relates to the technical field of quality detection in traditional Chinese medicine production. The method comprises following steps: at first, taking different batches of salvianic acid A sodium eluent obtained during the macroporous resin elution process as samples to construct a correction sample set; measuring the salvianic acid A sodium contents of each sample of the correctionsample set by a standard method; then collecting and processing the primary near infrared spectral data of each sample to obtain the characteristic spectral data of each sample; based on the characteristic spectral data and salvianic acid A sodium contents of each sample, establishing a correction model by a stoichiometric method; and finally adopting the correction model to predict the salvianicacid A sodium content of salvianic acid A sodium eluent so as to determine the elution start point and terminal point during the elution process. The provided method has the advantages of rapidness,simpleness, accuracy, reliability, and good repeatability.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine production quality detection, in particular to a method and application for quickly judging the elution starting point and end point in the macroporous resin adsorption separation process of Danshensu sodium extract. Background technique [0002] Salvia miltiorrhiza is a traditional and precious traditional Chinese medicine. It is the dry root and rhizome of Salvia miltiorrhiza Bge., a plant in the Labiatae family. It tastes bitter and is slightly cold in nature. The effect of eliminating carbuncle. The water-soluble phenolic acids in Salvia miltiorrhiza mainly include danshensu, salvianolic acid B, etc. Modern pharmacological studies have shown that salvianolic acids have the functions of improving circulation, inhibiting platelet aggregation, anti-oxidation, increasing coronary flow and myocardial oxygen supply, and are the main active ingredients of salvia miltiorrhiza for...

Claims

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Application Information

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IPC IPC(8): G01N21/359
CPCG01N21/359
Inventor 罗江梅毕昌琼郁华军
Owner GUIZHOU JINGFENG INJECTION
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