Blood biomarker for detecting arteriosclerosis

An arteriosclerosis and detection kit technology, applied in biological testing, biomaterial analysis, mammalian proteins, etc., can solve problems such as unclear arteriosclerotic lesions, improve independent living habits, improve life prognosis, and prevent the onset of diseases Effect

Pending Publication Date: 2018-10-23
PUBLIC UNIV CORP YOKOHAMA CITY UNIV +1
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Problems solved by technology

However, these marker proteins were identified using atherosclerotic model animals, and it is not yet clear whether they can evaluate atherosclerotic lesions in humans
In addition, this is a method of studying the protein expression level in the arterial tissue lesion site, and it is not necessarily possible to detect the presence of arteriosclerosis in a site other than the site to be examined, similar to carotid echocardiography

Method used

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  • Blood biomarker for detecting arteriosclerosis
  • Blood biomarker for detecting arteriosclerosis
  • Blood biomarker for detecting arteriosclerosis

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Embodiment

[0066] Next, the present invention will be described more specifically based on examples. However, the present invention is not limited to the following examples.

[0067] 1. Quantification of Myosin Heavy Chain 11 in Blood by Sandwich ELISA (Part 1)

[0068]

[0069] Subjects are patients who have arterial diseases such as stenosis, infarction, and aneurysm in coronary arteries, aorta, and peripheral vessels due to the progression of arteriosclerosis, and who have received catheter therapy or stent therapy. The presence of arteriosclerotic lesions in each patient was confirmed by angiography (confirmation of stenosis and infarction) or CT (confirmation of calcification). Patients with uncertain arteriosclerosis were excluded. Blood was collected from each patient before or immediately after intervention, plasma was separated from the blood, and the level of myosin heavy chain 11 (MYH11) in plasma was measured as the level of MYH11 in blood. 50 normal plasma samples (incl...

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Abstract

Disclosed is a novel means whereby it becomes possible to detect the pathology of arteriosclerosis in vivo by a less-invasive simple method. A method for detecting arteriosclerosis according to the present invention comprises measuring the level of myosin heavy-chain 11 in a blood sample isolated from a subject of interest. When the level of myosin heavy-chain 11 is higher than that in a normal person, the value of the level can be employed as a measure of the presence of arteriosclerosis in the subject. According to the present invention, arteriosclerosis can be detected by a blood test and the test can be carried out in a less-invasive and simple manner. The present invention can be expected to reflect the condition of blood vessels in the whole body, unlike techniques in which only a specific site is employed as a site to be tested, such as ultrasonographic assessment of a carotid artery.

Description

technical field [0001] The invention relates to a method for detecting arteriosclerosis by using the level of myosin heavy chain 11 in blood as an index. Background technique [0002] Due to the aging of the population and changes in lifestyle, diseases mainly involving arteriosclerosis such as coronary artery disease, peripheral artery disease, and aortic aneurysm are increasing. It is necessary to improve the prognosis by diagnosing arteriosclerotic diseases through non-invasive (invasive) or relatively simple examinations, and formulating appropriate examination and treatment plans. [0003] As a method of non-invasively detecting arteriosclerosis, there is a method of measuring the thickness of the intima-media complex, the presence of plaque, and the like from carotid artery echo. However, this method can only be diagnosed in a limited part of the carotid artery, and cannot necessarily detect arteriosclerosis in other parts. [0004] In the onset of arteriosclerosis, ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68C07K14/47G01N33/53
CPCG01N2800/323G01N33/6893G01N33/6887C07K14/4716G01N33/53C07K14/47G01N33/68
Inventor 横山诗子石川义弘荒川宪昭益田宗孝石上友章铃木伸一大竹则久小堀宏树
Owner PUBLIC UNIV CORP YOKOHAMA CITY UNIV
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