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Compound sulfamethoxazole tablet and preparation method thereof

A technology of methoxazole tablets and sulfamethoxazole, which is applied in the fields of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve the problem that the dissolution rate affects drug absorption, reduces the qualification rate of drugs, and loses value of drugs, etc. problems, to achieve the effect of improving bioequivalence, ensuring quality and curative effect, and ensuring stability

Inactive Publication Date: 2018-11-06
ZHENGZHOU MINGZE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the prepared compound sulfamethoxazole preparations generally have the problem of slow dissolution rate, and the slowdown of dissolution rate will greatly affect the absorption of the drug in the human body, making the drug lose its due value
In order to solve this problem in the preparation process in this field, most of them are to add a large amount of disintegrants. Although the addition of a large amount of disintegrants can obviously improve the dissolution rate of the preparation, the existence of a large amount of disintegrants will cause loose tablets , which seriously affects the quality of preparations, reduces the qualification rate of drugs, and affects the use of drugs

Method used

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  • Compound sulfamethoxazole tablet and preparation method thereof
  • Compound sulfamethoxazole tablet and preparation method thereof
  • Compound sulfamethoxazole tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A compound sulfamethoxazole tablet composition is prepared from the following ingredients in percentage by weight:

[0033]

[0034] The coating agent is an enteric film coating agent, and the coating agent accounts for 2% by mass of the total amount of the above-mentioned raw materials and auxiliary materials.

[0035] The preparation method of this compound sulfamethoxazole tablet composition is as follows:

[0036] (1) Prepare sulfamethoxazole, trimethoprim, starch (filler), starch (binder), low-substituted hydroxypropyl cellulose, sodium stearyl sulfonate, stearic acid according to the above prescription requirements Magnesium and enteric film coating agent, all passed through a 100-mesh sieve;

[0037] (2) Dissolve the starch (adhesive) prepared in step (1) in purified water and stir to obtain starch slurry (the mass concentration of the starch slurry obtained is 5%); then take the stearyl alcohol prepared in step (1) Sodium sulfonate is dissolved in purified ...

Embodiment 2

[0042] A compound sulfamethoxazole tablet composition is prepared from the following ingredients in percentage by weight:

[0043]

[0044] The coating agent is an enteric film coating agent, and the coating agent accounts for 3% by mass of the total amount of the above-mentioned raw materials and auxiliary materials.

[0045] The preparation method of this compound sulfamethoxazole tablet composition is as follows:

[0046] (1) Prepare sulfamethoxazole, trimethoprim, starch (filler), starch (binder), croscarmellose sodium, cetyltrimethylammonium bromide, Sodium stearyl fumarate, enteric film coating agent, all passed through a 100-mesh sieve;

[0047] (2) Dissolve the starch (adhesive) prepared in step (1) in purified water and stir evenly to obtain starch slurry (the mass concentration of the resulting starch slurry is 10%); then take the prepared decabromide in step (1) Hexaalkyltrimethylammonium is dissolved in purified water to obtain an aqueous solution of cetyltrimet...

Embodiment 3

[0051] A compound sulfamethoxazole tablet composition is prepared from the following ingredients in percentage by weight:

[0052]

[0053] The coating agent is an enteric film coating agent, and the coating agent accounts for 3% by mass of the total amount of the above-mentioned raw materials and auxiliary materials.

[0054] The preparation method of this compound sulfamethoxazole tablet composition is as follows:

[0055] (1) Prepare sulfamethoxazole, trimethoprim, starch (filler), starch (binder), croscarmellose sodium, cetyltrimethylammonium bromide, Sodium stearyl fumarate, enteric film coating agent, all passed through a 100-mesh sieve;

[0056] (2) Dissolve the starch (adhesive) prepared in step (1) in purified water and stir evenly to obtain starch slurry (the mass concentration of the resulting starch slurry is 8%); then take the prepared decabromide in step (1) Hexaalkyltrimethylammonium is dissolved in purified water, and after being completely dissolved, an a...

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Abstract

The invention discloses a compound sulfamethoxazole tablet and a preparation method of the compound sulfamethoxazole tablet. The compound sulfamethoxazole tablet takes sulfamethoxazole and trimethoprim as the main drugs, and is added with a filler, an adhesive, a disintegrating agent, a surfactant, a lubricant and a coating agent; and the compound sulfamethoxazole tablet is prepared through the steps of mixing, pelletizing, drying, tableting, coating and the like. The obtained compound sulfamethoxazole tablet composition effectively avoids the condition that the solid compound sulfamethoxazolepreparation is loosened because of weak granule viscosity, the dissolution of the preparation is obviously improved, the stability of the preparation is guaranteed, the product quality of the preparation is improved, the quality and the treatment effect of the preparation are guaranteed, and the compound sulfamethoxazole tablet has an excellent application prospect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound sulfamethoxazole tablet and a preparation method thereof. technical background [0002] Compound sulfamethoxazole preparation is a sulfonamide antibacterial drug, which is a compound preparation of sulfamethoxazole and trimethoprim. Enterobacteriaceae such as Lebsiella, Salmonella, Proteus, Morganella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, and Haemophilus influenzae all have good antibacterial effects, especially for large intestine The antibacterial effect of Escherichia, Haemophilus influenzae and Staphylococcus aureus was significantly stronger than that of sulfamethoxazole alone. In addition, the tablet has good antimicrobial activity against Chlamydia trachomatis, Nocardia star, protozoa, Toxoplasma gondii, etc. in vitro. [0003] The sulfamethoxazole in the compound sulfamethoxazole preparation acts on dihydrofolate synthase, interf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/20A61K47/18A61K31/635A61K31/505A61P31/04
CPCA61K9/2013A61K9/2059A61K9/2095A61K31/505A61K31/635A61P31/04A61K2300/00
Inventor 徐贡杰郭海波马兰兰谢芝丽李海剑
Owner ZHENGZHOU MINGZE MEDICAL TECH
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