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Immunomagnetic composition, preparation method and use thereof, and kit for treating cancer

A composition and magnetic technology, applied in immunoglobulins, organic active ingredients, chemical instruments and methods, etc., can solve the problems of inability to circulate into the target area, treatment is not very helpful, cancer cells are prone to mutation, etc. The effect of improving anti-cancer effect, convenience and stability, and excellent tumor suppressive ability

Active Publication Date: 2018-11-13
洪明奇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method is time-consuming and consumable, and the cancer cells in the patient's body are prone to mutation, which makes the reinfused immune cells lose their original effect
On the other hand, the microbeads used for proliferation can only be used for in vitro culture due to their large size, and cannot enter the target area through human blood circulation
In addition, in addition to the surface-grafted antibodies or coated active ingredients, the materials forming the carrier are usually excipients, which are not very helpful for the treatment itself, and will limit the dose when administered. Inherent flaws in similar materials

Method used

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  • Immunomagnetic composition, preparation method and use thereof, and kit for treating cancer
  • Immunomagnetic composition, preparation method and use thereof, and kit for treating cancer
  • Immunomagnetic composition, preparation method and use thereof, and kit for treating cancer

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Embodiment 2 test 。 pic 11B Embodiment 2 and IgG IO@FuDex test 。 pic 11CIO@FuDex no. 1、4、12 and 24 and 4T1 pic 。 pic 11D Embodiment 2 no. 1、4、12 and 24 and 4T1 pic 。 pic 11E1.4μg/ml(；L)、7μg/ml(；M) and 35 μg/ml(；H)CD3/CD28 Embodiment 3

[0098] Please refer to Figure 11A to Figure 11F , is an analysis result diagram of the targeting ability and cell binding ability of the immunomagnetic composition of the present invention. in Figure 11A In vitro targeting ability test of Example 2 of PD-L1 antibodies with grafting concentrations of 1.4 μg / ml (low concentration; L), 7 μg / ml (medium concentration; M) and 35 μg / ml (high concentration; H) result. Figure 11B It is the test result of Example 2 and IO@FuDex grafted with IgG in vitro targeting ability. Figure 11C It is the analysis results of IO@FuDex binding ability to 4T1 cell line at 1, 4, 12 and 24 hours. Figure 11D It is the analysis result diagram of the binding ability of Example 2 to 4T1 cell line at 1, 4, 12 and 24 hours. Figure 11E In vitro targeting ability of Example 3 of CD3 antibody / CD28 antibody with a grafting concentration of 1.4 μg / ml (low concentration; L), 7 μg / ml (medium concentration; M) and 35 μg / ml (high concentration; H) test resul...

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Abstract

An immunomagnetic composition, a preparation method and a use thereof, and a kit for treating a cancer are provided. The immunomagnetic composition comprises a core layer, a shell layer, and an outerlayer. The shell layer is composed of a composite and encapsulates the core layer. The composite is formed by the combination of fucoidan, oxidized dextran, and a plurality of superparamagnetic iron oxide nanoparticles by hydrophobic interaction. The outer layer comprises at least one antibody that is grated on the shell layer so as to form the outer layer. The immunomagnetic composition is applied to preparation of anti-cancer drugs.

Description

technical field [0001] The present invention relates to a composition and its preparation method, in particular to an immunomagnetic composition characterized by a special physical form, its preparation method, use and a kit for treating cancer. Background technique [0002] Cancer, also known as malignant tumor, is a state of abnormal proliferation of cells, and these hyperplastic cells may invade other parts of the body. It is a disease caused by an abnormal mechanism of controlling cell division and proliferation. The number of people suffering from cancer is increasing all over the world. Cancer is one of the top ten causes of death in China, and it has been the top ten cause of death for 27 consecutive years. [0003] Conventional cancer treatment methods include surgery, radiation therapy and chemotherapy. Immunotherapy is another method of treating cancer other than the above-mentioned treatment methods. It activates the patient's own immune system and uses tumor cel...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K31/715A61K41/00A61K45/06A61K47/36A61K47/02A61P35/00
CPCA61K39/395A61K39/3955A61K39/39566A61K41/00A61K45/06A61K47/02A61K47/36A61K31/715A61K2039/505A61K2039/507A61K2300/00A61K31/737A61P35/00A61K47/6923C07K16/00C07K16/2818C07K16/2809C07K16/2827A61K2039/804A61P35/04A61K2039/82A61K47/6929A61K47/6939A61K47/6849A61K47/6851
Inventor 徐伟成陈三元江智圣谢佳宏林佑融蔡长海
Owner 洪明奇
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